scholarly journals Systemic Administration of Acidic Fibroblast Growth Factor (FGF-1) Prevents Bone Loss and Increases New Bone Formation in Ovariectomized Rats

1999 ◽  
Vol 14 (6) ◽  
pp. 953-959 ◽  
Author(s):  
C. R. Dunstan ◽  
R. Boyce ◽  
B. F. Boyce ◽  
I. R. Garrett ◽  
E. Izbicka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Loss ◽  
Bone Formation ◽  
Fibroblast Growth Factor ◽  
Systemic Administration ◽  
Ovariectomized Rats ◽  
Fibroblast Growth ◽  
New Bone Formation ◽  
Acidic Fibroblast Growth Factor

Systemic administration of acidic fibroblast growth factor ameliorates the ischemic injury of the retina in rats

1998 ◽  
Vol 255 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Pedro Cuevas ◽  
Fernando Carceller ◽  
Mariano Redondo-Horcajo ◽  
Rosa Maria Lozano ◽  
Guillermo Giménez-Gallego
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Ischemic Injury ◽  
Systemic Administration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

scholarly journals Protective Effects of Moderate Ca Supplementation against Cd-Induced Bone Damage under Different Population-Relevant Doses in Young Female Rats

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 849 ◽  
Author(s):  
Huang ◽  
Liu ◽  
Zhao ◽  
Fu ◽  
Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Young Female ◽  
Female Rats ◽  
Bone Biomechanics ◽  
Protective Effects ◽  
Fibroblast Growth ◽  
Bone Damage

Estimation of the skeleton-protective effects of Ca in Cd-induced bone damage is helpful in the assessment of Cd health risk. The aim of this study was to identify whether Ca supplementation during exposure to different population-relevant doses of Cd can prevent Cd-induced bone damage under the tolerable upper intake level of Ca supplementation. Young female Sprague-Dawley rats were given different population-relevant doses of Cd (1, 5, and 50 mg Cd/kg diet) and Ca supplementation (0.4% Ca supplementation) intervention. Ca supplementation significantly decreased Cd-induced bone microstructure damage, increased bone biomechanics (p < 0.05), serum bone formation marker level (p < 0.05) and expression of osteogenic gene markers exposure to the 5 and 50 mg Cd/kg diets. However, it had no impact on these indicators under the 1 mg Cd/kg diets, with the exception of expression of osteogenic marker genes. Ca supplementation significantly decreased serum Klotho level (p < 0.05), and fibroblast growth factor 23/Klotho-associated gene expression in the kidney and bone showed significant changes. In conclusion, Ca supplementation has a positive effect on bone formation and bone quality against the damaging impact of Cd, especially with exposure to the 5 mg and 50 mg Cd/kg diet, which may be related to its impact on the fibroblast growth factor 23/Klotho axis.

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