scholarly journals Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats

2019 ◽  
Vol 308 ◽  
pp. 45-50 ◽  
Author(s):  
Luísa Mota da Silva ◽  
Bruno César Pezzini ◽  
Lincon Bordignon Somensi ◽  
Luísa Nathália Bolda Mariano ◽  
Mariha Mariott ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Healing Process ◽  
Flavanone Glycoside

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Samuel Babafemi Olaleye
Keyword(s):  
Acetic Acid ◽  
Untreated Control ◽  
Wistar Rats ◽  
Low Dose ◽  
Healing Process ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Haematological Changes ◽  
Therapeutic Properties ◽  
Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

scholarly journals Ulcer Protective and Ulcer Healing Activities of Aqueous and Methanolic Extracts of Leaves of Rumex Bequaertii De Wild (Polygonaceae) in Rats

2015 ◽  
Vol 6 (2) ◽  
pp. 61
Author(s):  
Gilbert Ateufack ◽  
Breuil R. Dongmo Feudjio ◽  
William Nana Yousseu ◽  
Albert D. Atsamo ◽  
Albert Kamanyi
Keyword(s):  
Acetic Acid ◽  
Significant Variation ◽  
Healing Process ◽  
Negative Control ◽  
Chronic Ulcer ◽  
Male Rats ◽  
Control Group ◽  
Traditional Use ◽  
Mucus Production ◽  
Methanolic Extracts

The aqueous and methanolic extracts of Rumex bequaertii leaves were investigated for their ability to prevent and treated ulceration of the gastric mucosa in animal models.For this, adult male rats three to four months old and weighing on average 180 g were used for both tests. The extracts were tested orally at doses of 125, 250 and 500 mg/kg, on ulcerations experimentally induced by HCl/ethanol and pylorus ligation (acute ulcer) and acetic acid (chronic ulcer).These extracts showed protective and healing properties on ulcer induced models. A dose of 500 mg/kg of the two extracts inhibited ulceration induced by HCl/ethanol by 98.86 and 91.59 % respectively. With pyloric ligation, no significant variation of the volume of gastric juices, pH and gastric acidity was observed compared to the negative control rats. The aqueous extract alone at different doses presented a significant reduction of the ulceration surface resulting from chronic ulcer induced with acetic acid compared to the negative control group that received distilled water. For all three models of gastric ulcer induction used, the mass of mucus significantly increased in the groups that received the extracts. There was no significant variation in plasmatic nitric oxide (NO) concentrationand gastric supernatant of rats treated with both extracts compared to both control groups. These results reveal that the healing process of the extracts is not achieved through the NO pathway. This process could be due to increase in mucus production and thus supports its traditional use of the plant

scholarly journals Effects of Pfaffia glomerata (Spreng) pedersen aqueous extract on healing acetic acid-induced ulcers

2008 ◽  
Vol 51 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Cristina Setim Freitas ◽  
Cristiane Hatsuko Baggio ◽  
Samanta Luiza Araújo ◽  
Maria Consuelo Andrade Marques
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Healing Process ◽  
Intraperitoneal Administration ◽  
Oral Route ◽  
Chronic Gastric Ulcer ◽  
Pfaffia Glomerata ◽  
Tissue Healing

The present study was carried out to evaluate the acute toxicity and the effect of the aqueous extract of the roots from Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) (AEP) on the prevention of acetic acid-induced ulcer and on the healing process of previously induced ulcers. The acute toxicity was evaluated in Swiss mice after oral administration of a single dose and the chronic gastric ulcer was induced with local application of acetic acid. The results showed that the LD50 of the extract was 684.6 mg.kg-1 for the intraperitoneal administration and higher than 10 mg.kg-1by the oral route. The administration of the AEP did not prevent ulcers formation. However, the AEP increased of the healing process of previously induced ulcers. The results suggest that AEP chronically administered promote an increase of tissue healing, after the damage induced by acetic acid and the extract seemed to be destituted of toxic effects in the mice by the oral route.

Healing Process of Experimental Esophageal Ulcers Induced by Acetic Acid in Rats

1989 ◽  
Vol 24 (sup162) ◽  
pp. 6-10 ◽  
Author(s):  
H. Tsuji ◽  
Y. Fuse ◽  
K. Kawamoto ◽  
H. Fujino ◽  
T. Kodama
Keyword(s):  
Acetic Acid ◽  
Healing Process ◽  
Esophageal Ulcers

Roles of Muscularis Mucosae and Myofibroblasts in the Healing Process of Acetic Acid-Induced Ulcer

1990 ◽  
Vol 12 ◽  
pp. S39-S47 ◽  
Author(s):  
Masahiko Nakamura ◽  
Masaya Oda ◽  
Jun Inoue ◽  
Yasuhiro Nishizaki ◽  
Masaharu Tsuchiya
Keyword(s):  
Acetic Acid ◽  
Healing Process ◽  
Muscularis Mucosae

scholarly journals Healing process of acetic acid-induced gastric ulcer and gastric mucosal prostaglandin E generation level in rats.

1989 ◽  
Vol 50 (3) ◽  
pp. 366-368 ◽  
Author(s):  
Masayuki UCHIDA ◽  
Osamu KAWANO ◽  
Noriyuki MISAKI ◽  
Osamu IRINO
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Healing Process ◽  
Prostaglandin E ◽  
Generation Level

scholarly journals Effect of Allicin for Re-epithelialization During Healing in Oral Ulcer Model

2015 ◽  
Vol 1 (2) ◽  
pp. 87
Author(s):  
Renny Ayu Novianty ◽  
Bernadetta Esty Chrismawaty ◽  
Goeno Subagyo
Keyword(s):  
Acetic Acid ◽  
Buccal Mucosa ◽  
Healing Process ◽  
Alternative Therapy ◽  
Oral Ulcer ◽  
Garlic Extract ◽  
Aphthous Ulcer ◽  
Tissue Samples ◽  
Ulcer Model ◽  
Main Component

Allicin (diallyl thiosulfinate) is the main component of fresh garlic with multi-bioactivities as therapeutic agent. Recently, allicin is being proposed as alternative therapy for aphthous ulcer. The purpose of this study was to determine the effect of topical allicin in aqueous garlic extract on re-epithelialization during healing of acetic acid induced oral ulcer model. Thirty males SD rats aged 2 months were equally divided into two groups as experimental and control groups. After sedated with 0.2 ml intramuscular Ketamine injection, ulcer model was made by applying 99.5% glacial acetic acid-moistened paper disc on rat buccal mucosa. This would gene- rate an immediate necrotic tissue, which produced a single crateriform ulcer in each of the experimental rats for the next two days.  In the experimental group, one drop of allicin was applied twice daily onto the lesion. Three rats in each group were sacrificed on days 2, 3, 6, 9 and 12 after induction and were recorded as H0, H1, H4,H7 dan H10 groups, respectively. The tissue samples from buccal mucosa were processed for HematoxylinEosin (HE) staining, and then evaluated histologically. Re-epithelialization was assessed by measuring the thickness of the epithelium using an ocular micrometer under a light microscope. Data were analyzed statistically by Independent t-test with significant p-values of <0.05 (95%). Based on histological findings and trend graphs, it can be concluded that the topical application of allicin can accelerate re-epithelialization of ulcer healing process. This study suggests that allicin in aqueous garlic extract could be developed as therapeuticagent for aphthous ulcer

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