Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

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Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

RSC Advances ◽

10.1039/c7ra02997g ◽

2017 ◽

Vol 7 (43) ◽

pp. 26640-26649 ◽

Cited By ~ 5

Author(s):

Tian Zhong ◽

Jia Fu ◽

Ran Huang ◽

Lianjiang Tan

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Core Shell ◽

Ph Responsive ◽

Photothermal Conversion ◽

Photothermal Ablation

Core–shell CuS(DOX)@CS nanospheres with pH-responsive drug release ability and photothermal conversion properties are synthesized for synergistic cancer therapy.

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Trackable Water-Soluble Prodrug Micelles Capable of Rapid Mitochondrial-Targeting and Alkaline pH-Responsive Drug Release for Highly Improved Anticancer Efficacy

ACS Macro Letters ◽

10.1021/acsmacrolett.9b00121 ◽

2019 ◽

Vol 8 (6) ◽

pp. 719-723 ◽

Cited By ~ 5

Author(s):

Bei-Yu Liu ◽

Xian-Ling Yang ◽

Xiu Xing ◽

Jun Li ◽

Yan-Hong Liu ◽

...

Keyword(s):

Drug Release ◽

Water Soluble ◽

Alkaline Ph ◽

Mitochondrial Targeting ◽

Ph Responsive ◽

Anticancer Efficacy

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Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

Journal of Materials Chemistry B ◽

10.1039/c5tb01830g ◽

2015 ◽

Vol 3 (46) ◽

pp. 9033-9042 ◽

Cited By ~ 47

Author(s):

Mengni He ◽

Jiajia Zhou ◽

Jian Chen ◽

Fangcai Zheng ◽

Dongdong Wang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Tumor Therapy ◽

Controlled Drug Release ◽

Ph Responsive ◽

Zeolitic Imidazolate Framework ◽

Drug Delivery Vehicles ◽

Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

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Block copolymer [(l-GluA-5-BE)-b-(l-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy

Journal of Materials Chemistry B ◽

10.1039/d0tb01647k ◽

2020 ◽

Vol 8 (40) ◽

pp. 9258-9268

Author(s):

Chander Amgoth ◽

Shuai Chen ◽

Tirupathi Malavath ◽

Guping Tang

Keyword(s):

Amino Acid ◽

Block Copolymer ◽

Cancer Therapy ◽

Drug Release ◽

Glutamic Acid ◽

Aspartic Acid ◽

Benzyl Ester ◽

Ph Responsive

Herein, the synthesis of an amino-acid-based di-block copolymer (di-BCP) in-between an l-glutamic acid-5-benzyl ester and L-aspartic acid-4-benzyl ester [(l-GluA-5-BE)-b-(l-AspA-4-BE)] has been reported.

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Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

Current Medicinal Chemistry ◽

10.2174/0929867324666170406110642 ◽

2018 ◽

Vol 25 (25) ◽

pp. 3036-3057 ◽

Cited By ~ 6

Author(s):

Xiao Sun ◽

Guilong Zhang ◽

Zhengyan Wu

Keyword(s):

Drug Delivery ◽

Magnetic Resonance ◽

Drug Release ◽

Contrast Enhancement ◽

General Strategy ◽

Ph Responsive ◽

Physicochemical Changes ◽

Magnetic Resonance Contrast ◽

Resonance Contrast ◽

Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200924110418 ◽

2020 ◽

Vol 20 ◽

Author(s):

Feng Wu ◽

Fei Qiu ◽

Siew Anthony Wai-Keong ◽

Yong Diao

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Targeted Delivery ◽

Relevant Information ◽

Therapeutic Effects ◽

Stimuli Responsive ◽

Control Effect ◽

Chemotherapy Drugs ◽

Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

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