scholarly journals A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss

Bone ◽  
2021 ◽  
pp. 116258
Author(s):  
Mikkel Bo Brent
Keyword(s):  
Bone Loss ◽  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Skeletal Effects

Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude natives

2006 ◽  
Vol 341 (4) ◽  
pp. 1218-1224 ◽  
Author(s):  
Charu Rajput ◽  
Shehla Najib ◽  
Tsering Norboo ◽  
Farhat Afrin ◽  
M.A. Qadar Pasha
Keyword(s):  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Gene Variants ◽  
Endothelin 1 ◽  
High Altitude Natives

Elevated plasma S100B levels in high altitude hypobaric hypoxia do not correlate with acute mountain sickness

2014 ◽  
Vol 36 (9) ◽  
pp. 779-785 ◽  
Author(s):  
Craig D. Winter ◽  
Timothy R. Whyte ◽  
John Cardinal ◽  
Stephen E. Rose ◽  
Peter K. O’Rourke ◽  
...  
Keyword(s):  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Acute Mountain Sickness ◽  
Elevated Plasma ◽  
Mountain Sickness

scholarly journals Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Jan Grimminger ◽  
Manuel Richter ◽  
Khodr Tello ◽  
Natascha Sommer ◽  
Henning Gall ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Current Knowledge ◽  
Treatment Options ◽  
Acute Response ◽  
Mechanisms Of Adaptation ◽  
Mountain Sickness

With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review summarizes current knowledge of the body’s acute response to these circumstances, possible complications and their treatment, and health care issues resulting from long-term exposure to high altitude. It furthermore describes the characteristic mechanisms of adaptation to life in hypobaric hypoxia expressed by the three major ethnic groups permanently dwelling at high altitude. We additionally summarize current knowledge regarding possible treatment options for hypoxia-induced pulmonary hypertension by reviewing in vitro, rodent, and human studies in this area of research.

Diseases of high terrestrial altitudes

2010 ◽  
pp. 1402-1408
Author(s):  
Andrew J. Pollard ◽  
Buddha Basnyat ◽  
David R. Murdoch
Keyword(s):  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Cell Mass ◽  
Red Cell ◽  
Physiological Changes ◽  
Exposed Individual ◽  
Extreme Altitude ◽  
First Arrival ◽  
The Individual ◽  
Over Time

Ascent to altitudes above 2500 m leads to exposure to hypobaric hypoxia. This affects performance on first arrival at high altitude and disturbs sleep, but physiological changes occur over time to defend arterial and tissue oxygenation and allow the individual to adjust. This process of acclimatization includes (1) an increase in the rate and depth of breathing; and (2) an increase in red cell mass, and in red cell 2,3-diphosphoglycerate. Acclimatization is no longer possible at extreme altitude (>5800 m) and the exposed individual will gradually deteriorate....

Angus calves born and raised at high altitude adapt to hypobaric hypoxia by increasing alveolar ventilation rate but not hematocrit1

2016 ◽  
Vol 94 (10) ◽  
pp. 4167-4171 ◽  
Author(s):  
A. K. Gulick ◽  
F. B. Garry ◽  
T. N. Holt ◽  
K. Retallick-Trennepohl ◽  
R. M. Enns ◽  
...  
Keyword(s):  
High Altitude ◽  
Hypobaric Hypoxia ◽  
Ventilation Rate ◽  
Alveolar Ventilation
Sign in / Sign up

Export Citation Format

Share Document