scholarly journals Research progress in use of traditional Chinese medicine for treatment of spinal cord injury

2020 ◽  
Vol 127 ◽  
pp. 110136 ◽  
Author(s):  
Yubao Lu ◽  
Jingjing Yang ◽  
Xuexi Wang ◽  
Zhanjun Ma ◽  
Sheng Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Research Progress ◽  
Cord Injury

scholarly journals Therapeutic Effects of Traditional Chinese Medicine on Spinal Cord Injury: A Promising Supplementary Treatment in Future

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Qian Zhang ◽  
Hao Yang ◽  
Jing An ◽  
Rui Zhang ◽  
Bo Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Epigallocatechin Gallate ◽  
Therapeutic Effects ◽  
Cord Injury ◽  
Supplementary Treatment ◽  
Natural Drugs ◽  
Doctoral Dissertations

Objective. Spinal cord injury (SCI) is a devastating neurological disorder caused by trauma. Pathophysiological events occurring after SCI include acute, subacute, and chronic phases, while complex mechanisms are comprised. As an abundant source of natural drugs, Traditional Chinese Medicine (TCM) attracts much attention in SCI treatment recently. Hence, this review provides an overview of pathophysiology of SCI and TCM application in its therapy.Methods. Information was collected from articles published in peer-reviewed journals via electronic search (PubMed, SciFinder, Google Scholar, Web of Science, and CNKI), as well as from master’s dissertations, doctoral dissertations, and Chinese Pharmacopoeia.Results. Both active ingredients and herbs could exert prevention and treatment against SCI, which is linked to antioxidant, anti-inflammatory, neuroprotective, or antiapoptosis effects. The detailed information of six active natural ingredients (i.e., curcumin, resveratrol, epigallocatechin gallate, ligustrazine, quercitrin, and puerarin) and five commonly used herbs (i.e., Danshen, Ginkgo, Ginseng, Notoginseng, and Astragali Radix) was elucidated and summarized.Conclusions. As an important supplementary treatment, TCM may provide benefits in repair of injured spinal cord. With a general consensus that future clinical approaches will be diversified and a combination of multiple strategies, TCM is likely to attract greater attention in SCI treatment.

Simultaneous determination of 41 components in Gualou Guizhi granules by UPLC coupled with triple quadrupole mass spectrometry

2015 ◽  
Vol 7 (19) ◽  
pp. 8285-8296 ◽  
Author(s):  
Yu Lin ◽  
Wei Xu ◽  
Wen Xu ◽  
Mingqing Huang ◽  
Yuqin Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Triple Quadrupole ◽  
Quadrupole Mass ◽  
Classical Formula ◽  
Cord Injury

Gualou Guizhi granules (GLGZGs) are a classical formula of traditional Chinese medicine, which have been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury.

scholarly journals The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yixin Chen ◽  
Suixin Liu ◽  
Jianjun Li ◽  
Zhe Li ◽  
Jing Quan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glutathione Peroxidase ◽  
Mevalonate Pathway ◽  
Morphological Changes ◽  
Ischemia Reperfusion ◽  
Research Progress ◽  
Transsulfuration Pathway ◽  
Cord Injury ◽  
Generative Mechanism

Ferroptosis is a recently identified nonapoptotic form of cell death whose major markers are iron dependence and accumulation of lipid reactive oxygen species, accompanied by morphological changes such as shrunken mitochondria and increased membrane density. It appears to contribute to the death of tumors, ischemia-reperfusion, acute renal failure, and nervous system diseases, among others. The generative mechanism of ferroptosis includes iron overloading, lipid peroxidation, and downstream execution, while the regulatory mechanism involves the glutathione/glutathione peroxidase 4 pathway, as well as the mevalonate pathway and the transsulfuration pathway. In-depth research has continuously developed and enriched knowledge on the mechanism by which ferroptosis occurs. In recent years, reports of the noninterchangeable role played by selenium in glutathione peroxidase 4 and its function in suppressing ferroptosis and the discovery of ferroptosis suppressor protein 1, identified as a ferroptosis resistance factor parallel to the glutathione peroxidase 4 pathway, have expanded and deepened our understanding of the mechanism by which ferroptosis works. Ferroptosis has been reported in spinal cord injury animal model experiments, and the inhibition of ferroptosis could promote the recovery of neurological function. Here, we review the latest studies on mechanism by which ferroptosis occurs, focusing on the ferroptosis execution and the contents related to selenium and ferroptosis suppressor protein 1. In addition, we summarize the current research status of ferroptosis in spinal cord injury. The aim of this review is to better understand the mechanisms by which ferroptosis occurs and its role in the pathophysiological process of spinal cord injury, so as to provide a new idea and frame of reference for further exploration.

Research progress and prospects of tissue engineering scaffolds for spinal cord injury repair and protection

2019 ◽  
Vol 14 (9) ◽  
pp. 887-898
Author(s):  
Zhanjun Ma ◽  
Yubao Lu ◽  
Yang Yang ◽  
Jing Wang ◽  
Xuewen Kang
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Spinal Cord Injury ◽  
Research Progress ◽  
Comprehensive Treatment ◽  
Biological Factors ◽  
Tissue Engineering Scaffolds ◽  
Biological Scaffolds ◽  
Injury Repair ◽  
Cord Injury

Spinal cord injury (SCI) is one of the leading causes of global disability. However, there are currently no effective clinical treatments for SCI. Repair of SCI is essential but poses great challenges. As a comprehensive treatment program combining biological scaffolds, seed cells and drugs or biological factors, tissue engineering has gradually replaced the single transplantation approach to become a focus of research that brings new opportunities for the clinical treatment of SCI.

scholarly journals Progress in Stem Cell Therapy for Spinal Cord Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Liansheng Gao ◽  
Yucong Peng ◽  
Weilin Xu ◽  
Pingyou He ◽  
Tao Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Research Progress ◽  
High Morbidity ◽  
Hematopoietic Stem ◽  
3D Print ◽  
New Approaches ◽  
Cord Injury

Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur in young people with high morbidity and disability. However, there is still a lack of effective treatments for it. Stem cell (SC) treatment of SCI has gradually become a new research hotspot over the past decades. This article is aimed at reviewing the research progress of SC therapy for SCI. Methods. Review the literature and summarize the effects, strategies, related mechanisms, safety, and clinical application of different SC types and new approaches in combination with SC in SCI treatment. Results. A large number of studies have focused on SC therapy for SCI, most of which showed good effects. The common SC types for SCI treatment include mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), neural stem cells (NSCs), induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs). The modes of treatment include in vivo and in vitro induction. The pathways of transplantation consist of intravenous, transarterial, nasal, intraperitoneal, intrathecal, and intramedullary injections. Most of the SC treatments for SCI use a number of cells ranging from tens of thousands to millions. Early or late SC administration, application of immunosuppressant or not are still controversies. Potential mechanisms of SC therapy include tissue repair and replacement, neurotrophy, and regeneration and promotion of angiogenesis, antiapoptosis, and anti-inflammatory. Common safety issues include thrombosis and embolism, tumorigenicity and instability, infection, high fever, and even death. Recently, some new approaches, such as the pharmacological activation of endogenous SCs, biomaterials, 3D print, and optogenetics, have been also developed, which greatly improved the application of SC therapy for SCI. Conclusion. Most studies support the effects of SC therapy on SCI, while a few studies do not. The cell types, mechanisms, and strategies of SC therapy for SCI are very different among studies. In addition, the safety cannot be ignored, and more clinical trials are required. The application of new technology will promote SC therapy of SCI.

Sign in / Sign up

Export Citation Format

Share Document