High plasma dipeptidyl peptidase 3 levels are associated with mortality and organ failure in shock: results from the international, prospective and observational FROG-ICU cohort

2021 ◽  
Author(s):  
Benjamin Deniau ◽  
Adrien Picod ◽  
Dirk Van Lier ◽  
Prabakar Vaittinada Ayar ◽  
Karine Santos ◽  
...  
Keyword(s):  
Organ Failure ◽  
Dipeptidyl Peptidase ◽  
High Plasma ◽  
Dipeptidyl Peptidase 3

scholarly journals Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Alice Blet ◽  
◽  
Benjamin Deniau ◽  
Karine Santos ◽  
Dirk P. T. van Lier ◽  
...  
Keyword(s):  
Organ Failure ◽  
Sofa Score ◽  
Dipeptidyl Peptidase ◽  
Organ Support ◽  
Multinational Study ◽  
Organ Function ◽  
Term Outcome ◽  
Failure Assessment ◽  
Fluid Load ◽  
Dipeptidyl Peptidase 3

Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunction and mortality in cardiogenic shock patients. Methods The aim was to assess relationships between cDPP3 during the initial intensive care unit (ICU) stay and short-term outcome in the AdrenOSS-1, a prospective observational multinational study in twenty-four ICU centers in five countries. AdrenOSS-1 included 585 patients admitted to the ICU with severe sepsis or septic shock. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by the Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use and need for renal replacement therapy. cDPP3 levels were measured upon admission and 24 h later. Results Median [IQR] cDPP3 concentration upon admission was 26.5 [16.2–40.4] ng/mL. Initial SOFA score was 7 [5–10], and 28-day mortality was 22%. We found marked associations between cDPP3 upon ICU admission and 28-day mortality (unadjusted standardized HR 1.8 [CI 1.6–2.1]; adjusted HR 1.5 [CI 1.3–1.8]) and between cDPP3 levels and change in renal and liver SOFA score (p = 0.0077 and 0.0009, respectively). The higher the initial cDPP3 was, the greater the need for organ support and vasopressors upon admission; the longer the need for vasopressor(s), mechanical ventilation or RRT and the higher the need for fluid load (all p < 0.005). In patients with cDPP3 > 40.4 ng/mL upon admission, a decrease in cDPP3 below 40.4 ng/mL after 24 h was associated with an improvement of organ function at 48 h and better 28-day outcome. By contrast, persistently elevated cDPP3 at 24 h was associated with worsening organ function and high 28-day mortality. Conclusions Admission levels and rapid changes in cDPP3 predict outcome during sepsis. Trial Registration ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015.

In-hospital mortality and organ failure after open and endovascular thoraco-abdominal aortic surgery can be predicted by increased levels of circulating dipeptidyl peptidase 3

2020 ◽  
Author(s):  
Alexander Gombert ◽  
Mohammad Barbati ◽  
Drosos Kotelis ◽  
Tim-Philipp Simon ◽  
Thomas Breuer ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Organ Failure ◽  
Predictive Accuracy ◽  
Characteristic Curve ◽  
Aortic Surgery ◽  
Strong Association ◽  
Dipeptidyl Peptidase ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic ◽  
Dipeptidyl Peptidase 3

Abstract OBJECTIVES Endovascular and open thoraco-abdominal aortic aneurysm (TAAA) repair is associated with specific complications. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker that shows a strong association with organ failure which has not been assessed in surgical settings. Therefore, the objective of this study was to assess the prognostic capabilities of cDPP3 for predicting patient survival and organ failure following open and endovascular TAAA repair. METHODS Thirty-three patients undergoing TAAA repair were assessed in this prospective observational single-centre study. cDPP3 levels were serially measured perioperatively until 72 h after admission to the intensive care unit (ICU). In-hospital mortality and any organ failure were the clinical end points. RESULTS Postoperative organ failure was detected in 17 patients (51.5%), and 6 patients died after surgery (18.2%). At 12 h after admission to the ICU, cDPP3 levels were significantly increased in patients who died or developed organ failure (P &lt; 0.001). cDPP3 levels after surgery demonstrated a remarkable predictive accuracy for in-hospital mortality [12 h area under the receiver operating characteristic curve (AUC): 0.907 (P &lt; 0.001), 24 h AUC: 0.815 (P = 0.016), 48 h AUC: 0.914 (P = 0.003)] and the development of organ failure [12 h AUC: 0.882 (P &lt; 0.001), 24 h AUC: 0.850 (P &lt; 0.001), 48 h AUC: 0.846 (P &lt; 0.001)]. Additionally, a significant correlation between cDPP3, the sequential organ failure assessment score and procalcitonin, C-reactive protein and interleukin-6 levels (P &lt; 0.001, P &lt; 0.001, P = 0.011, P = 0.007, respectively) based on all available measurements and time points was observed. CONCLUSIONS The present findings highlight the role of cDPP3 as an early, highly specific postoperative biomarker for prediction of in-hospital mortality and organ failure after TAAA repair.

scholarly journals Identification of dipeptidyl peptidase 3 as the Angiotensin-(1–7) degrading peptidase in human HK-2 renal epithelial cells

Peptides ◽  
2016 ◽  
Vol 83 ◽  
pp. 29-37 ◽  
Author(s):  
Nildris Cruz-Diaz ◽  
Bryan A. Wilson ◽  
Nancy T. Pirro ◽  
K. Bridget Brosnihan ◽  
Allyson C. Marshall ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Dipeptidyl Peptidase ◽  
Renal Epithelial Cells ◽  
Dipeptidyl Peptidase 3

Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6

2002 ◽  
Vol 30 (9) ◽  
pp. 1987-1994 ◽  
Author(s):  
Alexander Geppert ◽  
Angela Steiner ◽  
Gerlinde Zorn ◽  
Georg Delle-Karth ◽  
Maria Koreny ◽  
...  
Keyword(s):  
Cardiogenic Shock ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
High Plasma ◽  
Multiple Organ

scholarly journals Dipeptidyl peptidase 3, a novel protease from Leishmania braziliensis

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190618 ◽  
Author(s):  
Jenny R. Diaz ◽  
Cesar A. Ramírez ◽  
Paola A. Nocua ◽  
Fanny Guzman ◽  
José M. Requena ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Leishmania Braziliensis ◽  
Dipeptidyl Peptidase 3

Dipeptidyl peptidase 3, a biomarker in cardiogenic shock and hopefully much more

2020 ◽  
Vol 22 (2) ◽  
pp. 300-302 ◽  
Author(s):  
Aurora Magliocca ◽  
Torbjørn Omland ◽  
Roberto Latini
Keyword(s):  
Cardiogenic Shock ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase 3

scholarly journals Differential expression of dipeptidyl peptidase 3 in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fallopian Tube ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Dipeptidyl Peptidase ◽  
High Grade ◽  
Primary Tumors ◽  
Ovarian Cancers ◽  
Dipeptidyl Peptidase 3

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding dipeptidyl peptidase 3, DPP3, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. DPP3 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. DPP3 expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of DPP3 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. DPP3 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

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