Prognostic value of combined preoperative fibrinogen-albumin ratio and platelet-lymphocyte ratio score in patients with breast cancer: A prognostic nomogram study

2020 ◽  
Vol 506 ◽  
pp. 110-121 ◽  
Author(s):  
Yufen Zheng ◽  
Chunlong Wu ◽  
Haixi Yan ◽  
Shiyong Chen
Keyword(s):  
Breast Cancer ◽  
Prognostic Value ◽  
Ratio Score ◽  
Albumin Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

scholarly journals Relationship between platelet-lymphocyte ratio and tumour infiltrating lymphocyte on metastatic in breast cancer patient

2019 ◽  
Vol 7 (6) ◽  
pp. 2045
Author(s):  
Indro Wibowo Sejati ◽  
Ida Bagus Tjakra Wibawa Manuaba ◽  
Putu Anda Tusta ◽  
Gede Budhi Setiawan
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Cancer Metastasis ◽  
Breast Cancer Subtype ◽  
Metastatic Breast ◽  
Breast Cancer Patients ◽  
Sample Group ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

Background: Platelet-lymphocyte ratio (PLR) is known associated with the prognosis of distant metastatic breast cancer. Tumor-infiltrating lymphocyte (TIL) in breast cancer also associated with the prognosis of distant metastatic breast cancer. In this study, we will examine the relationship between PLR and TIL, in association with the metastatic incidence in breast cancer.Methods: This research is a retrospective, analytic, cross-sectional study. Data was taken from medical records of breast cancer patients at Sanglah general hospital. Samples were taken by nested sampling by selecting all breast cancer patients from the period of January 1st, 2017, to December 31st, 2018, which had complete medical record data, with total sample 211. The PLR and TIL were calculated and analyzed in relation to metastasis incidence of breast cancer.Results: The sample characteristics were sorted by age, education, occupation, the area of origin, menstrual status, breast cancer staging, breast cancer subtype, TIL levels, lymphovascular invasion (LVI) status, metastatic status, and breast cancer grading. The data were analyzed to know the association of PLR, TIL, confounding factors in relation to metastatic incidences. In the sample group with PLR ≥ 156 10µ /µL, there were 22.9% cases of metastases (p = 0.002). The sample group at low TIL had metastatic event 12.5% with (p=0.442).Conclusions: PLR was associated with higher metastasis in breast cancer patients and low TIL had no association with breast cancer metastasis.

scholarly journals Efficacy of Postoperative FOLFOX Versus XELOX Chemotherapy for Gastric Cancer and Prognostic Value of Platelet–Lymphocyte Ratio in Patients Receiving XELOX

2020 ◽  
Vol 10 ◽  
Author(s):  
Xin Yin ◽  
Tianyi Fang ◽  
Yimin Wang ◽  
Chunfeng Li ◽  
Yufei Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Size ◽  
Prognostic Value ◽  
Cox Regression ◽  
Postoperative Chemotherapy ◽  
Chinese Patients ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Ptnm Stage

BackgroundSurgery combined with postoperative chemotherapy is an effective method for treating patients with gastric cancer (GC) in Asia. The important roles of systemic inflammatory response in chemotherapy have been gradually verified. The purpose of this study was to assess the difference in clinical effectiveness of FOLFOX (oxaliplatin + leucovorin + 5-fluorouracil) and XELOX (oxaliplatin + capecitabine), and the prognostic value of postoperative platelet–lymphocyte ratio (PLR) in the XELOX group.MethodsPatients who received radical gastrectomy combined with postoperative chemotherapy between 2004 and 2014 were consecutively selected into the FOLFOX and XELOX groups. Group bias was reduced through propensity score matching, which resulted in 278 patients in each group. Cut-off values of systemic immune inflammation (SII) score and PLR were obtained by receiver operating characteristic curve. Kaplan–Meier and Log-rank tests were used to analyze overall survival. The chi-square test was used to analyze the association between clinical characteristics and inflammatory indexes. Univariate and multivariate analyses based on Cox regression analysis showed independent risk factors for prognosis. The nomogram was made by R studio.ResultsPatients receiving XELOX postoperative chemotherapy had better survival than those receiving FOLFOX (P < 0.001), especially for stage III GC (P = 0.002). Preoperative SII was an independent risk factor for prognosis in the FOLFOX group, and PLR of the second postoperative chemotherapy regimen in the XELOX group, combined with tumor size and pTNM stage, could construct a nomogram for evaluating recurrence and prognosis.ConclusionXELOX is better than FOLFOX for treatment of GC in Chinese patients, and a nomogram constructed by PLR, tumor size and pTNM stage can predict recurrence and prognosis.

