scholarly journals Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models

Cell Reports ◽  
2021 ◽  
Vol 37 (4) ◽  
pp. 109886
Author(s):  
Jiali Dong ◽  
Yuan Li ◽  
Huiwen Xiao ◽  
Shuqin Zhang ◽  
Bin Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Models ◽  
Oral Microbiota

Repurposing [11C]MC1 for PET Imaging of Cyclooxygenase-2 in Colorectal Cancer Xenograft Mouse Models

2021 ◽  
Author(s):  
Amanda J. Boyle ◽  
Andrea Narvaez ◽  
Junchao Tong ◽  
Sami S. Zoghbi ◽  
Victor W. Pike ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Models ◽  
Pet Imaging ◽  
Cyclooxygenase 2

The path to metastatic mouse models of colorectal cancer

Oncogene ◽  
2018 ◽  
Vol 37 (19) ◽  
pp. 2481-2489 ◽  
Author(s):  
Gabriele Romano ◽  
Sharmeen Chagani ◽  
Lawrence N. Kwong
Keyword(s):  
Colorectal Cancer ◽  
Mouse Models

scholarly journals Mouse models of colorectal cancer

2011 ◽  
pp. 450-462 ◽  
Author(s):  
Yunguang Tong ◽  
Wancai Yang ◽  
H. Phillip Koeffler
Keyword(s):  
Colorectal Cancer ◽  
Mouse Models

scholarly journals Mouse Models of Colorectal Cancer-Derived Circulating Tumor Cells

2016 ◽  
Vol 6 (7) ◽  
Author(s):  
Lahiri Kanth Nanduri ◽  
Sebastian Garcia
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Mouse Models

scholarly journals The mechanism of the premetastatic niche facilitating colorectal cancer liver metastasis generated from myeloid-derived suppressor cells induced by the S1PR1–STAT3 signaling pathway

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Qi Lin ◽  
Li Ren ◽  
Mi Jian ◽  
Pingping Xu ◽  
Jun Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
T Cell ◽  
Liver Metastasis ◽  
Signaling Pathway ◽  
Mouse Models ◽  
Poor Prognosis ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Premetastatic Niche

Abstract The tumor-derived factors involved in the expansion and accumulation of myeloid-derived suppressor cells (MDSCs) in metastatic dissemination of colorectal cancer (CRC) to the liver has not been studied. Immunohistochemistry was used to detect sphingosine-1-phosphate receptor 1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) in human colorectal tumors. IL-6 and interferon-γ were detected by enzyme-linked immunosorbent assay (ELISA). Tumor growth, invasion, and migration were evaluated by MTT, transwell, and wound healing assays, respectively. Subcutaneous tumor-bearing and CRC liver metastasis (CRLM) nude mouse models were constructed. The percentage of MDSCs was measured using multicolor flow cytometry. Western blot assay was used to evaluate S1PR1 and p-STAT3 expression in MDSCs after separation from the liver and tumor by magnetic antibody. T-cell suppression assay was detected by carboxyfluorescein succinimidyl ester (CFSE). Aberrant co-expressed S1PR1 and p-STAT3 was correlated with metachronous liver metastasis and poor prognosis in CRC. A mutual activation loop between S1PR1 and STAT3 can enhance CRC cell proliferation, migration, and invasion in vitro and in vivo. The expression of p-STAT3 and its downstream proteins can be regulated by S1PR1. p-STAT3 was the dependent signaling pathway of S1PR1 in the promotion of cell growth and liver metastasis in CRC. The level of IL-6 and the associated MDSCs stimulated by the S1PR1–STAT3 correlated with the number of liver metastatic nodes in the CRLM mouse models and patients. Increased CD14+HLA-DR−/low MDSCs from CRLM patients inhibited autologous T-cell proliferation and predict poor prognosis. The S1PR1–STAT3–IL-6–MDSCs axis operates in both tumor cells and MDSCs involved in the promotion of growth and liver metastasis in CRC. MDSCs induced by S1PR1–STAT3 in CRC cells formed the premetastatic niche in the liver can promote organ-specific metastasis.

scholarly journals Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

2014 ◽  
Vol 307 (3) ◽  
pp. G249-G259 ◽  
Author(s):  
James C. Fleet
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mouse Models ◽  
Human Colon ◽  
Low Grade ◽  
Preclinical Models ◽  
Dietary Interventions ◽  
Single Model ◽  
Human Colon Cancer ◽  
Molecular Etiology

Colorectal cancer is a heterogeneous disease that is one of the major causes of cancer death in the U.S. There is evidence that lifestyle factors like diet can modulate the course of this disease. Demonstrating the benefit and mechanism of action of dietary interventions against colon cancer will require studies in preclinical models. Many mouse models have been developed to study colon cancer but no single model can reflect all types of colon cancer in terms of molecular etiology. In addition, many models develop only low-grade cancers and are confounded by development of the disease outside of the colon. This review will discuss how mice can be used to model human colon cancer and it will describe a variety of new mouse models that develop colon-restricted cancer as well as more advanced phenotypes for studies of late-state disease.

Abstract 2356: Characterization of molecular signatures predicting response to 5-FU based chemotherapy in mouse models of colorectal cancer

2014 ◽  
Author(s):  
Jamie N. Hadac ◽  
Terrah J. Paul Olson ◽  
Alyssa A. Leystra ◽  
Dawn M. Albrecht ◽  
Linda Clipson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Models ◽  
Molecular Signatures
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