Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis

Obesity is becoming one of the greatest threats to global health in the 21st century and therefore the development of novel antiobesity drugs is one of the top priorities of global drug research. An important treatment strategy includes the reduction of intestinal fat absorption through the inhibition of pancreatic lipase (PL). Natural products provide a vast pool of PL inhibitors with novel scaffolds that can possibly be developed into clinical products. Computational drug design methods have become increasingly invaluable in the drug discovery process. In recent years, the discovery of new antiobesity PL inhibitors has been facilitated by the application of computational methods. This review highlights some computer-aided drug design techniques utilized in the discovery of natural PL inhibitors.

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Cannabinoid Receptor Antagonists as Potential Antiobesity Agents

Handbook of Obesity ◽

10.3109/9781420051452-21 ◽

2008 ◽

pp. 335-340

Keyword(s):

Cannabinoid Receptor ◽

Receptor Antagonists ◽

Antiobesity Agents

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Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents

Natural Products and Bioprospecting ◽

10.1007/s13659-015-0062-6 ◽

2015 ◽

Vol 5 (3) ◽

pp. 129-157 ◽

Cited By ~ 14

Author(s):

Kun Wei ◽

Gang-Qiang Wang ◽

Xue Bai ◽

Yan-Fen Niu ◽

He-Ping Chen ◽

...

Keyword(s):

Pancreatic Lipase ◽

Biological Evaluation ◽

Antiobesity Agents ◽

Pancreatic Lipase Inhibitors

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Effects of GLP-1 and Incretin-Based Therapies on Gastrointestinal Motor Function

Experimental Diabetes Research ◽

10.1155/2011/279530 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10 ◽

Cited By ~ 43

Author(s):

Chinmay S. Marathe ◽

Christopher K. Rayner ◽

Karen L. Jones ◽

Michael Horowitz

Keyword(s):

Inhibitory Action ◽

Current Knowledge ◽

Incretin Hormone ◽

Distal Small Intestine ◽

Gastrointestinal Motor ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Antiobesity Agents ◽

Motor Actions

Glucagon-like peptide 1 (GLP-1) is a hormone secreted predominantly by the distal small intestine and colon and released in response to enteral nutrient exposure. GLP-1-based therapies are now used widely in the management of type 2 diabetes and have the potential to be effective antiobesity agents. Although widely known as an incretin hormone, there is a growing body of evidence that GLP-1 also acts as an enterogastrone, with profound effects on the gastrointestinal motor system. Moreover, the effects of GLP-1 on gastrointestinal motility appear to be pivotal to its effect of reducing postprandial glycaemic excursions and may, potentially, represent the dominant mechanism. This review summarizes current knowledge of the enterogastrone properties of GLP-1, focusing on its effects on gut motility at physiological and pharmacological concentrations, and the motor actions of incretin-based therapies. While of potential importance, the inhibitory action of GLP-1 on gastric acid secretion is beyond the scope of this paper.

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Plants' Metabolites as Potential Antiobesity Agents

The Scientific World JOURNAL ◽

10.1100/2012/436039 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 22

Author(s):

Najla Gooda Sahib ◽

Nazamid Saari ◽

Amin Ismail ◽

Alfi Khatib ◽

Fawzi Mahomoodally ◽

...

Keyword(s):

Medicinal Plants ◽

New Technology ◽

New Drugs ◽

Natural Health Products ◽

Metabolizing Enzymes ◽

Obesity Research ◽

Health Products ◽

To Come ◽

Antiobesity Agents

Obesity and obesity-related complications are on the increase both in the developed and developing world. Since existing pharmaceuticals fail to come up with long-term solutions to address this issue, there is an ever-pressing need to find and develop new drugs and alternatives. Natural products, particularly medicinal plants, are believed to harbor potential antiobesity agents that can act through various mechanisms either by preventing weight gain or promoting weight loss amongst others. The inhibition of key lipid and carbohydrate hydrolyzing and metabolizing enzymes, disruption of adipogenesis, and modulation of its factors or appetite suppression are some of the plethora of targeted approaches to probe the antiobesity potential of medicinal plants. A new technology such as metabolomics, which deals with the study of the whole metabolome, has been identified to be a promising technique to probe the progression of diseases, elucidate their pathologies, and assess the effects of natural health products on certain pathological conditions. This has been applied to drug research, bone health, and to a limited extent to obesity research. This paper thus endeavors to give an overview of those plants, which have been reported to have antiobesity effects and highlight the potential and relevance of metabolomics in obesity research.

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Effect ofHibiscus sabdariffaL. Dried Calyx Ethanol Extract on Fat Absorption-Excretion, and Body Weight Implication in Rats

Journal of Biomedicine and Biotechnology ◽

10.1155/2009/394592 ◽

2009 ◽

Vol 2009 ◽

pp. 1-5 ◽

Cited By ~ 14

Author(s):

O. Carvajal-Zarrabal ◽

P. M. Hayward-Jones ◽

Z. Orta-Flores ◽

C. Nolasco-Hipólito ◽

D. M. Barradas-Dermitz ◽

...

Keyword(s):

Body Weight ◽

Food Consumption ◽

Control Diet ◽

Body Weight Loss ◽

Ethanol Extract ◽

Basal Diet ◽

Hibiscus Sabdariffa ◽

Fat Absorption ◽

Collateral Effect ◽

Antiobesity Agents

The effect ofHibiscus sabdariffaL. (Hs) calyx extract on fat absorption-excretion and body weight in rats, was investigated. Rats were fed with either a basal diet (SDC = Control diet) or the same diet supplemented with Hs extracts at 5%, 10% and 15% ( , and ). Only did not show significant increases in weight, food consumption and efficiency compared to . The opposite occurred in group which showed a significant decrease for these three parameters. The responses were similar to , with the exception of food consumption. In both and groups, no body weight loss was observed; however, only in the latter group was there a significantly greater amount of fatty acids found in feces. A collateral effect emerging from the study is that components of Hs extract at the intermediate and greater concentrations used in this experiment could be considered possible antiobesity agents.

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