Weight Loss and Abdominal Pain Caused by Pancreatic Squamous Cell Carcinoma

IntroductionSquamous cell carcinoma (SCC) of the gastrointestinal (GI) tract is an uncommon occurrence, as it usually involves the esophagus or anal canal. Approximately 90% of cases of rectal malignancy are adenocarcinoma and other rectal cancers include lymphoma (1.3%), carcinoid (0.4%), and sarcoma (0.3%). We are presenting a rare and unique case of patient with SCC of the rectum presenting with lower abdominal pain and significant weight loss.CaseA 52 year old female was admitted with a two month history of diffuse lower abdominal pain and hematochezia. The pain was constant and pressure like. The patient was a nonsmoker and nondrinker. Review of systems was pertinent for an unintentional weight loss of 10lbs. Physical examination revealed diffuse lower abdominal tenderness and a firm, irregular anterior rectal mass. She had no lymphadenopathy and her skin exam was normal. Laboratory results a normocytic anemia with a hemoglobin of 8.8 g/dl and a CEA of 1.35 ng/ml. Abdominal CT scan revealed a 7 cm irregular rectal mass with extra luminal compression to the rectosigmoid area, (figure 1). The mass did not extend from uterus and confirmed with transvaginal ultrasound. Patient underwent a flex sigmoidoscopy which revealed a lesion 5 cm from anal verge extending distally. There is a semi-circumferential narrowing occupying 7% of lumen and a dense layer of mass tissue with superficial friability of mucosa. Biopsy was taken from the mass, histology shows invasive moderately differentiated squamous cell carcinoma (figure 1).DiscussionSCC of the rectum has a very similar presentation to colon adenocarcinoma. Diagnoses can be established by proctoscopy/colonoscopy and more specifically, a biopsy to get a definitive histological analysis. The latter is a used to differentiate from SCC of the anus, which presents similarly. Immunohistochemistry has proved useful in characterizing lesions, especially when using cytokeratin stains. Pathogenesis is unclear due to its rarity; however one of the proposed mechanisms suggests that inflammation or infection results in squamous metaplasia from which carcinoma develops. Thus there is an association with HPV and various squamous cancers. In conclusion, SCC of rectum is a distinct entity and it is important to shed some light on this rare condition because it has different epidemiology, etiology, pathogenies and requires a different treatment approach than other colorectal carcinomas. Surgery is the primary treatment which consists of local excision versus radical resection and the need for adjuvant therapy.Abstract ID: 38 Figure 1

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CLINICOPATHOLOGIC FEATURES OF CERVICAL CANCER PATIENTS SEEN IN A COMPREHENSIVE CANCER CENTRE IN NORTH-WESTERN NIGERIA

Open Journal of Medical Research (ISSN: 2734-2093) ◽

10.52417/ojmr.v2i1.211 ◽

2021 ◽

Vol 2 (1) ◽

Author(s):

M. A. Usman ◽

S. A. Otene

Keyword(s):

Cervical Cancer ◽

Weight Loss ◽

Squamous Cell Carcinoma ◽

Abdominal Pain ◽

Cell Carcinoma ◽

Clinical Features ◽

Squamous Cell ◽

Vaginal Bleeding ◽

Lower Abdominal Pain ◽

North Western

The purpose of this study was to evaluate the socio-demographic and clinicopathological features of patients with cervical cancer seen in a comprehensive cancer center in North-western Nigeria. It was a six years retrospective study of patients with cervical cancer treated in the Department of Radiotherapy and Oncology, UDUTH, Sokoto. Data was obtained from the patients’ case notes using a semi-structured data extraction form. A total of 220 cases were reviewed for patients whose mean age was 49.9 years (SD ± 11.9); with the age range of 24-87 years. Results show that squamous cell carcinoma was the most common histological type seen in 182(82.7%) of the patients, followed by adenocarcinoma 22(10%) and clear cell carcinoma 9(4.1%). Vaginal bleeding 110(50%), foul-smelling vaginal discharge103 (46.8%), fatigue 67(30.5%), lower abdominal pain 65(20.5%) and weight loss 30(13.6%) were the commonest clinical features. 176(80%) patients presented late stages (IIB – IVB) of cervical cancer. Concluding, most of the women with cervical cancer presented with features of vaginal bleeding or foul-smelling vaginal discharge, weight loss, fatigue and lower abdominal pain, with commonest histological categorization being squamous cell carcinoma. Late presentation of the disease was obviously observed in most of the cases diagnosed. The clinical features of cervical cancer identified in the cases reviewed are indicators of advanced disease. Thus, it is imperative that advocacy for cervical cancer screening should be stepped up in order to ensure early detection and prevent the progression of the disease to advanced stages.