scholarly journals Platelet Lymphocyte Ratio (PLR) Related with Clinicopathological Characteristics of Balinese Women Breast Cancer Patient

2019 ◽  
Vol 30 ◽  
pp. vi144
Author(s):  
Sinta Wiranata ◽  
Putu Anda Tusta Adiputra ◽  
Anak Agung Wiradewi Lestari ◽  
I Putu Yuda Prabawa ◽  
I Gde Putu Supadmanaba
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Clinicopathological Characteristics ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

scholarly journals The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

2021 ◽  
Vol 92 (1) ◽  
pp. 16-23
Author(s):  
Konrad Piotr Muzykiewicz ◽  
Ewa Iwanska ◽  
Maja Janeczek ◽  
Izabela Glanowska ◽  
Kaziemierz Karolewski ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

scholarly journals Preoperative Serum Platelet-Lymphocyte Ratio as a Prognostic Factor in Cholangiocarcinoma Patients after Radical Resection: A Retrospective Analysis of 119 Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Ying Wu ◽  
Danyang Zhou ◽  
Guoping Zhang ◽  
Fengming Yi ◽  
Long Feng
Keyword(s):  
Prognostic Factor ◽  
Adjuvant Therapy ◽  
Prognostic Value ◽  
Surgical Margin ◽  
Progression Free Survival ◽  
Radical Resection ◽  
Positive Surgical Margin ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Preoperative Serum

Aims. Although prognostic markers are important to establish therapeutic strategies in patients for conducting radical resection of cholangiocarcinoma (CCA), there is still a lack of simple, valid, and repeatable markers in clinical settings. We aim to evaluate the prognostic value of the preoperative serum platelet-lymphocyte ratio (PLR) in CCA patients who underwent radical resection. Methods. We retrospectively analyzed CCA patients who underwent radical resection surgery in our institution from January 2011 to June 2016. Baseline PLR and other clinical pathological data were measured when patients were diagnosed initially. The prognostic value of PLR in overall survival (OS) and progression-free survival (PFS) were analyzed with the Cox proportional hazard model and the Kaplan–Meier method. Results. This study retrospectively analyzed 119 patients who underwent radical resection of CCA. During a median follow-up time of 11.0 months, there were 99.2% recurrences and 42.9% who died, and the median OS and PFS were 9.4 months and 7.4 months, respectively. Multivariate Cox analysis identified that elevated levels of PLR (PLR>157.25) as a significant factor predicted poorer OS (P=0.018, HR: 2.160, 95% CI: 1.139-4.096) and PFS (P=0.005, HR: 1.930, 95% CI: 1.220-3.053). In subgroup analysis, PLR also effectively predicted OS (P=0.016, HR: 2.515, 95% CI: 1.143-5.532) and PFS (P=0.042, HR: 1.908, 95% CI: 0.982-3.713) in CCA patients with positive lymphatic metastasis and/or positive surgical margin who required adjuvant therapy. Conclusions. The preoperative serum PLR is an independent prognostic factor for OS and PFS in CCA patients after radical resection, including patients requiring adjuvant therapy.

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