Heat Shock Protein translocation induced by membrane fluidization increases tumor-cell sensitivity to chemotherapeutic drugs

2010 ◽  
Vol 296 (2) ◽  
pp. 257-267 ◽  
Author(s):  
Nina C. Dempsey ◽  
H. Elyse Ireland ◽  
Carly M. Smith ◽  
Christine F. Hoyle ◽  
John H.H. Williams
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Protein Translocation ◽  
Chemotherapeutic Drugs ◽  
Cell Sensitivity ◽  
Membrane Fluidization

scholarly journals Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters

2021 ◽  
Vol 14 (2) ◽  
pp. 107
Author(s):  
Nikola Pastvova ◽  
Petr Dolezel ◽  
Petr Mlejnek
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Cell Lines ◽  
Single Agent ◽  
Heat Shock Protein 90 ◽  
Genetic Alterations ◽  
Tumor Cell Lines ◽  
Cytotoxic Effects ◽  
Glioma Tumor

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and has a poor prognosis. Complex genetic alterations and the protective effect of the blood–brain barrier (BBB) have so far hampered effective treatment. Here, we investigated the cytotoxic effects of heat shock protein 90 (HSP90) inhibitors, geldanamycin (GDN) and 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin), in a panel of glioma tumor cell lines with various genetic alterations. We also assessed the ability of the main drug transporters, ABCB1 and ABCG2, to efflux GDN and 17-AAG. We found that GDN and 17-AAG induced extensive cell death with the morphological and biochemical hallmarks of apoptosis in all studied glioma cell lines at sub-micro-molar and nanomolar concentrations. Moderate efflux efficacy of GDN and 17-AAG mediated by ABCB1 was observed. There was an insignificant and low efflux efficacy of GDN and 17-AAG mediated by ABCG2. Conclusion: GDN and 17-AAG, in particular, exhibited strong proapoptotic effects in glioma tumor cell lines irrespective of genetic alterations. GDN and 17-AAG appeared to be weak substrates of ABCB1 and ABCG2. Therefore, the BBB would compromise their cytotoxic effects only partially. We hypothesize that GBM patients may benefit from 17-AAG either as a single agent or in combination with other drugs.

scholarly journals STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1

2005 ◽  
Vol 96 (2) ◽  
pp. 116-119 ◽  
Author(s):  
Hajime Nakatani ◽  
Michiya Kobayashi ◽  
Toufeng Jin ◽  
Takahiro Taguchi ◽  
Takeki Sugimoto ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Gastrointestinal Stromal Tumor ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Heat Shock Protein 90 ◽  
Stromal Tumor

scholarly journals Heat shock protein translocation and expression response is attenuated in response to repeated eccentric exercise

2009 ◽  
Vol 196 (3) ◽  
pp. 283-293 ◽  
Author(s):  
K. Vissing ◽  
M. L. Bayer ◽  
K. Overgaard ◽  
P. Schjerling ◽  
T. Raastad
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Eccentric Exercise ◽  
Protein Translocation ◽  
Expression Response

scholarly journals Role of Acetylation and Extracellular Location of Heat Shock Protein 90α in Tumor Cell Invasion

2008 ◽  
Vol 68 (12) ◽  
pp. 4833-4842 ◽  
Author(s):  
Yonghua Yang ◽  
Rehka Rao ◽  
Jie Shen ◽  
Yun Tang ◽  
Warren Fiskus ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Extracellular Location

Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity

2002 ◽  
Vol 84 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Xiaohong Chen ◽  
Qun Tao ◽  
Hai Yu ◽  
Lihuang Zhang ◽  
Xuetao Cao
Keyword(s):  
Heat Shock ◽  
Cell Membrane ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Heat Shock Protein 70 ◽  
Antitumor Immunity ◽  
Tumor Cell Membrane ◽  
Membrane Bound

Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator

2013 ◽  
Vol 10 (10) ◽  
pp. 3882-3891 ◽  
Author(s):  
Danielle Park ◽  
Bang-Wen Xie ◽  
Ermond R. Van Beek ◽  
Vicky Blankevoort ◽  
Ivo Que ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Optical Imaging ◽  
Heat Shock Protein 90 ◽  
Tumor Cell Death
Sign in / Sign up

Export Citation Format

Share Document