scholarly journals Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

2014 ◽  
Vol 22 (13) ◽  
pp. 3393-3404 ◽  
Author(s):  
Haijun Chen ◽  
Amy A. Mrazek ◽  
Xiaofu Wang ◽  
Chunyong Ding ◽  
Ye Ding ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stellate Cell ◽  
Pancreatic Fibrosis ◽  
Synthesis And Characterization ◽  
Pancreatic Stellate Cell ◽  
Design Synthesis ◽  
Proliferation In Vitro

Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis

1999 ◽  
Vol 117 (5) ◽  
pp. 1198-1204 ◽  
Author(s):  
Jianliang Zhu ◽  
Jian Wu ◽  
Edward Frizell ◽  
Shu-Ling Liu ◽  
Reza Bashey ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Stellate Cell ◽  
In Vivo Model ◽  
Proliferation In Vitro

scholarly journals Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability

2005 ◽  
Vol 25 (20) ◽  
pp. 8874-8886 ◽  
Author(s):  
Emanuela Colombo ◽  
Paola Bonetti ◽  
Eros Lazzerini Denchi ◽  
Paola Martinelli ◽  
Raffaella Zamponi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dna Damage ◽  
Genetic Alterations ◽  
Dna Integrity ◽  
Senescent Phenotype ◽  
Tumor Suppressive Function ◽  
Proliferation In Vitro

ABSTRACT Nucleophosmin (NPM) is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19Arf and is thought to be indispensable for ribogenesis, cell proliferation, and survival after DNA damage. The NPM gene is the most frequent target of genetic alterations in leukemias and lymphomas, though its role in tumorigenesis is unknown. We report here the first characterization of a mouse NPM knockout strain. Lack of NPM expression results in accumulation of DNA damage, activation of p53, widespread apoptosis, and mid-stage embryonic lethality. Fibroblasts explanted from null embryos fail to grow and rapidly acquire a senescent phenotype. Transfer of the NPM mutation into a p53-null background rescued apoptosis in vivo and fibroblast proliferation in vitro. Cells null for both p53 and NPM grow faster than control cells and are more susceptible to transformation by activated oncogenes, such as mutated Ras or overexpressed Myc. In the absence of NPM, Arf protein is excluded from nucleoli and is markedly less stable. Our data demonstrate that NPM regulates DNA integrity and, through Arf, inhibits cell proliferation and are consistent with a putative tumor-suppressive function of NPM.

Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-catenin signaling

2014 ◽  
Vol 277 (2) ◽  
pp. 210-220 ◽  
Author(s):  
Perumal MadanKumar ◽  
Perumal NaveenKumar ◽  
Samidurai Manikandan ◽  
Halagowder Devaraj ◽  
Sivasithamparam NiranjaliDevaraj
Keyword(s):  
Cell Proliferation ◽  
Liver Fibrosis ◽  
Stellate Cell ◽  
Chemically Induced ◽  
Proliferation In Vitro

Effects of retinoic acid steroidal analogs on human leukemic HL60 cell proliferation in vitro and on angiogenesis in vivo

2005 ◽  
Vol 16 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Evaggelia S. Arsenou ◽  
Evangelia P. Papadimitriou ◽  
Eleni Kliafa ◽  
Maria Hountala ◽  
Sotiris S. Nikolaropoulos
Keyword(s):  
Cell Proliferation ◽  
Retinoic Acid ◽  
Hl60 Cell ◽  
Proliferation In Vitro

scholarly journals Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo

1997 ◽  
Vol 51 (6) ◽  
pp. 1838-1846 ◽  
Author(s):  
Masashi Haraguchi ◽  
Mikio Okamura ◽  
Masayo Konishi ◽  
Yoshio Konishi ◽  
Nobuo Negoro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

Glucose Increases Human Beta Cell Proliferation In Vitro and In Vivo.

2010 ◽  
pp. P3-482-P3-482
Author(s):  
HE Levitt ◽  
TJ Cyphert ◽  
JL Pascoe ◽  
DA Hollern ◽  
N Abraham ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Beta Cell ◽  
Beta Cell Proliferation ◽  
Human Beta Cell ◽  
Proliferation In Vitro
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