scholarly journals Corrigendum to “Daphnegiravone D from Daphne giraldii induces cell death by targeting ATR in Hep3B cells” [Bioorg. Chem. 110 (2021) 104802]

2022 ◽  
Vol 119 ◽  
pp. 105584
Author(s):  
Xin-Yue Shang ◽  
Xiao-Qi Yu ◽  
Guo-Dong Yao ◽  
Shao-Jiang Song
Keyword(s):  
Cell Death ◽  
Hep3b Cells

Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells

2011 ◽  
Vol 726 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Ying Jiang ◽  
Xue Zhou ◽  
Xi Chen ◽  
Guangtao Yang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Mitochondrial Dysfunction ◽  
Hep3b Cells

STAT1 plays an essential role in LPS/D-galactosamine-induced liver apoptosis and injury

2003 ◽  
Vol 285 (4) ◽  
pp. G761-G768 ◽  
Author(s):  
Won-Ho Kim ◽  
Feng Hong ◽  
Svetlana Radaeva ◽  
Barbara Jaruga ◽  
Saijun Fan ◽  
...  
Keyword(s):  
Cell Death ◽  
Essential Role ◽  
Underlying Mechanism ◽  
Interferon Γ ◽  
Dominant Negative ◽  
Hepatitis C Infection ◽  
Hepatocellular Damage ◽  
Tnf Α ◽  
Hep3b Cells ◽  
Ifn Γ

Interferon-γ (IFN-γ) has been implicated in liver damage in animal models and chronic hepatitis C infection; however, the underlying mechanism is not clear. Here we examined the role of STAT1, a key signaling molecule for IFN-γ, in a model of murine hepatitis induced by the injection of LPS/d-galactosamine and in human hepatoma Hep3B cells. STAT1 is rapidly activated and highly induced after injection of LPS/d-galactosamine. Both overexpression of STAT1 and hepatocellular damage are located in the same pericentral region. Disruption of the STAT1 gene abolishes LPS/d-galactosamine-induced liver injury. Studies from IFN-γ-deficient mice indicate that IFN-γ is the major cytokine responsible for activation and hyperexpression of STAT1 in LPS/d-galactosamine-induced hepatitis. Hep3B cells overexpressing dominant negative STAT1 are resistant to IFN-γ and IFN-γ + TNF-α-induced cell death, whereas Hep3B cells overexpressing wild-type STAT1 are more susceptible to cell death. Taken together, these findings suggest that STAT1 plays an essential role in LPS/d-galactosamine-induced liver apoptosis and injury.

Daphnegiravone D from Daphne giraldii induces cell death by targeting ATR in Hep3B cells

2021 ◽  
pp. 104802
Author(s):  
Xin-Yue Shang ◽  
Xiao-Qi Yu ◽  
Guo-Dong Yao ◽  
Shao-Jiang Song
Keyword(s):  
Cell Death ◽  
Hep3b Cells

scholarly journals 16-Hydroxy-Lycopersene, a Polyisoprenoid Alcohol Isolated from Tournefortia hirsutissima, Inhibits Nitric Oxide Production in RAW 264.7 Cells and Induces Apoptosis in Hep3B Cells

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2366 ◽  
Author(s):  
Hurtado-Díaz ◽  
Sánchez-Carranza ◽  
Romero-Estrada ◽  
González-Maya ◽  
González-Christen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Hep3b Cells ◽  
Anti Inflammatory

Three polyisoprenoid alcohols were isolated from the leaves of Tournefortia hirsutissima by a bioassay-guided phytochemical investigation. The compounds were identified as 16-hydroxy-lycopersene (Compound 1), (Z8,E3,ω)-dodecaprenol (Compound 2) and (Z9,E3,ω)-tridecaprenol (Compound 3). Compound 1, an unusual polyisoprenoid, was characterized by 1D and 2D NMR. We also determined the absolute configuration at C-16 by the modified Mosher’s method. The in vitro antiproliferative and anti-inflammatory activities of the isolated compounds were evaluated. Among isolates, Compound 1 moderately inhibited the nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. On the other hand, Compound 1 displayed selective antiproliferative activity against HeLa, PC3, HepG2 and Hep3B cancer cells and was less potent against IHH non-cancerous cells. Compound 1 in Hep3B cells showed significant inhibition of cell cycle progression increasing the sub-G1 phase, suggesting cell death. Acridine orange/ethidium bromide staining and Annexin V-FITC/PI staining demonstrated that cell death induced by Compound 1 in cells Hep3B was by apoptosis. Further study showed that apoptosis induced by Compound 1 in Hep3b cells is associated with the increase of the ratio of Bax/Bcl-2, and caspase 3/7 activation. These results suggest that Compound 1 induce apoptotic cell death by the mitochondrial pathway. To our knowledge, this is the first report about the presence of polyprenol Compounds 1–3 in T. hirsutissima, and the apoptotic and anti-inflammatory action of Compound 1.

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