Investigation of the relaxing effect of a camphor nanoemulsion on rat isolated trachea

2021 ◽  
Vol 348 ◽  
pp. 109656
Author(s):  
Maíra M. Freitas ◽  
Pedro M. Cavalcante ◽  
Luiz A.M.S. Duarte-Filho ◽  
Cicero A.F. Macedo ◽  
Mariana C. Brito ◽  
...  
Keyword(s):  
Isolated Trachea ◽  
Relaxing Effect

The relaxing effect of SCH 23390 in the molluscan smooth muscle

1989 ◽  
Vol 94 (1) ◽  
pp. 341-344
Author(s):  
Hajime Murakami ◽  
Masakazu Sano ◽  
Takashi Tsukimura ◽  
Akira Yamazaki
Keyword(s):  
Smooth Muscle ◽  
Sch 23390 ◽  
Molluscan Smooth Muscle ◽  
Relaxing Effect

scholarly journals Effects of epithelium on antigen-induced histamine release from guinea-pig isolated trachea

1990 ◽  
Vol 52 ◽  
pp. 306
Author(s):  
Katsuyoshi Sugizaki ◽  
Tomokazu Hosokawa ◽  
Yutaka Kasuya
Keyword(s):  
Guinea Pig ◽  
Histamine Release ◽  
Isolated Trachea

scholarly journals Modified method for bronchial suture by Ramirez Gama compared to separate stitches suture: experimental study

2014 ◽  
Vol 41 (3) ◽  
pp. 188-192
Author(s):  
Vitor Mayer de Moura ◽  
Erinaldo Rocha Paes Lamdim ◽  
Felipe Souza Ferraz ◽  
Rodrigo Carvalho Turatti ◽  
Carolina de Barros Jaqueta ◽  
...  
Keyword(s):  
Experimental Study ◽  
The Other ◽  
Compressed Air ◽  
Air Leak ◽  
Bronchial Stump ◽  
Modified Method ◽  
Tracheal Pressure ◽  
Air Ventilation ◽  
Manual Suture ◽  
Isolated Trachea

OBJECTIVE: To experimentally compare two classic techniques described for manual suture of the bronchial stump. METHODS: We used organs of pigs, with isolated trachea and lungs, preserved by refrigeration. We dissected 30 bronchi, which were divided into three groups of ten bronchi each, of 3mm, 5mm, and 7mm, respectively. In each, we performed the suture with simple, separated, extramucosal stitches in five other bronchi, and the technique proposed by Ramirez and modified by Santos et al in the other five. Once the sutures were finished, the anastomoses were tested using compressed air ventilation, applying an endotracheal pressure of 20mmHg. RESULTS: the Ramirez Gama suture was more effective in the bronchi of 3, 5 and 7 mm, and there was no air leak even after subjecting them to a tracheal pressure of 20mmHg. The simple interrupted sutures were less effective, with extravasation in six of the 15 tested bronchi, especially in the angles of the sutures. These figures were not significant (p = 0.08). CONCLUSION: manual sutures of the bronchial stumps were more effective when the modified Ramirez Gama suture was used in the caliber bronchi arms when tested with increased endotracheal pressure.

scholarly journals MAG-EPA reduces severity of DSS-induced colitis in rats

2016 ◽  
Vol 310 (10) ◽  
pp. G808-G821 ◽  
Author(s):  
Caroline Morin ◽  
Pierre U. Blier ◽  
Samuel Fortin
Keyword(s):  
Therapeutic Potential ◽  
Combined Treatment ◽  
Neutrophil Infiltration ◽  
Antagonistic Effect ◽  
Omega 3 ◽  
Strong Activity ◽  
Tnf Α ◽  
Biochemical Analyses ◽  
Relaxing Effect

Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the intestinal mucosa of the large bowel. Omega-3 (ω3) fatty acid supplementation has been associated with a decreased production of inflammatory cytokines involved in UC pathogenesis. The aim of this study was to determine the preventive and therapeutic potential of eicosapentaenoic acid monoglyceride (MAG-EPA) in an in vivo rats model of UC induced by dextran sulfate sodium (DSS). DSS rats were untreated or treated per os with MAG-EPA. Morphological, histological, and biochemical analyses were performed following MAG-EPA administrations. Morphological and histological analyses revealed that MAG-EPA pretreatment (12 days pre-DSS) and treatment (6 days post-DSS) exhibited strong activity in reducing severity of disease in DSS rats. Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 were markedly lower compared with rats treated only with DSS. MAG-EPA per os administration decrease neutrophil infiltration in colon tissues, as depicted by myelohyperoxidase activity. Results also revealed a reduced activation of NF-κB pathways correlated with a decreased expression of COX-2 in colon homogenates derived from MAG-EPA-pretreated and treated rats. Tension measurements performed on colon tissues revealed that contractile responses to methacholine and relaxing effect induced by sodium nitroprusside were largely increased following MAG-EPA treatment. The combined treatment of MAG-EPA and vitamin E displayed an antagonistic effect on anti-inflammatory properties of MAG-EPA in DSS rats.

scholarly journals Aromatherapy Versus Pharmaceutical Interventions for Dementia Related Behaviors Translating & Integrating Scholarship Practicum

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Side Effects ◽  
Psychotropic Drugs ◽  
Elderly Population ◽  
The Elderly ◽  
Safe Alternative ◽  
Pharmaceutical Management ◽  
Diagnosis Of Dementia ◽  
Number Of Individuals ◽  
Relaxing Effect ◽  
Pharmaceutical Interventions

The elderly population is expected to double in the next thirty years increasing the number of individuals with the diagnosis of dementia. By proxy, dementia related behaviors such as agitation, anxiety and restless will also increase. Currently, pharmaceutical management of these behaviors include Ativan, Haldol and other psychotropic drugs which have side effects that place individuals at risk for falls and at times even aggravate the behaviors. Although, not widely researched, aromatherapy is a safe alternative to treating Dementia related behaviors. Research shows aromatherapy has a calming and relaxing effect which can be measured physiologically.

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