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Clinico-Pathological Findings and Spatial Distributions of Esophageal Cancer in Arsi Zone, Central Ethiopia

10.21203/rs.3.rs-78101/v1 ◽

2020 ◽

Author(s):

Haji Aman Deybasso ◽

Kedir Teji Roba ◽

Berhanu Nega ◽

Tefera Belachew

Keyword(s):

Weight Loss ◽

Squamous Cell Carcinoma ◽

Esophageal Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

Spatial Distributions ◽

Central Ethiopia ◽

Presenting Symptoms ◽

High Incidence ◽

Arsi Zone

Abstract Background: Arsi Zone is one of the esophageal cancer endemic areas and reported to have high incidence of esophageal cancer in Ethiopia. This study assessed clinico-pathological patterns and spatial distributions of esophageal cancer in Arsi Zone, Oromia, Central Ethiopia.Methods: A cross sectional study design was carried out by abstracting data from 403 patients` records that were treated from January 2015 to January 2019. Data were collected by using structured data collection form and Geographical Positioning System software. The collected data were summarized in the form of tables, figures, means and standard deviations. Statistical data analysis was done using SPSS software version 21.0 while geospatial analysis was conducted using the Arc-GIS 10.1 software.Results: The disease was prominent among individuals aged 50 to 59 years. The mean age of females and males was 52.2(SD+10.41) and 56.94(SD +12.27) years respectively. The vast majority (98.3%) of the cases had squamous cell carcinoma. Dysphagia with weight loss accounted for 87.6 percent of the presenting symptoms. The tumor was located at the lower thorax of 42.9% of the patients. Majority (62%) of the patients were from the eastern and north-eastern parts of the Arsi zone. Overwhelming majorities of the patients were from the Robe, Jaju, Disksis and Sude districts.Conclusion: Dysphagia with weight loss was the major symptom during first visit. Squamous cell carcinoma was the predominant histopathological type. Eastern and the northeastern parts of the Zone are the most affected regions. Future studies should focus on the determinants of EC and precise areas with high incidence by using prospective studies through the population and/or facility-based cancer registry systems

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Diffuse peritonitis caused by spontaneous perforation of pyometra: A case report and literature review

10.21203/rs.3.rs-151635/v1 ◽

2021 ◽

Author(s):

Hao Xu ◽

Yifan Zhuang ◽

Caiming Wang ◽

Yongjie Zhou ◽

Haofei Chen ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Abdominal Pain ◽

Early Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Uterine Cavity ◽

Uterine Perforation ◽

Diffuse Peritonitis ◽

Appropriate Treatment ◽

The Right

Abstract BackgroundUterine perforation is commonly caused by iatrogenic injuries, tumours, and traumas. Uterine perforation resulting from infection is less common, and such perforation rarely causes abdominal empyema and diffuse peritonitis. Infectious complications such as shock and multiple organ dysfunction are extremely dangerous and even life threatening. Correct early diagnosis and appropriate treatment can reduce the mortality of pyometra.Case presentationA 62-year-old woman presented to our hospital with persistent abdominal pain for 5 hours. The patient had undergone hysteroscopy six months ago, and a cystic space-occupying lesion of the uterus was found one month ago. Perfect the various examinations, consider the patient as acute diffuse peritonitis Perforation of the digestive tract? Uterine cavity infection. In the emergency department, laparoscopic exploration was performed. During the operation, it was diagnosed as pyometra and perforation of the right uterine fundus. Then, combined with a gynecologist, a hysterectomy with double appendages was performed. The operation went smoothly. The patient had paralytic intestinal obstruction after the operation. After active symptomatic treatment The patient recovered well and was discharged. Postoperative pathology results were as follows: 1. Moderately differentiated squamous cell carcinoma of the cervix (non-keratinizing type); 2. Metastatic squamous cell carcinoma of the right ovary; 3. Perforation of the fundus of the uterus, pyometra, and extensive purulent inflammation of the muscle wall .ConclusionsUterine perforation is a rare cause of acute abdomen. Clinicians often don't know enough about this, and they are prone to misdiagnosis and missed diagnosis. For elderly women with abdominal pain and peritonitis, the possibility of empyema perforation should be considered during diagnosis and treatment, and the examination should be improved to avoid misdiagnosis, because correct early diagnosis and appropriate treatment can reduce the mortality of empyema.

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Pelvic Pain and Weight Loss in a Female with Primary Squamous Cell Carcinoma of the Rectum.

