Vertebral fractures and abdominal aortic calcification in postmenopausal women. A cohort study

Bone ◽  
2013 ◽  
Vol 56 (1) ◽  
pp. 213-219 ◽  
Author(s):  
A. El Maghraoui ◽  
A. Rezqi ◽  
A. Mounach ◽  
L. Achemlal ◽  
A. Bezza ◽  
...  
Keyword(s):  
Cohort Study ◽  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

scholarly journals Influence of Homocysteine and Vertebral Fractures on prevalent Abdominal Aortic Calcification in Postmenopausal Women: A multicentric cross-sectional study

2017 ◽  
Vol 4 (r) ◽  
Author(s):  
Imad GHOZLANI ◽  
Aissam EL MAATAOUI ◽  
Aziza MOUNACH ◽  
Mirieme GHAZI ◽  
Anass KHERRAB ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Plasma Homocysteine ◽  
Aortic Calcification ◽  
Vertebral Fracture Assessment ◽  
Study Cohort ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
Osteoporotic Vertebral Fractures

The main of this study was to examine the relationship between plasma homocysteine (Hcy), asymptomatic osteoporotic vertebral fractures (VFs) using vertebral fracture assessment (VFA) and prevalent abdominal aortic calcification (AAC) in Moroccan postmenopausal women. The study cohort consisted of 188 consecutive postmenopausal women with no prior known diagnosis of osteoporosis or taking medication interfering with bone metabolism. Mean age, weight, height, body mass index and plasma homocysteine were determined. Lateral VFA images and scans of the lumbar spine and proximal femur were obtained using a Lunar Prodigy Vision densitometer (GE Healthcare Inc., Waukesha, WI). VFs were defined using a combination of Genant’s semiquantitative approach and morphometry. VFA images were also scored for prevalent AAC using a validated 24 point scale. Fifty-eight (30.9%) patients had densitometric osteoporosis. VFs were identified using VFA in 76 (40.4%) patients: 61 women had grade 1 VFs and 15 had grade 2 or 3 VFs. One hundred twenty nine women (68.6%) did not have any detectable AAC, whereas the prevalence of significant atherosclerotic burden defined as AAC score of 5 or higher, was 13.8%. A significant positive correlation between AAC score and homocysteine was observed. Women with extended AAC, were older, had a lower weight, BMI and BMD, higher homocysteine levels and more prevalent VFs than women without extended AAC. Multiple regression analysis showed that the presence of extended AAC was significantly associated with Age and grade 2/3 VFs and not independently associated with homocysteine levels. This study did not confirm that homocysteine is important determinant of extended AAC in postmenopausal women. However, this significant atherosclerotic marker is independently associated with VFs regardless of age

scholarly journals Comparison of QCT and DXA: Osteoporosis Detection Rates in Postmenopausal Women

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Na Li ◽  
Xin-min Li ◽  
Li Xu ◽  
Wei-jie Sun ◽  
Xiao-guang Cheng ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Detection Rate ◽  
Aortic Calcification ◽  
Mineral Density ◽  
Abdominal Aortic Calcification ◽  
Detection Rates ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
Spinal Degeneration

Objective. To compare the osteoporosis detection rates in postmenopausal women when measuring bone mineral density (BMD) with quantitative computed tomography (QCT) in the spine versus dual X-ray absorptiometry (DXA) in the spine and hip and to investigate the reasons for the discrepancy between the two techniques.Methods. Spinal volumetric BMD was measured with QCT, and areal spinal and hip BMDs were measured with DXA in 140 postmenopausal women. We calculated the osteoporosis detection rate for the two methods. Lumbar CT images of patients who had a discrepancy between QCT and DXA findings were reviewed to evaluate vertebral fractures, spinal degeneration, and abdominal aortic calcification.Results. For the entire 140 patients, the detection rate was 17.1% for DXA and 46.4% for QCT, a significant difference (P< 0.01). Of the 41 patients with conflicting diagnoses, 7 whose diagnosis by QCT was osteoporosis had vertebral fractures even though their DXA findings did not indicate osteoporosis. Varying degrees of spinal degeneration were seen in all of the 41 patients.Conclusion. QCT may avoid the overestimation of BMD by DXA associated with spinal degeneration, abdominal aortic calcification, and other sclerotic lesions. It may be more sensitive than DXA for detecting osteoporosis in postmenopausal women.

