scholarly journals Influence of Homocysteine and Vertebral Fractures on prevalent Abdominal Aortic Calcification in Postmenopausal Women: A multicentric cross-sectional study

2017 ◽  
Vol 4 (r) ◽  
Author(s):  
Imad GHOZLANI ◽  
Aissam EL MAATAOUI ◽  
Aziza MOUNACH ◽  
Mirieme GHAZI ◽  
Anass KHERRAB ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Plasma Homocysteine ◽  
Aortic Calcification ◽  
Vertebral Fracture Assessment ◽  
Study Cohort ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
Osteoporotic Vertebral Fractures

The main of this study was to examine the relationship between plasma homocysteine (Hcy), asymptomatic osteoporotic vertebral fractures (VFs) using vertebral fracture assessment (VFA) and prevalent abdominal aortic calcification (AAC) in Moroccan postmenopausal women. The study cohort consisted of 188 consecutive postmenopausal women with no prior known diagnosis of osteoporosis or taking medication interfering with bone metabolism. Mean age, weight, height, body mass index and plasma homocysteine were determined. Lateral VFA images and scans of the lumbar spine and proximal femur were obtained using a Lunar Prodigy Vision densitometer (GE Healthcare Inc., Waukesha, WI). VFs were defined using a combination of Genant’s semiquantitative approach and morphometry. VFA images were also scored for prevalent AAC using a validated 24 point scale. Fifty-eight (30.9%) patients had densitometric osteoporosis. VFs were identified using VFA in 76 (40.4%) patients: 61 women had grade 1 VFs and 15 had grade 2 or 3 VFs. One hundred twenty nine women (68.6%) did not have any detectable AAC, whereas the prevalence of significant atherosclerotic burden defined as AAC score of 5 or higher, was 13.8%. A significant positive correlation between AAC score and homocysteine was observed. Women with extended AAC, were older, had a lower weight, BMI and BMD, higher homocysteine levels and more prevalent VFs than women without extended AAC. Multiple regression analysis showed that the presence of extended AAC was significantly associated with Age and grade 2/3 VFs and not independently associated with homocysteine levels. This study did not confirm that homocysteine is important determinant of extended AAC in postmenopausal women. However, this significant atherosclerotic marker is independently associated with VFs regardless of age

Vertebral fractures and abdominal aortic calcification in postmenopausal women. A cohort study

Bone ◽  
2013 ◽  
Vol 56 (1) ◽  
pp. 213-219 ◽  
Author(s):  
A. El Maghraoui ◽  
A. Rezqi ◽  
A. Mounach ◽  
L. Achemlal ◽  
A. Bezza ◽  
...  
Keyword(s):  
Cohort Study ◽  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

scholarly journals Comparison of QCT and DXA: Osteoporosis Detection Rates in Postmenopausal Women

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Na Li ◽  
Xin-min Li ◽  
Li Xu ◽  
Wei-jie Sun ◽  
Xiao-guang Cheng ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Detection Rate ◽  
Aortic Calcification ◽  
Mineral Density ◽  
Abdominal Aortic Calcification ◽  
Detection Rates ◽  
Abdominal Aortic ◽  
Significant Difference ◽  
Spinal Degeneration

Objective. To compare the osteoporosis detection rates in postmenopausal women when measuring bone mineral density (BMD) with quantitative computed tomography (QCT) in the spine versus dual X-ray absorptiometry (DXA) in the spine and hip and to investigate the reasons for the discrepancy between the two techniques.Methods. Spinal volumetric BMD was measured with QCT, and areal spinal and hip BMDs were measured with DXA in 140 postmenopausal women. We calculated the osteoporosis detection rate for the two methods. Lumbar CT images of patients who had a discrepancy between QCT and DXA findings were reviewed to evaluate vertebral fractures, spinal degeneration, and abdominal aortic calcification.Results. For the entire 140 patients, the detection rate was 17.1% for DXA and 46.4% for QCT, a significant difference (P< 0.01). Of the 41 patients with conflicting diagnoses, 7 whose diagnosis by QCT was osteoporosis had vertebral fractures even though their DXA findings did not indicate osteoporosis. Varying degrees of spinal degeneration were seen in all of the 41 patients.Conclusion. QCT may avoid the overestimation of BMD by DXA associated with spinal degeneration, abdominal aortic calcification, and other sclerotic lesions. It may be more sensitive than DXA for detecting osteoporosis in postmenopausal women.

scholarly journals A Radiographic Study on the Associations of Age and Prevalence of Vertebral Fractures with Abdominal Aortic Calcification in Japanese Postmenopausal Women and Men

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Iwamoto ◽  
Hideo Matsumoto ◽  
Tsuyoshi Takeda ◽  
Yoshihiro Sato ◽  
Mitsuyoshi Uzawa
Keyword(s):  
Hip Fracture ◽  
Vertebral Fracture ◽  
Postmenopausal Women ◽  
Vertebral Fractures ◽  
Exercise Program ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
History Of ◽  
Vertebral Bodies

