Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment

2009 ◽  
Vol 1286 ◽  
pp. 208-214 ◽  
Author(s):  
Joo-Yong Lee ◽  
Hyo Jin Son ◽  
Ji Hyun Choi ◽  
Eunsil Cho ◽  
Jean Kim ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Zinc Accumulation ◽  
Mptp Treatment

Lactoferrin is Synthesized by Mouse Brain Tissue and Its Expression is Enhanced after MPTP Treatment

1998 ◽  
pp. 293-300 ◽  
Author(s):  
Carine Fillebeen ◽  
David Dexter ◽  
Valérie Mitchell ◽  
Monique Benaissa ◽  
Jean-Claude Beauvillain ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Mouse Brain ◽  
Mptp Treatment

scholarly journals Strain- and age-dependent features of the nigro-striatal circuit in three common laboratory mouse strains, C57BL/6J, A/J, and DBA/2J - Implications for Parkinson’s disease modeling

2020 ◽  
Author(s):  
Mélanie H. Thomas ◽  
Mona Karout ◽  
Beatriz Pardo Rodriguez ◽  
Yujuan Gui ◽  
Christian Jaeger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Mouse Strains ◽  
List Type ◽  
Background Strain ◽  
Age Related ◽  
Health And Disease ◽  
Over Time

AbstractMouse models have been instrumental in understanding genetic determinants of aging and its crucial role in neurodegenerative diseases. However, few studies have analyzed the evolution of the mouse brain over time at baseline. Furthermore, mouse brain studies are commonly conducted on the C57BL/6 strain, limiting the analysis to a specific genetic background. In Parkinson’s disease, the gradual demise of nigral dopaminergic neurons mainly contributes to the motor symptoms. Interestingly, a decline of the dopaminergic neuron function and integrity is also a characteristic of physiological aging in some species. Age-related nigro-striatal features have never been studied in mice of different genetic backgrounds. In this study, we analyze the morphological features in the striatum of three common mouse strains, C57BL/6J, A/J, and DBA/2J at 3-, 9- and 15 months of age. By measuring dopaminergic markers, we uncover age-related changes that differ between strains and evolve dynamically over time. Overall, our results highlight the importance of considering background strain and age when studying the murine nigro-striatal circuit in health and disease.HighlightsStudy of the integrity of the nigro-striatal circuit in C57BL/6J, A/J, and DBA/2J at different agesAge related evolution of essential features of nigral dopaminergic neurons differ between strainsConsider background strain and age is crutial to study the nigrostriatal circuit in health and disease

Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain

2006 ◽  
Vol 544 (1-3) ◽  
pp. 1-9 ◽  
Author(s):  
Lin Zhang ◽  
Yukihiko Shirayama ◽  
Eiji Shimizu ◽  
Masaomi Iyo ◽  
Kenji Hashimoto
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Protective Effects

Clioquinol Reduces Zinc Accumulation in Neuritic Plaques and Inhibits the Amyloidogenic Pathway in AβPP/PS1 Transgenic Mouse Brain

2012 ◽  
Vol 29 (3) ◽  
pp. 549-559 ◽  
Author(s):  
Tao Wang ◽  
Chun-Yan Wang ◽  
Zhong-Yan Shan ◽  
Wei-Ping Teng ◽  
Zhan-You Wang
Keyword(s):  
Transgenic Mouse ◽  
Mouse Brain ◽  
Neuritic Plaques ◽  
Zinc Accumulation

MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic neurons in mouse substantia nigra

1989 ◽  
Vol 501 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Alessandro Zuddas ◽  
Giovanni U. Corsini ◽  
Sergio Schinelli ◽  
Jan N. Johannessen ◽  
Umberto di Porzio ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Mptp Treatment

A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain

1999 ◽  
Vol 851 (1-2) ◽  
pp. 125-132 ◽  
Author(s):  
Cristina Bäckman ◽  
Thomas Perlmann ◽  
Åsa Wallén ◽  
Barry J Hoffer ◽  
Marisela Morales
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Adult Mouse ◽  
Adult Mouse Brain

scholarly journals Deciduous DPSCs Ameliorate MPTP-Mediated Neurotoxicity, Sensorimotor Coordination and Olfactory Function in Parkinsonian Mice

