The effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation process

2017 ◽  
Vol 229 ◽  
pp. 110-114 ◽  
Author(s):  
F. Stellato ◽  
Z. Fusco ◽  
R. Chiaraluce ◽  
V. Consalvi ◽  
S. Dinarelli ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Aggregation Process ◽  
Β Sheet

scholarly journals β-Hairpin mimics containing a piperidine–pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species

2017 ◽  
Vol 8 (2) ◽  
pp. 1295-1302 ◽  
Author(s):  
S. Pellegrino ◽  
N. Tonali ◽  
E. Erba ◽  
J. Kaffy ◽  
M. Taverna ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Aggregation Process ◽  
Amyloid Aggregation ◽  
Protein Protein Interactions ◽  
Β Amyloid

Acyclic β-hairpins designed on oligomeric and fibril structures of Aβ1–42 disrupt protein–protein interactions mediating amyloid β-peptide aggregation.

Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide

2015 ◽  
Vol 51 (12) ◽  
pp. 2245-2248 ◽  
Author(s):  
Ashim Paul ◽  
Krishna Chaitanya Nadimpally ◽  
Tanmay Mondal ◽  
Kishore Thalluri ◽  
Bhubaneswar Mandal
Keyword(s):  
Anthranilic Acid ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Hybrid Peptide ◽  
Conformationally Restricted ◽  
Β Sheet

A novel class of anthranilic acid containing a conformationally restricted β-sheet breaker α/β-hybrid peptide efficiently disrupts preformed fibrillar aggregates of Aβ1–40in vitro.

Specific Binding of a β-Cyclodextrin Dimer to the Amyloid β Peptide Modulates the Peptide Aggregation Process

Biochemistry ◽  
2012 ◽  
Vol 51 (21) ◽  
pp. 4280-4289 ◽  
Author(s):  
Anna Wahlström ◽  
Risto Cukalevski ◽  
Jens Danielsson ◽  
Jüri Jarvet ◽  
Hideki Onagi ◽  
...  
Keyword(s):  
Specific Binding ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Aggregation Process ◽  
Cyclodextrin Dimer

Modulation of amyloid β peptide aggregation by hydrophilic polymers

2019 ◽  
Vol 21 (37) ◽  
pp. 20999-21006
Author(s):  
Zhanna Evgrafova ◽  
Bruno Voigt ◽  
Andreas H. Roos ◽  
Gerd Hause ◽  
Dariush Hinderberger ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Hydrophilic Polymers ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Amyloidogenic Protein

Careful balance of hydrophilicity of precisely engineered polymers alters aggregation of the amyloidogenic protein Aβ1–40.

scholarly journals Inhibition of metal-induced amyloid β-peptide aggregation by a blood–brain barrier permeable silica–cyclen nanochelator

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14126-14131 ◽  
Author(s):  
Jinzhuan Wang ◽  
Kun Wang ◽  
Zhenzhu Zhu ◽  
Yafeng He ◽  
Changli Zhang ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Blood Brain

A BBB-passable nanoscale silica–cyclen chelator effectively reduces the metal-induced Aβ aggregates and related ROS, thereby decreasing the neurotoxicity of Aβ.

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