The purpose of the present study was to determine the associations of age and history of non- and low-traumatic fractures with the severity of abdominal aortic calcification in Japanese postmenopausal women and men. Four hundred and one Japanese persons (24 men and 377 postmenopausal women, mean age: 73.8 years) for whom thoracic and lumbar spine radiographs had been obtained to evaluate their posture prior to patient participation in a fall-prevention exercise program were enrolled. The associations of sex, age, history of hip fracture, prevalence of vertebral fracture, and spondylosis grade (the Nathan degree) with the severity of abdominal aortic calcification (length of calcification, as evaluated according to the number of vertebral bodies) were analyzed. Nine subjects (2.2%) had a history of hip fracture, and 221 (55.1%) had at least one prevalent vertebral fracture. Two hundred and sixty-seven subjects (66.6%) had first-degree spondylosis. Age and the number of prevalent vertebral fractures, but not sex, history of hip fracture, or spondylosis grade, were significantly associated with the severity of abdominal aortic calcification. The present study confirmed that age and the number of vertebral fractures were associated with the severity of abdominal aortic calcification in Japanese postmenopausal women and men.

scholarly journals Osteocalcin and Abdominal Aortic Calcification in Hemodialysis Patients: An Observational Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Fengyu Jia ◽  
Suxia Wang ◽  
Ying Jing ◽  
Hanhui Zhao ◽  
Peng Rong ◽  
...  
Keyword(s):  
Vascular Calcification ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Aortic Calcification ◽  
Maintenance Hemodialysis ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic

ObjectivesTo investigate the serum level of osteocalcin (OC), also known as bone Gla protein, in maintenance hemodialysis (MHD) patients and its correlation with abdominal aortic calcification (AAC).MethodsFrom July 2017 to February 2020, we enrolled 108 adult MHD patients. Routine fasting blood laboratory tests were performed before the start of the second hemodialysis in a week. Abdominal aortic calcification score (AACs) was assessed within 1 month. Pearson correlation and Logistic regression were used to analyze the data.ResultsThe OC level was 231.56 (25.92,361.33) ng/ml, elevating significantly in this group of MHD patients. It had a positive correlation with serum phosphorus (r = 0.511, P = 0.001), intact parathyroid hormone(iPTH) (r = 0.594, P = 0.0001), fibroblast growth factor 23(FGF23) (r = 0.485, P = 0.003) and a negative correlation with age(r = -0.356, P = 0.039). Based on the AACs, patients were divided into two groups. Serum OC level were higher in patients with AACs≥5 (p=0.032). A multiple logistics regression analysis revealed that age (odds ratio [OR]1.14, P=0.005) and OC(OR=1.10, P=0.008)were risk factors for high AACs(≥5).ConclusionThe study implicated that OC elevated significantly in this group of MHD patients.OC is positively correlated with phosphorus, iPTH, FGF23, and a negative correlation with age. OC was a risk factor for vascular calcification in this study, but this study did not classify osteocalcin as c-OC and unOC. Whether unOC is associated more directly with vascular calcification requires further study.

scholarly journals Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

2011 ◽  
Vol 129 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Daniela Fodor ◽  
Cosmina Bondor ◽  
Adriana Albu ◽  
Laura Muntean ◽  
Siao-pin Simon ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Atherosclerotic Plaque ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
Cross Sectional ◽  
T Score ◽  
Osteoporotic Vertebral Fractures ◽  
The Relationship

CONTEXT AND OBJECTIVES: Controversy exists regarding the relationship between atherosclerosis and osteoporosis. The aim of this study was to determine the relationship between intima-media thickness (IMT) of the common carotid artery (CCA), presence of calcified atherosclerotic plaques and bone mineral density (BMD) evaluated by dual energy X-ray absorptiometry (DXA), in postmenopausal women. DESIGN AND SETTING: Cross-sectional study at Second Internal Medicine Clinic, Cluj-Napoca, Romania. METHODS: We studied the IMT (left and right CCA and mean IMT) and T-score (lumbar spine L2-L4, femoral neck and total hip) in 100 postmenopausal women (mean age 64.5 years). The presence of calcified atherosclerotic plaque and osteoporotic vertebral fractures was also noted. RESULTS: IMT in the left and right CCA and mean IMT were significantly associated with T-score measured for the lumbar spine L2-L4, femoral neck and total hip, with lower T-score, in the osteoporotic group than in the normal and osteopenic groups (P < 0.05). IMT had a significantly negative correlation with the lumbar spine T-score and femoral neck T-score; and mean IMT with lowest T-score. Mean IMT (P < 0.001), high blood pressure (P = 0.005) and osteoporotic vertebral fractures (P = 0.048) showed statistical significance regarding the likelihood of developing atherosclerotic plaque. CONCLUSIONS: In women referred for routine osteoporosis screening, the relationship between CCA, atherosclerosis and osteoporosis can be demonstrated using either cortical or trabecular BMD. Vertebral fractures may be considered to be a likelihood factor for atherosclerotic plaque development.

Association between abdominal aortic calcification and osteoporosis in postmenopausal women in Beijing

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S364-S365
Author(s):  
Ningyi Cui ◽  
Weibo Xia ◽  
Yan Jiang ◽  
Qiang Lin ◽  
Wei Yu ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic
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