Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

2006 ◽  
Vol 16 (7) ◽  
pp. 1799-1802 ◽  
Author(s):  
Kimberly O. Cameron ◽  
Bruce A. Lefker ◽  
Margaret Y. Chu-Moyer ◽  
David T. Crawford ◽  
Paul DaSilva Jardine ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
New Bone Formation ◽  
Receptor Agonists ◽  
Ep4 Receptor

scholarly journals A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

2005 ◽  
Vol 21 (4) ◽  
pp. 565-575 ◽  
Author(s):  
Hua Zhu Ke ◽  
D Todd Crawford ◽  
Hong Qi ◽  
Hollis A Simmons ◽  
Thomas A Owen ◽  
...  
Keyword(s):  
Bone Mass ◽  
Prostaglandin E2 ◽  
Ovariectomized Rats ◽  
Ep4 Receptor

scholarly journals A New Synthetic Steroid, Osaterone Acetate (TZP-4238), Increases Cortical Bone Mass and Strength by Enhancing Bone Formation in Ovariectomized Rats

1997 ◽  
Vol 12 (4) ◽  
pp. 590-597 ◽  
Author(s):  
Hiroaki Fuse ◽  
Seiji Fukumoto ◽  
Hideyuki Sone ◽  
Yoshiko Miyata ◽  
Tomoyuki Saito ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Cortical Bone ◽  
Ovariectomized Rats ◽  
Cortical Bone Mass

Effects of Vitamin D3 Metabolites in Ovariectomized Rats

1989 ◽  
Vol 17 (3) ◽  
pp. 243-248
Author(s):  
H. Orimo ◽  
C. Tsutsumi ◽  
N. Hosoya ◽  
Y. Maeda ◽  
H. Yamato ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Formation ◽  
Bone Mass ◽  
Dry Weight ◽  
Weight Basis ◽  
Ovariectomized Rats ◽  
Bone Gla Protein ◽  
Dihydroxyvitamin D ◽  
Vitamin D3 Metabolites ◽  
Stimulation Of

The effects of two vitamin D3 metabolites, 24 R,25-dihydroxyvitamin D3 and lα,25-dihydroxyvitamin D3, were investigated in ovariectomized rats. The amount of ash in the femur on a defatted dry weight basis was significantly greater in rats treated with 1 μg/kg 24 R,25-dihydroxyvitamin D3, or 0.01 or 0.1 μg/kg lα,25-dihydroxyvitamin D3 than in the controls. The concentration of bone gla protein in serum and amounts in the femur were significantly greater in rats treated with 1 or 10 Mg/kg 24 R,25-dihydroxyvitamin D3, but not those given 1α,25-dihydroxyvitamin D3 compared with the controls. These results suggest that 24 R,25-dihydroxyvitamin D3 increased bone mass probably through the stimulation of bone formation.

Young Coconut Juice Supplementation Results in Greater Bone Mass and Bone Formation Indices in Ovariectomized Rats: A Preliminary Study

2015 ◽  
Vol 29 (12) ◽  
pp. 1950-1955 ◽  
Author(s):  
Yuko Morii ◽  
Hiroshi Matsushita ◽  
Akira Minami ◽  
Hiroaki Kanazawa ◽  
Takashi Suzuki ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
Preliminary Study

scholarly journals Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats

Endocrinology ◽  
2011 ◽  
Vol 152 (9) ◽  
pp. 3312-3322 ◽  
Author(s):  
Xiaodong Li ◽  
Michael S. Ominsky ◽  
Kelly S. Warmington ◽  
Qing-Tian Niu ◽  
Franklin J. Asuncion ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Ovariectomized Rats ◽  
Sclerostin Antibody

Dietary fish oil results in a greater bone mass and bone formation indices in aged ovariectomized rats

2008 ◽  
Vol 26 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Hiroshi Matsushita ◽  
Jill A. Barrios ◽  
Jill E. Shea ◽  
Scott C. Miller
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Fish Oil ◽  
Ovariectomized Rats ◽  
Dietary Fish

Effect of High Local Concentrations of Antibiotics on Early Bone Formation with Tooth Ash and Plaster of Paris in the Ovariectomized Rat

2007 ◽  
Vol 330-332 ◽  
pp. 1311-1314 ◽  
Author(s):  
S.G. Kim ◽  
O.J. Park ◽  
Sung Chul Lim ◽  
Chun Sik Bae
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Clinical Effect ◽  
Antibiotic Use ◽  
Ovariectomized Rats ◽  
Histomorphometric Analysis ◽  
New Bone Formation ◽  
Plaster Of Paris ◽  
Significant Difference ◽  
Early Bone Formation

This studied determined the clinical effect of antibiotic use at the site of bone defect restoration in patients with osteoporosis, using tooth ash and plaster of Paris in ovariectomized rats. Forty-eight rats were assigned to four groups randomly and each group was further divided into 4 and 8 weeks after implantation. Histologic sections of the defects were obtained after surgery for histomorphometric analysis. Comparing each week, a significant difference was seen in bone formation by 4 weeks. Compared to controls, new bone formation increased significantly with tooth ash and saline, tooth ash and gentamicin, and tooth ash and gentamicin after ovariectomy. Tooth ash and saline resulted in the best bone formation. The degree of new bone formation was slightly lower when tooth ash and gentamicin were used compared to when tooth ash and saline were used. When tooth ash and gentamicin were compared according to ovariectomy, bone formation was significantly inhibited by ovariectomy at 4 weeks, while no significant difference was seen at 8 weeks.

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