Exosomes separated based on the “STOP” criteria for tumor-targeted drug delivery

Here we construct the first pillararene-based amphiphilic supramolecular brush copolymer, which can be utilized as a targeting self-imaging drug delivery vehicle.

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Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2006.07.046 ◽

2007 ◽

Vol 328 (1) ◽

pp. 86-94 ◽

Cited By ~ 71

Author(s):

Mina Nikanjam ◽

Eleanor A. Blakely ◽

Kathleen A. Bjornstad ◽

Xiao Shu ◽

Thomas F. Budinger ◽

...

Keyword(s):

Drug Delivery ◽

Glioblastoma Multiforme ◽

Targeted Drug Delivery ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Delivery Vehicle ◽

Drug Delivery Vehicle ◽

Targeted Drug

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Biomimetic matrix mediated room temperature synthesis and characterization of nano-hydroxyapatite towards targeted drug delivery

RSC Advances ◽

10.1039/c6ra06759j ◽

2016 ◽

Vol 6 (67) ◽

pp. 62556-62571 ◽

Cited By ~ 14

Author(s):

Lubna Sheikh ◽

Sucheta Tripathy ◽

Suprabha Nayar

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Room Temperature ◽

Nucleation And Growth ◽

Hydroxyapatite Nanoparticles ◽

Delivery Vehicle ◽

Temperature Synthesis ◽

Targeted Drug ◽

Potent Drug

Nucleation and growth of hydroxyapatite nanoparticles in the presence of different matrices acting as a potent drug delivery vehicle.

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Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

Nanoscale ◽

10.1039/c5nr06122a ◽

2016 ◽

Vol 8 (2) ◽

pp. 938-948 ◽

Cited By ~ 56

Author(s):

Simon Heidegger ◽

Dorothée Gößl ◽

Alexandra Schmidt ◽

Stefan Niedermayer ◽

Christian Argyo ◽

...

Keyword(s):

Drug Delivery ◽

Immune Response ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Immune Cells ◽

Targeted Drug Delivery ◽

Mesoporous Silica Nanoparticles ◽

Delivery Vehicle ◽

Functionalized Mesoporous Silica ◽

Targeted Drug

Mesoporous silica nanoparticles represent an efficient drug delivery vehicle to primary immune cells that is both non-toxic and non-inflammagenic.

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Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

10.1101/315044 ◽

2018 ◽

Author(s):

Q Zhong ◽

BC Yoon ◽

M Aryal ◽

JB Wang ◽

A Karthik ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Focused Ultrasound ◽

Drug Loading ◽

The Body ◽

Clinical Translation ◽

Drug Infusion ◽

Targeted Drug ◽

Perfluorocarbon Nanoemulsions

ABSTRACTCatheter-based intra-arterial drug therapies have proven effective for a range of oncologic, neurologic, and cardiovascular applications. However, these procedures are limited by their invasiveness, as well as the relatively broad drug spatial distribution that is achievable with selective arterial catheterization. The ideal technique for local pharmacotherapy would be noninvasive and would flexibly deliver a given drug to any region of the body. Combining polymeric perfluorocarbon nanoemulsions with existent clinical focused ultrasound systems could in principle enable noninvasive targeted drug delivery, but it has not been clear whether these nanoparticles could provide the necessary drug loading, stability, and generalizability across a range of drugs to meet these needs, beyond a few niche applications. Here, we directly address all of those challenges and fully develop polymeric perfluorocarbon nanoemulsions into a generalized platform for ultrasound-targeted drug delivery with high potential for clinical translation. We demonstrate that a wide variety of drugs may be effectively uncaged with ultrasound using these nanoparticles, with drug loading increasing with hydrophobicity. We also set the stage for clinical translation by delineating production protocols that hew to clinical standards and yield stable and optimized ultrasound-activated drug-loaded nanoemulsions. Finally, as a new potential clinical application for these nanoemulsions, we exhibit their in vivo efficacy and performance for cardiovascular applications, by achieving local vasodilation in the highest flow vessel of the body, the aorta. This work establishes the power of polymeric perfluorocarbon nanoemulsions as a clinically-translatable platform for effective noninvasive ultrasonic drug uncaging for myriad targets in the brain and body.

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