Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors

Cell Chemical Biology ◽

10.1016/j.chembiol.2019.06.004 ◽

2019 ◽

Vol 26 (9) ◽

pp. 1322-1331.e4 ◽

Author(s):

David Weigt ◽

Cynthia A. Parrish ◽

Julie A. Krueger ◽

Catherine A. Oleykowski ◽

Alan R. Rendina ◽

...

Keyword(s):

Fatty Acid Synthase ◽

Specific Fatty Acid ◽

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De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae

Metabolic Engineering Communications ◽

10.1016/j.mec.2019.e00111 ◽

2020 ◽

Vol 10 ◽

pp. e00111 ◽

Author(s):

Florian Wernig ◽

Eckhard Boles ◽

Mislav Oreb

Keyword(s):

Saccharomyces Cerevisiae ◽

Cytochrome P450 ◽

Chain Length ◽

Fatty Acid Synthase ◽

De Novo ◽

Specific Fatty Acid ◽

Medium Chain ◽

De Novo Biosynthesis ◽

Medium Chain Length

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Discovery of fatty acid synthase inhibitors and their biosynthetic pathways by a novel target-directed genome mining strategy

Planta Medica ◽

10.1055/s-0035-1556330 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

J Li ◽

X Tang ◽

JJ Zhang ◽

EC O'Neill ◽

SM Mantovani ◽

...

Keyword(s):

Fatty Acid Synthase ◽

Genome Mining ◽

Biosynthetic Pathways ◽

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Dietary whole and cracked linseed increases the proportion of oleic and α-linolenic acids in adipose tissues and decreases stearoyl-coenzyme A desaturase, acetyl-coenzyme A carboxylase, and fatty acid synthase gene expression in the longissimus thoracis muscle of Yanbian Yellow cattle

Journal of Animal Science ◽

10.2527/jas2016.1050 ◽

2017 ◽

Vol 95 (2) ◽

pp. 718

Author(s):

X. Z. Li ◽

C. G. Yan ◽

J. Yu ◽

Q. S. Gao ◽

S. H. Choi ◽

...

Keyword(s):

Gene Expression ◽

Fatty Acid Synthase ◽

Adipose Tissues ◽

Acetyl Coenzyme A ◽

Acetyl Coenzyme ◽

Yellow Cattle ◽

Acetyl Coenzyme A Carboxylase ◽

Fatty Acid Synthase Gene

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Faculty Opinions recommendation of Architecture of mammalian fatty acid synthase at 4.5 A resolution.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031581.367827 ◽

2006 ◽

Author(s):

Xiayang Qiu

Keyword(s):

Fatty Acid Synthase

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Faculty Opinions recommendation of Structure of fungal fatty acid synthase and implications for iterative substrate shuttling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1081786.534702 ◽

2007 ◽

Author(s):

Jon Thorson

Keyword(s):

Fatty Acid Synthase

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Faculty Opinions recommendation of Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264040.789502810 ◽

2012 ◽

Author(s):

Wendy Hanna-Rose ◽

Tracy Vrablik

Keyword(s):

Phospholipid Composition ◽

Membrane Dynamics ◽

Specific Fatty Acid ◽

C Elegans ◽

Metabolic Event

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Faculty Opinions recommendation of Discovery of a regulatory subunit of the yeast fatty acid synthase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737533239.793574066 ◽

2020 ◽

Author(s):

Barbara Imperiali ◽

Greg Dodge

Keyword(s):

Fatty Acid Synthase ◽

Regulatory Subunit

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Inhibitors of Fatty Acid Synthase for Prostate Cancer

10.21236/ada570535 ◽

2012 ◽

Author(s):

Steven J. Kridel

Keyword(s):

Prostate Cancer ◽

Fatty Acid Synthase

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Fatty Acid Synthase Activity as a Target for c-Met Driven Prostate Cancer

10.21236/ada582141 ◽

2013 ◽

Author(s):

David T. Coleman

Keyword(s):

Prostate Cancer ◽

Fatty Acid Synthase

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Inhibitors of Fatty Acid Synthase for Prostate Cancer. Revision

10.21236/ada603995 ◽

2013 ◽

Author(s):

Steven J. Kridel

Keyword(s):

Prostate Cancer ◽

Fatty Acid Synthase

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