Southern Medical Journal ◽

10.1097/00007611-200510001-00054 ◽

2005 ◽

Vol 98 (Supplement) ◽

pp. S23

Author(s):

Join Y. Luh ◽

Samuel J. Wang ◽

Melisa Boersma ◽

Russell Higgins ◽

Sridhar Beeram ◽

...

Keyword(s):

Weight Loss ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Pelvic Pain ◽

Squamous Cell ◽

Primary Squamous Cell Carcinoma ◽

Carcinoma Of The Rectum

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PROGNOSTIC FACTORS AND SURVIVAL ANALYSIS IN ESOPHAGEAL CARCINOMA

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/0102-6720201600030003 ◽

2016 ◽

Vol 29 (3) ◽

pp. 138-141 ◽

Cited By ~ 11

Author(s):

Francisco TUSTUMI ◽

Cintia Mayumi Sakurai KIMURA ◽

Flavio Roberto TAKEDA ◽

Rodrigo Hideki UEMA ◽

Rubens Antônio Aissar SALUM ◽

...

Keyword(s):

Overall Survival ◽

Weight Loss ◽

Squamous Cell Carcinoma ◽

Esophageal Cancer ◽

Prognostic Factors ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinical Stage ◽

Curative Intent ◽

Poor Differentiation

ABSTRACT Background: Despite recent advances in diagnosis and treatment, esophageal cancer still has high mortality. Prognostic factors associated with patient and with disease itself are multiple and poorly explored. Aim: Assess prognostic variables in esophageal cancer patients. Methods: Retrospective review of all patients with esophageal cancer in an oncology referral center. They were divided according to histological diagnosis (444 squamous cell carcinoma patients and 105 adenocarcinoma), and their demographic, pathological and clinical characteristics were analyzed and compared to clinical stage and overall survival. Results: No difference was noted between squamous cell carcinoma and esophageal adenocarcinoma overall survival curves. Squamous cell carcinoma presented 22.8% survival after five years against 20.2% for adenocarcinoma. When considering only patients treated with curative intent resection, after five years squamous cell carcinoma survival rate was 56.6 and adenocarcinoma, 58%. In patients with squamous cell carcinoma, poor differentiation histology and tumor size were associated with worse oncology stage, but this was not evidenced in adenocarcinoma. Conclusion: Weight loss (kg), BMI variation (kg/m²) and percentage of weight loss are factors that predict worse stage at diagnosis in the squamous cell carcinoma. In adenocarcinoma, these findings were not statistically significant.

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Alimentary squamous cell carcinoma in psittacines: 12 cases and review of the literature

Journal of Veterinary Diagnostic Investigation ◽

10.1177/10406387211021480 ◽

2021 ◽

pp. 104063872110214

Author(s):

Viviana Gonzalez-Astudillo ◽

Aslı Mete ◽

Mauricio A. Navarro ◽

Francisco A. Uzal ◽

Javier Asin

Keyword(s):

Weight Loss ◽

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Alimentary Tract ◽

Clinical Signs ◽

Review Of The Literature ◽

Pet Birds ◽

Nymphicus Hollandicus ◽

Species Variability

Squamous cell carcinoma (SCC), which is a neoplasm that usually arises from the integument, is reported uncommonly in pet birds. Only a few reports of SCCs in the alimentary tract of birds, including psittacines, have been published, and a detailed description of the pathology is not available in the literature. We present here 12 cases of alimentary SCC in psittacines. The average age of the birds was 22.2 y (range: 15–29 y), and affected species included 4 Amazon parrots ( Amazona sp.), 3 cockatiels ( Nymphicus hollandicus), 3 macaws ( Ara sp.), 1 conure ( Eupsittula sp.), and 1 Senegal parrot ( Poicephalus sp.). Frequent clinical complaints included regurgitation, dysphagia, dyspnea, lethargy, and/or weight loss. SCC primarily affected the oral cavity in 6 of 12 cases, the crop alone in 2 of 12 cases, the crop and esophagus in 1 of 12 cases, the proventriculus alone in 1 of 12 cases, and the crop, esophagus, and proventriculus in 2 of 12 cases. Histologically, alimentary SCCs were locally invasive and often resulted in mucosal ulceration. Although there were no metastases in any of our cases, poor clinical outcomes were frequent and associated most commonly with complete effacement of the alimentary segment and severe inflammation with opportunistic bacterial infection. Our review of the literature records commonly affected species, variability of gross presentations and clinical signs, plausible etiologies, and current diagnostic developments.

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