Strain-specific alterations in the skeletal response to adenine-induced chronic kidney disease are associated with differences in parathyroid hormone levels

Bone ◽  
2021 ◽  
pp. 115963
Author(s):  
Corinne E. Metzger ◽  
Elizabeth A. Swallow ◽  
Alexander J. Stacy ◽  
Matthew R. Allen
Nephrology ◽  
2007 ◽  
Vol 0 (0) ◽  
pp. 070918212946008-??? ◽  
Author(s):  
ARISTEIDIS STAVROULOPOULOS ◽  
CHRISTINE J PORTER ◽  
SIMON D ROE ◽  
DAVID J HOSKING ◽  
MICHAEL JD CASSIDY

2021 ◽  
Vol 9 (B) ◽  
pp. 470-474
Author(s):  
Sianny Herawati ◽  
Yenny Kandarini ◽  
I Putu Yuda Prabawa

BACKGROUND: Chronic kidney disease (CKD) is a structural or functional kidney disease for more than 3 months. In predialysis CKD patients, the serum parathyroid hormone levels increase progressively since the early stages of the disease to maintain phosphate homeostasis. Glomerular filtration rate (GFR) has been widely accepted to assess renal function. The GFR assessment is used to determine the CKD stadium. AIM: This study aims to analyze the correlation between GFR and parathyroid hormone levels in predialysis CKD patients undergoing treatment at Sanglah General Hospital Denpasar. METHODS: A cross-sectional observational study was conducted among predialysis CKD patients undergoing treatment at Sanglah General Hospital Denpasar who met the inclusion and exclusion criteria. The inclusion criteria were adult patients (≥18 years) who were accepting to participate in the study. Exclusion criteria were patients with predialysis CKD after thyroidectomy and/or parathyroidectomy and liver disease. The parathyroid hormone levels, blood urea nitrogen, creatinine, and GFR were examined and analyzed by SPSS version 17 for Windows. RESULTS: A total of 77 patients with predialysis CKD in this study obtained a median of e-GFR of 21.09 (4.72–75.80) mL/min/1.73 m2. The median level of parathyroid hormone was 82.07 pg/mL (15.83–716.60 pg/mL). Spearman’s correlation analysis results obtained a strong and significant negative correlation between the e-GFR value and parathyroid hormone levels (r = −0.540; p = 0.000). CONCLUSION: The parathyroid hormone levels assessment could be used as a recommendation in evaluating the CKD progressivity among predialysis adult patients at Sanglah General Hospital, Bali, Indonesia, due to the strong significant correlation.


2020 ◽  
Vol Volume 13 ◽  
pp. 341-348
Author(s):  
Raimunda Sheyla Carneiro Dias ◽  
Dyego José de Araújo Brito ◽  
Elisângela Milhomem dos Santos ◽  
Rayanna Cadilhe de Oliveira Costa ◽  
Andrea Martins Melo Fontenele ◽  
...  

Metabolism ◽  
2010 ◽  
Vol 59 (3) ◽  
pp. 385-389 ◽  
Author(s):  
Georges Saab ◽  
Adam Whaley-Connell ◽  
Samy I. McFarlane ◽  
Suying Li ◽  
Shu-Cheng Chen ◽  
...  

2020 ◽  
Vol 17 (4) ◽  
pp. 1145
Author(s):  
Mohanad Radeef

This study designed to examine association between-174G/C polymorphism of interleukin-6 gene and phosphate, calcium, vitamin D3, and parathyroid hormone levels in Iraqi patient with chronic kidney disease on maintenance hemodialysis. Seventy chronic renal failure patients (patients group) and 20 healthy subjects (control group) were genotyped for interleukin-6 polymorphism and genotyping was performed by conventional polymerase chain reaction-restriction fragment length polymorphism. No significant differences in phosphate levels were observed in patients and control with different interleukin-6 genotypes. Control had non-significant differences in calcium levels, while patients with GG and CG genotypes displayed significant elevation with time. Conversely, control and patients with GG and CC genotypes had significant elevation in vitamin D3 levels with time. Regarding parathyroid hormone, control had non-significant differences, while patients with GG and CC genotypes displayed significant elevation with time. Patients with GG genotype displayed significant changes in calcium, vitamin D3 and parathyroid hormone levels with time.


2011 ◽  
Vol 1 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Georges Saab ◽  
Adam Whaley-Connell ◽  
Andrew Bombeck ◽  
Manjula Kurella Tamura ◽  
Suying Li ◽  
...  

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