scholarly journals A Src-H3 acetylation signaling axis integrates macrophage mechanosensation with inflammatory response

Biomaterials ◽  
2021 ◽  
pp. 121236
Author(s):  
Praveen Krishna Veerasubramanian ◽  
Hanjuan Shao ◽  
Vijaykumar S. Meli ◽  
Tri Andrew Q. Phan ◽  
Thuy U. Luu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Axis ◽  
H3 Acetylation

scholarly journals Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Cell Reports ◽  
2019 ◽  
Vol 29 (4) ◽  
pp. 860-872.e5 ◽  
Author(s):  
Ramon M. Rodriguez ◽  
Beatriz Suarez-Alvarez ◽  
Jose L. Lavín ◽  
Alex M. Ascensión ◽  
Monika Gonzalez ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Inflammatory Response ◽  
Signal Integration ◽  
Human Monocytes ◽  
Signaling Axis

Black raspberry anthocyanins protect BV2 microglia from LPS-induced inflammation through down-regulating NOX2/TXNIP/NLRP3 signaling

2021 ◽  
pp. 1-15
Author(s):  
Teng Mu ◽  
Yang Guan ◽  
Tianqiao Chen ◽  
Shuning Wang ◽  
Mei Li ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Receptor Protein ◽  
Black Raspberry ◽  
Interleukin 18 ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein ◽  
Immunological Mechanisms ◽  
Signaling Axis ◽  
Bv2 Microglia ◽  
Excessive Activation

BACKGROUND: Increasing evidence has established neuroinflammation as the hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD). However, despite the underlying immunological mechanisms are far from being understood, the involvement of excessive activation of microglia is attracting more and more attention. OBJECTIVE: In the present study, we investigated the protective effect of black raspberry (BRB) anthocyanins on LPS-induced neuroinflammation in BV2 microglia. METHODS: LPS-induced mouse BV2 microglia were treated with black raspberry anthocyanins and the levels of NO, ROS, IL-1β and IL-18 produced by the cells were measured to determine the extent of oxidative stress and inflammatory response. RESULTS: The results showed that BRB anthocyanins reduced the production of ROS in LPS-induced BV2 microglia by down-regulating the level of NOX2 and its downstream factors, including thioredoxin-interacting protein (TXNIP) and NOD-like receptor protein 3 (NLRP3) inflammasome. Furthermore, BRB anthocyanins inhibited the secretion of Interleukin-18 (IL-18) and Interleukin-1β (IL-1β), eventually attenuating the LPS-induced inflammatory response of BV2 microglia. CONCLUSIONS: BRB anthocyanins might play an important neuroprotective role in inflammation-related neurodegenerative disease, potentially, by down-regulating the NOX2 /TXNIP/ NLRP3 signaling axis in brain microglia.

scholarly journals The Roles of FOXO1 in Periodontal Homeostasis and Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Liang Ren ◽  
Jing Yang ◽  
Jun Wang ◽  
Xuedong Zhou ◽  
Chengcheng Liu
Keyword(s):  
Inflammatory Response ◽  
Periodontal Disease ◽  
Bone Remodeling ◽  
Chronic Inflammatory Disease ◽  
Periodontal Pathogens ◽  
Ros Scavenging ◽  
Cellular Processes ◽  
Periodontal Bacteria ◽  
Forkhead Box ◽  
Signaling Axis

Periodontitis is an oral chronic inflammatory disease that is initiated by periodontal microbial communities and requires disruption of the homeostatic responses. The prevalence of periodontal disease increases with age; more than 70% of adults 65 years and older have periodontal disease. A pathogenic microbial community is required for initiating periodontal disease. Dysbiotic immune-inflammatory response and bone remodeling are characteristics of periodontitis. The transcription factor forkhead box protein O1 (FOXO1) is a key regulator of a number of cellular processes, including cell survival and differentiation, immune status, reactive oxygen species (ROS) scavenging, and apoptosis. Although accumulating evidence indicates that FOXO1 activity can be induced by periodontal pathogens, the roles of FOXO1 in periodontal homeostasis and disease have not been well documented. The present review summarizes how the FOXO1 signaling axis can regulate periodontal bacteria-epithelial interactions, immune-inflammatory response, bone remodeling, and wound healing.

Gut permeabillity and nitric oxide: Evidence for an endotoxin mediated inflammatory response in severe acute pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Severe Acute Pancreatitis

ERK and PKCξ independently contribute to the EPEC-induced inflammatory response

2001 ◽  
Vol 120 (5) ◽  
pp. A126-A126
Author(s):  
S SAVKOVIC ◽  
Z KAPADIA ◽  
A KOUTSOURIS ◽  
G HECHT
Keyword(s):  
Inflammatory Response

Sorghum Fermented by Aspergillus oryzae NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells

2018 ◽  
Vol 88 (5-6) ◽  
pp. 309-318
Author(s):  
Hae Seong Song ◽  
Jung-Eun Kwon ◽  
Hyun Jin Baek ◽  
Chang Won Kim ◽  
Hyelin Jeon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Response ◽  
Smooth Muscle Cells ◽  
Adhesion Molecule ◽  
Vascular Inflammation ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Tnf Α ◽  
Cox 2

Abstract. Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study investigated the anti-vascular inflammation effects of sorghum extract (SBE) and fermented extract of sorghum (fSBE) on human aortic smooth muscle cells (HASMCs). After the cytotoxicity test of the sorghum extract, a series of experiments were conducted. The inhibition effects of SBE and fSBE on the inflammatory response and adhesion molecule expression were measured using treatment with tumor necrosis factor-α (TNF-α), a crucial promoter for the development of atherosclerotic lesions, on HASMCs. After TNF-α (10 ng/mL) treatment for 2 h, then SBE and fSBE (100 and 200 μg/mL) were applied for 12h. Western blotting analysis showed that the expression of vascular cell adhesion molecule-1 (VCAM-1) (2.4-fold) and cyclooxygenase-2 (COX-2) (6.7-fold) decreased, and heme oxygenase-1 (HO-1) (3.5-fold) increased compared to the TNF-α control when treated with 200 μg/mL fSBE (P<0.05). In addition, the fSBE significantly increased the expression of HO-1 and significantly decreased the expression of VCAM-1 and COX-2 compared to the TNF-α control in mRNA level (P<0.05). These reasons of results might be due to the increased concentrations of procyanidin B1 (about 6-fold) and C1 (about 30-fold) produced through fermentation with Aspergillus oryzae NK for 48 h, at 37 °C. Overall, the results demonstrated that fSBE enhanced the inhibition of the inflammatory response and adherent molecule expression in HASMCs.

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