Microbial synthesis of poly-3-hydroxybutyrate and its application as targeted drug delivery vehicle

Here we construct the first pillararene-based amphiphilic supramolecular brush copolymer, which can be utilized as a targeting self-imaging drug delivery vehicle.

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Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2006.07.046 ◽

2007 ◽

Vol 328 (1) ◽

pp. 86-94 ◽

Cited By ~ 71

Author(s):

Mina Nikanjam ◽

Eleanor A. Blakely ◽

Kathleen A. Bjornstad ◽

Xiao Shu ◽

Thomas F. Budinger ◽

...

Keyword(s):

Drug Delivery ◽

Glioblastoma Multiforme ◽

Targeted Drug Delivery ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Delivery Vehicle ◽

Drug Delivery Vehicle ◽

Targeted Drug

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Biomimetic matrix mediated room temperature synthesis and characterization of nano-hydroxyapatite towards targeted drug delivery

RSC Advances ◽

10.1039/c6ra06759j ◽

2016 ◽

Vol 6 (67) ◽

pp. 62556-62571 ◽

Cited By ~ 14

Author(s):

Lubna Sheikh ◽

Sucheta Tripathy ◽

Suprabha Nayar

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Room Temperature ◽

Nucleation And Growth ◽

Hydroxyapatite Nanoparticles ◽

Delivery Vehicle ◽

Temperature Synthesis ◽

Targeted Drug ◽

Potent Drug

Nucleation and growth of hydroxyapatite nanoparticles in the presence of different matrices acting as a potent drug delivery vehicle.

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Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

Nanoscale ◽

10.1039/c5nr06122a ◽

2016 ◽

Vol 8 (2) ◽

pp. 938-948 ◽

Cited By ~ 56

Author(s):

Simon Heidegger ◽

Dorothée Gößl ◽

Alexandra Schmidt ◽

Stefan Niedermayer ◽

Christian Argyo ◽

...

Keyword(s):

Drug Delivery ◽

Immune Response ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Immune Cells ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Delivery Vehicle ◽

Functionalized Mesoporous Silica ◽

Targeted Drug

Mesoporous silica nanoparticles represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic.

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Liposomal Tumor Targeting in Drug Delivery Utilizing MMP-2- and MMP-9-Binding Ligands

Journal of Drug Delivery ◽

10.1155/2011/160515 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

Oula Penate Medina ◽

Merja Haikola ◽

Marja Tahtinen ◽

Ilkka Simpura ◽

Sami Kaukinen ◽

...

Keyword(s):

Drug Delivery ◽

Phage Display ◽

Targeted Drug Delivery ◽

Tumor Targeting ◽

Treatment Options ◽

Delivery Vehicle ◽

High Affinity ◽

Binding Peptides ◽

Delivery Strategies ◽

Targeted Drug

Nanotechnology offers an alternative to conventional treatment options by enabling different drug delivery and controlled-release delivery strategies. Liposomes being especially biodegradable and in most cases essentially nontoxic offer a versatile platform for several different delivery approaches that can potentially enhance the delivery and targeting of therapies to tumors. Liposomes penetrate tumors spontaneously as a result of fenestrated blood vessels within tumors, leading to known enhanced permeability and subsequent drug retention effects. In addition, liposomes can be used to carry radioactive moieties, such as radiotracers, which can be bound at multiple locations within liposomes, making them attractive carriers for molecular imaging applications. Phage display is a technique that can deliver various high-affinity and selectivity peptides to different targets. In this study, gelatinase-binding peptides, found by phage display, were attached to liposomes by covalent peptide-PEG-PE anchor creating a targeted drug delivery vehicle. Gelatinases as extracellular targets for tumor targeting offer a viable alternative for tumor targeting. Our findings show that targeted drug delivery is more efficient than non-targeted drug delivery.

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