Mass transfer kinetics on the heterogeneous binding sites of molecularly imprinted polymers

2005 ◽  
Vol 60 (20) ◽  
pp. 5425-5444 ◽  
Author(s):  
Hyunjung Kim ◽  
Krzysztof Kaczmarski ◽  
Georges Guiochon
Keyword(s):  
Mass Transfer ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Mass Transfer Kinetics

scholarly journals Molecular Recognition: Perspective and a New Approach

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2757
Author(s):  
W. Rudolf Seitz ◽  
Casey J. Grenier ◽  
John R. Csoros ◽  
Rongfang Yang ◽  
Tianyu Ren
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Binding Kinetics ◽  
Molecularly Imprinted ◽  
New Approach ◽  
Imprinted Polymers ◽  
High Affinity ◽  
Water Blocking ◽  
High Level

This perspective presents an overview of approaches to the preparation of molecular recognition agents for chemical sensing. These approaches include chemical synthesis, using catalysts from biological systems, partitioning, aptamers, antibodies and molecularly imprinted polymers. The latter three approaches are general in that they can be applied with a large number of analytes, both proteins and smaller molecules like drugs and hormones. Aptamers and antibodies bind analytes rapidly while molecularly imprinted polymers bind much more slowly. Most molecularly imprinted polymers, formed by polymerizing in the presence of a template, contain a high level of covalent crosslinker that causes the polymer to form a separate phase. This results in a material that is rigid with low affinity for analyte and slow binding kinetics. Our approach to templating is to use predominantly or exclusively noncovalent crosslinks. This results in soluble templated polymers that bind analyte rapidly with high affinity. The biggest challenge of this approach is that the chains are tangled when the templated polymer is dissolved in water, blocking access to binding sites.

scholarly journals Recent advances in green reagents for molecularly imprinted polymers

RSC Advances ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 311-327 ◽  
Author(s):  
Xi Wu ◽  
Jiajun Du ◽  
Mengyao Li ◽  
Lintao Wu ◽  
Chun Han ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recent Advances ◽  
Green Reagents

Molecularly imprinted polymers (MIPs) are tailor-made materials with special binding sites.

A new restricted access molecularly imprinted fiber for direct solid phase microextraction of benzodiazepines from plasma samples

The Analyst ◽  
2019 ◽  
Vol 144 (14) ◽  
pp. 4320-4330 ◽  
Author(s):  
Lailah Cristina de Carvalho Abrão ◽  
Eduardo Costa Figueiredo
Keyword(s):  
Sample Preparation ◽  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Solid Phase Microextraction ◽  
Solid Phase ◽  
Plasma Samples ◽  
Molecularly Imprinted ◽  
Restricted Access ◽  
Imprinted Polymers ◽  
Direct Solid

Restricted access molecularly imprinted polymers (RAMIPs) are hybrid materials that present selective binding sites for a template (or similar molecules), and an external hydrophilic layer that avoids the binding of proteins to the material, making them appropriate for the sample preparation of protein fluids.

scholarly journals Microsphere Polymers in Molecular Imprinting: Current and Future Perspectives

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3256
Author(s):  
Tirza Ecclesia Orowitz ◽  
Patria Pari Agnes Ago Ana Sombo ◽  
Driyanti Rahayu ◽  
Aliya Nur Hasanah
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Pickering Emulsion ◽  
Minimum Size ◽  
Future Perspectives ◽  
Polymer Microsphere ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Emulsion Polymerisation ◽  
Molecularly Imprinted Microspheres

Molecularly imprinted polymers (MIPs) are specific crosslinked polymers that exhibit binding sites for template molecules. MIPs have been developed in various application areas of biology and chemistry; however, MIPs have some problems, including an irregular material shape. In recent years, studies have been conducted to overcome this drawback, with the synthesis of uniform microsphere MIPs or molecularly imprinted microspheres (MIMs). The polymer microsphere is limited to a minimum size of 5 nm and a molecular weight of 10,000 Da. This review describes the methods used to produce MIMs, such as precipitation polymerisation, controlled/‘Living’ radical precipitation polymerisation (CRPP), Pickering emulsion polymerisation and suspension polymerisation. In addition, some green chemistry aspects and future perspectives will also be given.

Preparation of molecularly imprinted polymers for the recognition of proteins via the generation of peptide-fragment binding sites by semi-covalent imprinting and enzymatic digestion

The Analyst ◽  
2015 ◽  
Vol 140 (5) ◽  
pp. 1448-1452 ◽  
Author(s):  
Hironori Taguchi ◽  
Hirobumi Sunayama ◽  
Eri Takano ◽  
Yukiya Kitayama ◽  
Toshifumi Takeuchi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Binding Sites ◽  
Enzymatic Digestion ◽  
Peptide Fragment ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

An acryloyl protein was copolymerized with a crosslinker, followed by enzymatic digestion, yielding protein imprinted polymers bearing peptide-fragment binding sites.

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