Lactic acid production by Lactobacillus sp. RKY2 in a cell-recycle continuous fermentation using lignocellulosic hydrolyzates as inexpensive raw materials

2009 ◽  
Vol 100 (18) ◽  
pp. 4262-4270 ◽  
Author(s):  
Young-Jung Wee ◽  
Hwa-Won Ryu
1983 ◽  
Vol 5 (10) ◽  
pp. 665-670 ◽  
Author(s):  
T. B. Vick Roy ◽  
D. K. Mandel ◽  
D. K. Dea ◽  
H. W. Blanch ◽  
C. R. Wilke

Processes ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 199 ◽  
Author(s):  
Ashish Manandhar ◽  
Ajay Shah

Lactic acid is an important chemical with numerous commercial applications that can be fermentatively produced from biological feedstocks. Producing lactic acid from corn grain could complement the use of already existing infrastructure for corn grain-based ethanol production with a higher value product. The objective of this study was to evaluate the techno-economic feasibility of producing 100,000 metric tons (t) of lactic acid annually from corn grain in a biorefinery. The study estimated the resources (equipment, raw materials, energy, and labor) requirements and costs to produce lactic acid from bacteria, fungi and yeast-based fermentation pathways. Lactic acid production costs were $1181, $1251 and $844, for bacteria, fungi and yeast, respectively. Genetically engineered yeast strains capable of producing lactic acid at low pH support significantly cheaper processes because they do not require simultaneous neutralization and recovery of lactic acid, resulting in lower requirements for chemical, equipment, and utilities. Lactic acid production costs were highly sensitive to sugar-to-lactic-acid conversion rates, grain price, plant size, annual operation hours, and potential use of gypsum. Improvements in process efficiencies and lower equipment and chemical costs would further reduce the cost of lactic acid production from corn grain.


RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17659-17668 ◽  
Author(s):  
Mohamed Ali Abdel-Rahman ◽  
Yukihiro Tashiro ◽  
Takeshi Zendo ◽  
Kenji Sakai ◽  
Kenji Sonomoto

We report an effective cell recycling continuous fermentation of xylose to l-lactic acid with high concentration, productivity, and yield using strain QU 25. pH was found to affect the yield and corn steep liquor as feeding medium enhanced the yield.


2005 ◽  
Vol 96 (13) ◽  
pp. 1492-1498 ◽  
Author(s):  
Hurok Oh ◽  
Young-Jung Wee ◽  
Jong-Sun Yun ◽  
Seung Ho Han ◽  
Sangwon Jung ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2474 ◽  
Author(s):  
Peirong Cai ◽  
Nannan Feng ◽  
Wanglong Zheng ◽  
Hao Zheng ◽  
Hui Zou ◽  
...  

Zearalenone (ZEA) interferes with the function of the male reproductive system, but its molecular mechanism has yet to be completely elucidated. Sertoli cells (SCs) are important in the male reproductive system. Silencing information regulator 1 (SIRT1) is a cell metabolism sensor and resveratrol (RSV) is an activator of SIRT1. In this study we investigated whether SIRT1 is involved in the regulation of ZEA-induced lactate metabolism disorder in SCs. The results showed that the cytotoxicity of ZEA toward SCs increased with increasing ZEA concentration. Moreover, ZEA induced a decrease in the production of lactic acid and pyruvate of SCs and inhibited the expression of glycolytic genes and lactic acid production-related proteins. ZEA also led to a decreased expression of SIRT1 in energy receptors and decreased ATP levels in SCs. However, the ZEA-induced cytotoxicity and decline in lactic acid production in SCs were alleviated by the use of RSV, which is an activator of SIRT1. In summary, ZEA decreased lactic acid production in SCs, while the treatment with an SIRT1 activator, RSV, restored the inhibition of lactic acid production in SCs and reduced cytotoxicity of ZEA toward SCs.


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