Contribution of fat mass and obesity-associated (FTO) gene to bone loss: The Dubbo osteoporosis epidemiology study

AbstractSeveral studies have shown that rs9939609 and rs1421085 in fat mass and obesity-associated (FTO) gene rs17782313 and rs12970134 in melanocortin-4 receptor (MC4R) gene influence obesity. In the present study, we aimed to determine association between rs9939609, rs1421085, rs17782313, and rs12970134 polymorphism, and their relation with body mass index (BMI), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and lipid values in obese children. We included 100 newly diagnosed obese children and 100 healthy children. The rs1421085 (CC/CT) (p = 0.019) and rs9939609 (AA/AT) (p = 0.002) polymorphism regions were higher in the obese group. Additionally, we found that both the rs1421085 (CC/CT) and rs9939609 (AA/AT) polymorphism associated with high-density lipoprotein cholesterol (p = 0.011 and p = 0.003) and triglycerides (p = 0.01 and p = 0.004) level, respectively. Further, the rs9939609 and rs1421085 variants of FTO gene associated with HDL-cholesterol and triglycerides levels in obese children; however, updated studies with a large sample size are required to establish strong links with genetic variants and risk factors in childhood obesity.

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Increasing body fat mass reverses bone loss in osteopenia as detected by dual-energy X-ray absorptiometry scans

European Journal of Rheumatology ◽

10.5152/eurjrheum.2015.0025 ◽

2016 ◽

Vol 3 (1) ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

William P. Hedges ◽

Marwan Bukhari

Keyword(s):

Bone Loss ◽

Body Fat ◽

Fat Mass ◽

Dual Energy ◽

Body Fat Mass ◽

X Ray

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Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle

Veterinary World ◽

10.14202/vetworld.2019.1160-1166 ◽

2019 ◽

Vol 12 (7) ◽

pp. 1160-1166

Author(s):

Amalia Puji Rahayu ◽

Tety Hartatik ◽

Agung Purnomoadi ◽

Edy Kurnianto

Keyword(s):

Fatty Acid ◽

Single Nucleotide Polymorphisms ◽

Fat Mass ◽

Milk Protein ◽

Fatty Acid Synthase ◽

Nucleotide Polymorphisms ◽

Fat Percentage ◽

Fto Gene ◽

Milk Traits ◽

Single Nucleotide

Aim: The study aimed to identify fatty acid synthase (FASN), LOC514211, and fat mass and obesity-associated (FTO) gene polymorphisms and to investigate their associations with milk traits in an Indonesian-Holstein dairy cow population. Materials and Methods: A total of 100 Indonesian-Holstein cows consisting of 50 heads (0th generation; G0) and 50 heads of their daughters (1st generation; G1) were used. Polymerase chain reaction-restriction fragment length polymorphism was performed to genotype three single nucleotide polymorphisms: rs41919985 in the FASN gene, rs42688595 in the LOC514211 gene, and g.1371T>A in the FTO gene. Results: FASN rs41919985 was associated with milk protein percentage (p<0.05), FTO g.1371T>A was associated with milk fat percentage (p<0.05), and LOC514211 rs42688595 was not associated with any trait (p>0.05). Heterozygote variants showed a higher protein percentage for FASN and the highest fat percentage for FTO. These associations were consistent in the G0 and G1 populations. Conclusion: Our results indicate that the milk protein and fat percentages can be improved by increasing the frequency of the AG genotype of FASN and the AT genotype of FTO, respectively.

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