scholarly journals A Radiographic Study on the Associations of Age and Prevalence of Vertebral Fractures with Abdominal Aortic Calcification in Japanese Postmenopausal Women and Men

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Iwamoto ◽  
Hideo Matsumoto ◽  
Tsuyoshi Takeda ◽  
Yoshihiro Sato ◽  
Mitsuyoshi Uzawa
Keyword(s):  
Hip Fracture ◽  
Vertebral Fracture ◽  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Exercise Program ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
History Of ◽  
Vertebral Bodies

The purpose of the present study was to determine the associations of age and history of non- and low-traumatic fractures with the severity of abdominal aortic calcification in Japanese postmenopausal women and men. Four hundred and one Japanese persons (24 men and 377 postmenopausal women, mean age: 73.8 years) for whom thoracic and lumbar spine radiographs had been obtained to evaluate their posture prior to patient participation in a fall-prevention exercise program were enrolled. The associations of sex, age, history of hip fracture, prevalence of vertebral fracture, and spondylosis grade (the Nathan degree) with the severity of abdominal aortic calcification (length of calcification, as evaluated according to the number of vertebral bodies) were analyzed. Nine subjects (2.2%) had a history of hip fracture, and 221 (55.1%) had at least one prevalent vertebral fracture. Two hundred and sixty-seven subjects (66.6%) had first-degree spondylosis. Age and the number of prevalent vertebral fractures, but not sex, history of hip fracture, or spondylosis grade, were significantly associated with the severity of abdominal aortic calcification. The present study confirmed that age and the number of vertebral fractures were associated with the severity of abdominal aortic calcification in Japanese postmenopausal women and men.

Association between abdominal aortic calcification and osteoporosis in postmenopausal women in Beijing

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S364-S365
Author(s):  
Ningyi Cui ◽  
Weibo Xia ◽  
Yan Jiang ◽  
Qiang Lin ◽  
Wei Yu ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

scholarly journals High prevalence of abdominal aortic calcification in patients with primary hyperparathyroidism as evaluated by Kauppila score

2016 ◽  
Vol 175 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Jessica Pepe ◽  
Daniele Diacinti ◽  
Emanuela Fratini ◽  
Italo Nofroni ◽  
Antonella D’Angelo ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Postmenopausal Women ◽  
Aortic Calcification ◽  
Mineral Density ◽  
Abdominal Aortic Calcification ◽  
Lateral Spine ◽  
Abdominal Aortic ◽  
Hormone Effect ◽  
Spine Radiograph

Objective The prevalence of abdominal aortic calcification (AAC) in primary hyperparathyroidism (PHPT) is unknown. We assessed both prevalence and severity of AAC in PHPT postmenopausal women. Methods In this study 70 PHPT postmenopausal women and 70 age- and sex-matched controls were enrolled. Each participant underwent biochemical evaluation, lateral spine radiograph, bone mineral density (BMD) measurement (lumbar, femoral, radial sites), and kidney ultrasound. Lateral lumbar films were analyzed in the region of L1–L4 vertebrae and the Kauppila score (a semi-quantitative grading system) was used to assess the severity of AAC. Results There were no differences regarding demographic and cardiovascular risk factors in the two groups. PHPT patients had higher prevalence of kidney stones (30% vs 7%, P=0.0008) and lower radial BMD values (0.558±0.071 vs 0.588±0.082 g/cm2, P<0.05) compared with controls. PHPT patients showed higher prevalence of AAC (31 vs 18, P=0.03), with more severe calcifications (Kauppila score 7.35±6.1 vs 5.05±3.5, P=0.007). PHPT patients with AAC were older and had been suffering from the disease for a longer period compared with those without ACC. Moreover, PHPT patients with severe AAC had mean higher serum parathyroid hormone levels compared with patients with moderate or mild calcifications. In PHPT patients with AAC, multiple regression analysis, adjusted for age and years since diagnosis, showed that only parathyroid hormone significantly correlated with Kauppila score. Conclusion We found a higher prevalence and severity of AAC in PHPT related to parathyroid hormone effect.

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