Mother’s Little Helpers: The Effects of Diazepam and Chronic Fluoxetine on Anxiety Differs in Nulliparous and Primiparous Rats

2021 ◽  
Vol 89 (9) ◽  
pp. S293
Author(s):  
Jodie Pestana ◽  
Bronwyn Graham
Keyword(s):  
Chronic Fluoxetine

scholarly journals Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Science ◽  
2013 ◽  
Vol 340 (6137) ◽  
pp. 1234-1239 ◽  
Author(s):  
Susanne E. Ahmari ◽  
Timothy Spellman ◽  
Neria L. Douglass ◽  
Mazen A. Kheirbek ◽  
H. Blair Simpson ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Orbitofrontal Cortex ◽  
Progressive Increase ◽  
Repetitive Behaviors ◽  
Mouse Behavior ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Chronic Fluoxetine

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.

Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats

2007 ◽  
Vol 0 (0) ◽  
pp. 070905010742003-??? ◽  
Author(s):  
A. B. Marcussen ◽  
P. Flagstad ◽  
P. E. G. Kristjansen ◽  
F. F. Johansen ◽  
U. Englund
Keyword(s):  
Wistar Rats ◽  
Fluoxetine Treatment ◽  
Chronic Fluoxetine

Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.

2020 ◽  
Author(s):  
Brunella V. González Cautela ◽  
Gonzalo R. Quintana ◽  
Jessica Akerman ◽  
James G. Pfaus
Keyword(s):  
Sexual Behavior ◽  
Male Rats ◽  
Chronic Fluoxetine
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