Enhancement of pyroelectric catalysis of ferroelectric BaTiO3 crystal: The action mechanism of electric poling

2020 ◽  
Vol 46 (10) ◽  
pp. 16763-16769 ◽  
Author(s):  
Lin Chen ◽  
Huamei Li ◽  
Zheng Wu ◽  
Liangliang Feng ◽  
Shigang Yu ◽  
...  
Keyword(s):  
Action Mechanism ◽  
Batio3 Crystal

Tribological Performance and Action Mechanism of Cadmium Dialkyldithiophosphate

2005 ◽  
Vol 48 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Hu Jianqiang ◽  
Wei Xianyong ◽  
Yao Junbing ◽  
Xie Feng ◽  
Zhu Huanqin ◽  
...  
Keyword(s):  
Tribological Performance ◽  
Action Mechanism

The Action Mechanism of the Purified Platelet Aggregation Principle of Trimeresurus mucrosquamatus Venom

1979 ◽  
Vol 41 (03) ◽  
pp. 475-490 ◽  
Author(s):  
Chaoho Ouyang ◽  
Che-Ming Teng
Keyword(s):  
Platelet Aggregation ◽  
Adenine Nucleotides ◽  
Muscle Relaxants ◽  
Prostaglandin Synthesis ◽  
Action Mechanism ◽  
Crude Venom ◽  
Platelet Factor ◽  
Induce Platelet Aggregation ◽  
Minimal Concentration ◽  
Aggregation Principle

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

2018 ◽  
Vol 18 (15) ◽  
pp. 1275-1286 ◽  
Author(s):  
Luiz Felipe Domingues Passero ◽  
Lucas Antal Cruz ◽  
Gabriela Santos-Gomes ◽  
Eliana Rodrigues ◽  
Márcia Dalastra Laurenti ◽  
...  
Keyword(s):  
Side Effects ◽  
Visceral Leishmaniasis ◽  
Traditional Knowledge ◽  
Conventional Therapy ◽  
Pathogenic Species ◽  
Action Mechanism ◽  
In Vivo Assays ◽  
Clinical Forms

Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in most cases, are considered outdated. In addition, patients under classical treatment show serious side effects during drug administration, moreover parasites are able to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary to develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis. The present review will focus on the efficacy, side effects and action mechanism of classic drugs used in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a rational search toward the discovery and characterization of new and effective molecules (in vivo assays) from plants to be used against leishmaniasis.

Action mechanism of a novel herbicide, pyroxasulfone

2009 ◽  
Vol 95 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Yoshitaka Tanetani ◽  
Koichiro Kaku ◽  
Kiyoshi Kawai ◽  
Tomonori Fujioka ◽  
Tsutomu Shimizu
Keyword(s):  
Action Mechanism

Computational study of the binding mode, action mechanism and potency of pregabalin through molecular docking and quantum mechanical descriptors

2021 ◽  
Vol 1199 ◽  
pp. 113200
Author(s):  
Lorena Meneses ◽  
Sebastian Cuesta Hoyos ◽  
Guillermo Salgado Morán ◽  
Patricio Muñoz C. ◽  
Lorena Gerli Candia ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Computational Study ◽  
Binding Mode ◽  
Quantum Mechanical ◽  
Action Mechanism

scholarly journals Action mechanism of Escherichia coli DNA photolyase. II. Role of the chromophores in catalysis.

1987 ◽  
Vol 262 (1) ◽  
pp. 486-491 ◽  
Author(s):  
M S Jorns ◽  
E T Baldwin ◽  
G B Sancar ◽  
A Sancar
Keyword(s):  
Escherichia Coli ◽  
Action Mechanism ◽  
Dna Photolyase

scholarly journals Immunomodulatory Activities of Carica papaya L. Leaf Juice in a Non-Lethal, Symptomatic Dengue Mouse Model

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 501
Author(s):  
Mohd Ridzuan Mohd Abd Razak ◽  
Nor Azrina Norahmad ◽  
Nur Hana Md Jelas ◽  
Adlin Afzan ◽  
Norazlan Mohmad Misnan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Carica Papaya ◽  
Viral Rna ◽  
Action Mechanism ◽  
Dengue Virus Infection ◽  
Gm Csf ◽  
Intracellular Cytokines ◽  
Freeze Dried ◽  
Leaf Juice

The role of Carica papaya L. leaf juice in immune dysregulation caused by dengue virus infection remains unclear. This study aimed to investigate the immunomodulatory activities of the freeze-dried C. papaya leaf juice (FCPLJ) on AG129 mice infected with a clinical DENV-2 (DMOF015) isolate. The infected AG129 mice were orally treated with 500 and 1000 mg/kg/day of FCPLJ, for three days. Platelet, leukocyte, lymphocyte and neutrophil counts were microscopically determined. The level of plasma proinflammatory cytokines was measured by multiplex immunoassay. The levels of intracellular cytokines and viral RNA were determined by RT-qPCR technique. The results showed that the FCPLJ treatment increased the total white blood cell and neutrophil counts in the infected mice. The FCPLJ treatment decreased the level of GM-CSF, GRO-alpha, IL-1 beta, IL-6, MCP-1 and MIP-1 beta in the plasma of the infected mice. The intracellular IL-6 and viral RNA levels in the liver of infected mice were decreased by the FCPLJ treatment. In conclusion, this study supports the potential immunomodulatory role of the FCPLJ in a non-lethal, symptomatic dengue mouse model. Further studies on the action mechanism of the C. papaya leaf juice and its possible use as adjunctive dengue immunotherapy are warranted.

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