2019 ◽  
Vol 20 (3) ◽  
pp. 568 ◽  
Author(s):  
Christopher Simon ◽  
Quan Gan ◽  
Premasangery Kathivaloo ◽  
Nur Mohamad ◽  
Jagadeesh Dhamodharan ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Neurodegenerative Disorder ◽  
Therapeutic Potential ◽  
Olfactory Function ◽  
Substantia Nigra Pars Compacta ◽  
Sensorimotor Coordination ◽  
Cell Based Therapy ◽  
Effective Delivery ◽  
Mptp Treatment ◽  
The Many

Parkinson’s disease (PD) is a neurodegenerative disorder defined by progressive deterioration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Dental pulp stem cells (DPSCs) have been proposed to replace the degenerated dopaminergic neurons due to its inherent neurogenic and regenerative potential. However, the effective delivery and homing of DPSCs within the lesioned brain has been one of the many obstacles faced in cell-based therapy of neurodegenerative disorders. We hypothesized that DPSCs, delivered intranasally, could circumvent these challenges. In the present study, we investigated the therapeutic efficacy of intranasally administered DPSCs in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Human deciduous DPSCs were cultured, pre-labelled with PKH 26, and intranasally delivered into PD mice following MPTP treatment. Behavioural analyses were performed to measure olfactory function and sensorimotor coordination, while tyrosine hydroxylase (TH) immunofluorescence was used to evaluate MPTP neurotoxicity in SNpc neurons. Upon intranasal delivery, degenerated TH-positive neurons were ameliorated, while deterioration in behavioural performances was significantly enhanced. Thus, the intranasal approach enriched cell delivery to the brain, optimizing its therapeutic potential through its efficacious delivery and protection against dopaminergic neuron degeneration.

Genotype-dependent sex differentiation of dopaminergic neurons in primary cultures of embryonic mouse brain

1996 ◽  
Vol 93 (1-2) ◽  
pp. 136-142 ◽  
Author(s):  
Rosana Sibug ◽  
Eva Küppers ◽  
Cordian Beyer ◽  
Stephen C. Maxson ◽  
Christof Pilgrim ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Dopaminergic Neurons ◽  
Sex Differentiation ◽  
Primary Cultures ◽  
Embryonic Mouse

scholarly journals Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease

2020 ◽  
Author(s):  
Aditi Verma ◽  
Priya Suresh ◽  
Barathan Gnanabharathi ◽  
Etienne C. Hirsch ◽  
Vijayalakshmi Ravindranath
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Vesicle Recycling ◽  
Expression Of Genes ◽  
Dopamine Biosynthesis ◽  
Mptp Treatment ◽  
Development And Differentiation ◽  
Acute And Chronic Exposure

AbstractWe performed transcriptome analysis using RNA sequencing on substantia nigra pars compacta (SNpc) from mice after acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and Parkinson’s disease (PD) patients. Acute and chronic exposure to MPTP resulted in decreased expression of genes involved in sodium channel regulation. However, upregulation of pro-inflammatory pathways was seen after single dose but not after chronic MPTP treatment. Dopamine biosynthesis and synaptic vesicle recycling pathways were downregulated in PD patients and after chronic MPTP treatment in mice. Genes essential for midbrain development and determination of dopaminergic phenotype such as, LMX1B, FOXA1, RSPO2, KLHL1, EBF3, PITX3, RGS4, ALDH1A1, RET, FOXA2, EN1, DLK1, GFRA1, LMX1A, NR4A2, GAP43, SNCA, PBX1, and GRB10 were downregulated in human PD and overexpression of LMX1B rescued MPP+ induced death in SH-SY5Y neurons. Downregulation of gene ensemble involved in development and differentiation of dopaminergic neurons indicate their critical involvement in pathogenesis and progression of human PD.

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