scholarly journals Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

Cell ◽  
2008 ◽  
Vol 135 (6) ◽  
pp. 1053-1064 ◽  
Author(s):  
Sarah De Val ◽  
Neil C. Chi ◽  
Stryder M. Meadows ◽  
Simon Minovitsky ◽  
Joshua P. Anderson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Combinatorial Regulation ◽  
Forkhead Transcription Factors ◽  
Endothelial Gene Expression

Regulation of angiogenesis by ETS transcription factors

2009 ◽  
Vol 37 (6) ◽  
pp. 1248-1253 ◽  
Author(s):  
Anna M. Randi ◽  
Andrea Sperone ◽  
Nicola H. Dryden ◽  
Graeme M. Birdsey
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Gene Transcription ◽  
Target Genes ◽  
Ets Transcription Factors ◽  
Ets Family ◽  
Endothelial Gene Expression ◽  
Ets Factors

Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.

scholarly journals Hierarchical Interactions of Homeodomain and Forkhead Transcription Factors in Regulating Odontogenic Gene Expression

2011 ◽  
Vol 286 (24) ◽  
pp. 21372-21383 ◽  
Author(s):  
Shankar R. Venugopalan ◽  
Xiao Li ◽  
Melanie A. Amen ◽  
Sergio Florez ◽  
Diana Gutierrez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Forkhead Transcription Factors

scholarly journals FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

2003 ◽  
Vol 162 (4) ◽  
pp. 613-622 ◽  
Author(s):  
Jonathan Gilley ◽  
Paul J. Coffer ◽  
Jonathan Ham
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Binding Sites ◽  
Sympathetic Neurons ◽  
Dependent Manner ◽  
Promoter Activation ◽  
Forkhead Transcription Factors ◽  
Forkhead Box ◽  
Foxo Transcription Factors

Developing sympathetic neurons die by apoptosis when deprived of NGF. BIM, a BH3-only member of the BCL-2 family, is induced after NGF withdrawal in these cells and contributes to NGF withdrawal–induced death. Here, we have investigated the involvement of the Forkhead box, class O (FOXO) subfamily of Forkhead transcription factors in the regulation of BIM expression by NGF. We find that overexpression of FOXO transcription factors induces BIM expression and promotes death of sympathetic neurons in a BIM-dependent manner. In addition, we find that FKHRL1 (FOXO3a) directly activates the bim promoter via two conserved FOXO binding sites and that mutation of these sites abolishes bim promoter activation after NGF withdrawal. Finally, we show that FOXO activity contributes to the NGF deprivation–induced death of sympathetic neurons.

Gene expression of forkhead transcription factors in the normal and diseased human prostate

2009 ◽  
Vol 103 (11) ◽  
pp. 1574-1580 ◽  
Author(s):  
Leonie van der Heul-Nieuwenhuijsen ◽  
Natasja F. Dits ◽  
Guido Jenster
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Human Prostate ◽  
Forkhead Transcription Factors

scholarly journals Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors

Development ◽  
2012 ◽  
Vol 139 (8) ◽  
pp. 1457-1466 ◽  
Author(s):  
X. Zhu ◽  
S. M. Ahmad ◽  
A. Aboukhalil ◽  
B. W. Busser ◽  
Y. Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Differential Regulation ◽  
Cell Type ◽  
Drosophila Cell ◽  
Forkhead Transcription Factors ◽  
Cell Type Specific

scholarly journals Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors

2008 ◽  
Vol 121 (1) ◽  
pp. 38-47 ◽  
Author(s):  
K. Papadopoulou ◽  
S. S. Ng ◽  
H. Ohkura ◽  
M. Geymonat ◽  
S. G. Sedgwick ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Fission Yeast ◽  
Regulation Of Gene Expression ◽  
G1 Phase ◽  
Forkhead Transcription Factors

scholarly journals Cell cycle regulated transcription: from yeast to cancer

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 877 ◽  
Author(s):  
Christopher J. McInerny
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Cell Division ◽  
Model Systems ◽  
Gene Products ◽  
Control Of Gene Expression ◽  
Forkhead Transcription Factors ◽  
Fundamental Process

Recent studies have revealed exciting new functions for forkhead transcription factors in cell proliferation and development. Cell proliferation is a fundamental process controlled by multiple overlapping mechanisms, and the control of gene expression plays a major role in the orderly and timely division of cells. This occurs through transcription factors regulating the expression of groups of genes at particular phases of the cell division cycle. In this way, the encoded gene products are present when they are required. This review outlines recent advances in our understanding of this process in yeast model systems and describes how this knowledge has informed analysis in more developmentally complex eukaryotes, particularly where it is relevant to human disease.

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