Facilitated brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound

Biomaterials ◽  
2014 ◽  
Vol 35 (10) ◽  
pp. 3384-3395 ◽  
Author(s):  
Lei Yao ◽  
Qingxiang Song ◽  
Wenkun Bai ◽  
Jizhen Zhang ◽  
Deyu Miao ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Brain Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Unfocused Ultrasound

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene

Biodegradable polymer blends of poly(lactic acid) and poly(ethylene glycol)

1997 ◽  
Vol 66 (8) ◽  
pp. 1495-1505 ◽  
Author(s):  
Mihir Sheth ◽  
R. Ananda Kumar ◽  
Vipul Dav� ◽  
Richard A. Gross ◽  
Stephen P. McCarthy
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Polymer Blends ◽  
Biodegradable Polymer ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Effect of Neonatal Exposure to Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Monika Dvořáková ◽  
Eva Rollerová ◽  
Soňa Scsuková ◽  
Alžbeta Bujňáková Mlynarčíková ◽  
Lucia Laubertová ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Female Rats ◽  
Protein Carbonyls ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Adult Rats ◽  
Potential Health ◽  
Age Related ◽  
Poly Ethylene

Our goal was to evaluate the potential health risk of the polymeric NP, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA), from the view of redox imbalance of the organism in two different life stages. Female Wistar rats were neonatally administered intraperitoneally with PEG-b-PLA NPs [20 mg/kg of b.w. (PEG20) or 40 (PEG40) mg/kg of b.w.] from postnatal day 4 (PND4) to PND7. We measured antioxidant capacity (TEAC), level of protein carbonyls and lipoperoxides in plasma, activities of catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD) in hemolysates of infantile (sacrificed on PND17) and adult (sacrificed after PND176) rats. Compared to controls, neonatal PEG40 exposure induced a significant TEAC reduction in the infantile rats. Protein carbonyls and lipoperoxide levels were not affected after any dose of PEG-b-PLA NP administration. In adult rats, PEG20 administration caused a significant decrease of protein carbonyl levels compared to controls. In infantile rats, both doses of PEG-b-PLA NP administration increased catalase, Gpx, and SOD activities compared to controls. Surprisingly, in adult rats, the activities of Gpx and SOD decreased significantly after administration of both doses of PEG-b-PLA NPs. Obtained data indicate a possible age-related association between the oxidative status and neonatal PEG-b-PLA NP administration in female rats.

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