New strategy for the gene mutation identification using surface enhanced Raman spectroscopy (SERS)

2019 ◽  
Vol 132 ◽  
pp. 326-332 ◽  
Author(s):  
Agata Kowalczyk ◽  
Jan Krajczewski ◽  
Artur Kowalik ◽  
Jan L. Weyher ◽  
Igor Dzięcielewski ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Gene Mutation ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
New Strategy ◽  
Surface Enhanced Raman ◽  
Mutation Identification

Ultrathin layer solid transformation-enabled-surface enhanced Raman spectroscopy for trace harmful small gaseous molecule detection

2020 ◽  
Vol 5 (4) ◽  
pp. 739-746 ◽  
Author(s):  
Haoming Bao ◽  
Hongwen Zhang ◽  
Hao Fu ◽  
Le Zhou ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Gaseous Molecule ◽  
Surface Enhanced ◽  
New Strategy ◽  
Surface Enhanced Raman ◽  
Ultrathin Layer

A new strategy – ultrathin layer solid transformation-enabled-SERS – is presented for rapid and ultrasensitive detection of harmful small gaseous molecules.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

Sign in / Sign up

Export Citation Format

Share Document