2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation

2005 ◽  
Vol 13 (6) ◽  
pp. 1969-1975 ◽  
Author(s):  
Barbara Stefańska ◽  
Maria M. Bontemps-Gracz ◽  
Ippolito Antonini ◽  
Sante Martelli ◽  
Małgorzata Arciemiuk ◽  
...  
Keyword(s):  
Cell Lines ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of sapinofuranones A,B and 1,2,3-triazole-sapinofuranone hybrids as cytotoxic agents

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 101501-101512 ◽  
Author(s):  
K. Siva Nagi Reddy ◽  
Gowravaram Sabitha ◽  
Y. Poornachandra ◽  
C. Ganesh Kumar
Keyword(s):  
Total Synthesis ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Synthesis And Biological Evaluation

The total synthesis of sapinofuranones A,B and ent-sapinofuranones A,B and L-factor and a series of novel 1,2,3-triazole-sapinofuranone hybrids is described and their cytotoxicity against four human cancer cell lines (A549, MDA-MB-231, DU145 and HepG2) was evaluated.

Synthesis and biological evaluation of novel pyrido[2,3-b]pyrazines inhibiting both erlotinib-sensitive and erlotinib-resistant cell lines

2013 ◽  
Vol 23 (22) ◽  
pp. 6152-6155 ◽  
Author(s):  
László Kékesi ◽  
Anna Sipos ◽  
Gábor Németh ◽  
János Pató ◽  
Nóra Breza ◽  
...  
Keyword(s):  
Cell Lines ◽  
Resistant Cell ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents

2016 ◽  
Vol 66 ◽  
pp. 145-159 ◽  
Author(s):  
Pritam Thapa ◽  
Tara Man Kadayat ◽  
Seojeong Park ◽  
Somin Shin ◽  
Til Bahadur Thapa Magar ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation
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