scholarly journals Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Cancer Cell ◽  
2017 ◽  
Vol 32 (2) ◽  
pp. 155-168.e6 ◽  
Author(s):  
Marco Mina ◽  
Franck Raynaud ◽  
Daniele Tavernari ◽  
Elena Battistello ◽  
Stephanie Sungalee ◽  
...  
Keyword(s):  
Cancer Evolution ◽  
Genomic Alterations ◽  
Conditional Selection ◽  
Selection Of

scholarly journals Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2001 ◽  
Author(s):  
Reetu Mukherji ◽  
John Marshall ◽  
Andreas Seeber
Keyword(s):  
Colorectal Cancer ◽  
Current Knowledge ◽  
Locally Advanced ◽  
Tumor Resection ◽  
Daily Routine ◽  
Precision Oncology ◽  
Genomic Alterations ◽  
Future Challenges ◽  
The Status ◽  
Selection Of

The selection of treatment according to genomic alterations is a standard approach in metastatic colorectal cancer but is only starting to have an impact in the earlier stages of the disease. The status of genes like KRAS, BRAF, and MMR has substantial survival implications, and concerted research efforts have revolutionized treatment towards precision oncology. In contrast, a genomic-based approach has not changed the adjuvant setting after curative tumor-resection in the daily routine so far. This review focuses on the current knowledge regarding prognostic and predictive genomic biomarkers in patients with locally advanced nonmetastasized colorectal cancer. Furthermore, we provide an outlook on future challenges for a personalized adjuvant treatment approach in patients with colorectal cancer.

scholarly journals Pervasive Conditional Selection of Driver Mutations and Modular Epistasis Networks in Cancer

2022 ◽  
Author(s):  
Jaime Iranzo ◽  
George Gruenhagen ◽  
Jorge Calle-Espinosa ◽  
Eugene Koonin
Keyword(s):  
Driver Mutations ◽  
Conditional Selection ◽  
Selection Of

scholarly journals Conditional Selection of B Cells in Mice With an Inducible B Cell Development

2018 ◽  
Vol 9 ◽  
Author(s):  
Elias Hobeika ◽  
Marcel Dautzenberg ◽  
Ella Levit-Zerdoun ◽  
Roberta Pelanda ◽  
Michael Reth
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Development ◽  
B Cell Development ◽  
Conditional Selection ◽  
Selection Of

Tumor Evolutionary Principles: How Intratumor Heterogeneity Influences Cancer Treatment and Outcome

2016 ◽  
pp. e141-e149 ◽  
Author(s):  
Subramanian Venkatesan ◽  
Charles Swanton
Keyword(s):  
Drug Resistance ◽  
Clinical Trials ◽  
Advanced Disease ◽  
Phylogenetic Reconstruction ◽  
Cancer Therapeutics ◽  
Therapeutic Strategies ◽  
Intratumor Heterogeneity ◽  
Cancer Evolution ◽  
Generation Sequencing ◽  
Selection Of

Recent studies have shown that intratumor heterogeneity contributes to drug resistance in advanced disease. Intratumor heterogeneity may foster the selection of a resistant subclone, sometimes detectable prior to treatment. Next-generation sequencing is enabling the phylogenetic reconstruction of a cancer's life history and has revealed different modes of cancer evolution. These studies have shown that cancer evolution is not always stochastic and has certain constraints. Consideration of cancer evolution may enable the better design of clinical trials and cancer therapeutics. In this review, we summarize the different modes of cancer evolution and how this might impact clinical outcomes. Furthermore, we will discuss several therapeutic strategies for managing emergent intratumor heterogeneity.

scholarly journals THE MERGER AND DEVELOPMENT OF EQUIVALENCE CLASSES BY UNREINFORCED CONDITIONAL SELECTION OF COMPARISON STIMULI

1988 ◽  
Vol 50 (2) ◽  
pp. 145-162 ◽  
Author(s):  
Richard R. Saunders ◽  
Kathryn J. Saunders ◽  
Kimberly C. Kirby ◽  
Joseph E. Spradlin
Keyword(s):  
Equivalence Classes ◽  
Conditional Selection ◽  
Selection Of

Selection of Less-Prevalent Overgrowth Syndromes

2019 ◽  
pp. 19-38
Author(s):  
Roger E. Stevenson ◽  
Bryan D. Hall
Keyword(s):  
Case Report ◽  
Environmental Influences ◽  
Maternal Diabetes ◽  
Fetal Life ◽  
Genomic Alterations ◽  
Causative Gene ◽  
Increased Risk ◽  
Genomic Disorders ◽  
Overgrowth Syndromes ◽  
Selection Of

In addition to the major generalized overgrowth syndromes described in this text, there is a rich case report literature on less common and less well-defined disorders in which overgrowth has been noted. The latter disorders are described concisely in this chapter. In some cases there have been multiple cases reported and the causative gene or genomic alterations have been identified. Although others are suspected to be genetic or genomic disorders, no specific cause has been implicated. These disorders are sufficiently uncommon that a body of literature has not accumulated and the manifestations are sufficiently variable that most are not clinically recognized. In addition, the chapter takes note of those environmental influences that can produce overgrowth. Maternal diabetes is the most common of the environmental influences that cause overgrowth during fetal life and carries a several-fold increased risk of malformations.

Cognitive gadgets and cognitive priors

2019 ◽  
Vol 42 ◽  
Author(s):  
Gian Domenico Iannetti ◽  
Giorgio Vallortigara
Keyword(s):  
Cognitive Neuroscience ◽  
Selection Of

Abstract Some of the foundations of Heyes’ radical reasoning seem to be based on a fractional selection of available evidence. Using an ethological perspective, we argue against Heyes’ rapid dismissal of innate cognitive instincts. Heyes’ use of fMRI studies of literacy to claim that culture assembles pieces of mental technology seems an example of incorrect reverse inferences and overlap theories pervasive in cognitive neuroscience.

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