Faculty Opinions recommendation of The oral microbiota in colorectal cancer is distinctive and predictive.

The study of intestinal and oral microflora and their metabolites playing an important role in intestinal homeostasis, has led to the identification of species closely related to the development of colorectal cancer, intracellular correlations of fungi and bacteria compared to control. The correlation between oral microbiota and intestinal microflora, as well as associated with the mucous membrane of the large intestine, was revealed. It was noted that the use of eu- and probiotics improved the immunological indices and the structure of the intestinal microbiota. Thus, studying the oral and intestinal microbiota and its metabolites may prove to be a simple, accessible and informative method for the early diagnosis of colon cancer. However, most studies indicate only changes in the quantitative and qualitative composition of the microbiota, hardly revealing its cause-effect relations with the processes of tumor formation in the colon. Therefore, it is necessary to continue studies of this problem.

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Metabolic and Community Synergy of Oral Bacteria in Colorectal Cancer

mSphere ◽

10.1128/msphere.00102-16 ◽

2016 ◽

Vol 1 (3) ◽

Cited By ~ 62

Author(s):

Kaitlin J. Flynn ◽

Nielson T. Baxter ◽

Patrick D. Schloss

Keyword(s):

Colorectal Cancer ◽

Fusobacterium Nucleatum ◽

Oral Bacteria ◽

Oral Microbiota ◽

Community Members ◽

Content Type ◽

Bacterial Physiology ◽

Oral Biofilms ◽

Two Factors

ABSTRACT The oral periodontopathic bacterium Fusobacterium nucleatum has been repeatedly associated with colorectal tumors. Molecular analysis has identified specific virulence factors that promote tumorigenesis in the colon. However, other oral community members, such as members of the Porphyromonas spp., are also found with F. nucleatum on colonic tumors, and thus, narrow studies of individual pathogens do not take community-wide virulence properties into account. A broader view of oral bacterial physiology and pathogenesis identifies two factors that could promote colonization and persistence of oral bacterial communities in the colon. The polymicrobial nature of oral biofilms and the asaccharolytic metabolism of many of these species make them well suited to life in the microenvironment of colonic lesions. Consideration of these two factors offers a novel perspective on the role of oral microbiota in the initiation, development, and treatment of colorectal cancer.

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Human oral microbiome dysbiosis as a novel tool for detecting noninvasive biomarkers for colorectal cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.3_suppl.23 ◽

2021 ◽

Vol 39 (3_suppl) ◽

pp. 23-23

Author(s):

Cheng Kong

Keyword(s):

Colorectal Cancer ◽

Colorectal Tumor ◽

Oral Microbiome ◽

Colorectal Carcinogenesis ◽

Oral Microbiota ◽

Healthy Controls ◽

Microbial Composition ◽

Potential Association ◽

Tumor Association ◽

Noninvasive Biomarkers

23 Background: The oral microbiome may play an important role in colorectal carcinogenesis. However, few studies have investigated the association between oral microbiome and the development of colorectal cancer (CRC). We aimed to investigate whether oral health–colorectal tumor association has an underlying microbial basis, in the quest for novel non-invasive biomarkers for CRC. Methods: We collected oral swab samples from 161 patients with CRC, 34 patients with colorectal adenoma (CRA), and 58 healthy volunteers. The oral microbiota was assessed using 16S rRNA sequencing. The oral microbiome was characterized, microbial markers were identified, and colorectal tumor (CRA and CRC) classifiers were constructed and validated. Results: Oral microbial composition and diversity were significantly different among the three groups; the CRA group had the highest diversity. Analysis of the functional potential of oral microbiota demonstrated that the pathway involving cell motility was overrepresented in the CRA and CRC groups relative to that in the healthy controls. Moreover, a random forest model was constructed based on oral microbial markers, which could distinguish the colorectal tumor groups from the healthy controls and achieve a powerful classification potential in the discovery and validation cohorts. Conclusions: This study suggests a potential association between oral microbiome dysbiosis and colorectal cancer. Oral microbiota-based biomarkers may be helpful in predicting the risk of developing CRA and CRC.

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A Snapshot of Oral Microbiota in Patients with Colorectal Cancer

Eurasian Journal of Medical Investigation ◽

10.14744/ejmi.2021.34738 ◽

2021 ◽

Author(s):

Deniz Can Guven

Keyword(s):

Colorectal Cancer ◽

Oral Microbiota

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The oral microbiota in colorectal cancer is distinctive and predictive

Gut ◽

10.1136/gutjnl-2017-314814 ◽

2017 ◽

Vol 67 (8) ◽

pp. 1454-1463 ◽

Cited By ~ 119

Author(s):

Burkhardt Flemer ◽

Ryan D Warren ◽

Maurice P Barrett ◽

Katryna Cisek ◽

Anubhav Das ◽

...

Keyword(s):

Colorectal Cancer ◽

Protective Role ◽

Oral Bacteria ◽

Colorectal Polyps ◽

Oral Microbiome ◽

Classification Model ◽

Oral Microbiota ◽

Oral Swab ◽

Core Networks ◽

Colonic Tumours

Background and aimsMicrobiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC.MethodsWe profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103).ResultsSeveral oral taxa were differentially abundant in CRC compared with controls, for example, Streptococcus and Prevotellas pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% (CRC)/88% (polyps). We detected similar bacterial networks in colonic microbiota and oral microbiota datasets comprising putative oral biofilm forming bacteria. While these taxa were more abundant in CRC, core networks between pathogenic, CRC-associated oral bacteria such as Peptostreptococcus, Parvimonas and Fusobacterium were also detected in healthy controls. High abundance of Lachnospiraceae was negatively associated with the colonisation of colonic tissue with oral-like bacterial networks suggesting a protective role for certain microbiota types against CRC, possibly by conferring colonisation resistance to CRC-associated oral taxa and possibly mediated through habitual diet.ConclusionThe heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC.

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