Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort

Abstract Context and Objective Being born small or large for gestational age and intrauterine exposure to gestational diabetes (GDM) increase the risk of type 2 diabetes in the offspring. However, the potential combined deleterious effects of size at birth and GDM exposure remains unknown. We examined the independent effect of size at birth and the influence of GDM exposure in utero on cardiometabolic traits, body composition, and puberty status in children. Design, Participants, and Methods The present study was a longitudinal birth cohort study. We used clinical data from 490 offspring of mothers with GDM and 527 control offspring aged 9 to 16 years, born singleton at term from the Danish National Birth Cohort with available birthweight data. Results We found no evidence of a U-shaped association between size at birth (expressed as birthweight, sex, and gestational age adjusted z-score) and cardiometabolic traits. Body size in childhood and adolescence reflected the size at birth but was not reflected in any metabolic outcome. No synergistic adverse effect of being born small or large for gestational age and exposure to GDM was shown. However, GDM was associated with an adverse metabolic profile and earlier onset of female puberty in childhood and adolescence independently of size at birth. Conclusion In childhood and adolescence, we found GDM was a stronger predictor of dysmetabolic traits than size at birth. The combination of being born small or large and exposed to GDM does not exacerbate the metabolic profile in the offspring.

Download Full-text

Intergenerational determinants of offspring size at birth: a life course and graphical analysis using the Aberdeen Children of the 1950s Study (ACONF)

International Journal of Epidemiology ◽

10.1093/ije/dyu028 ◽

2014 ◽

Vol 43 (3) ◽

pp. 749-759 ◽

Cited By ~ 11

Author(s):

S. M. Morton ◽

B. L. De Stavola ◽

D. A. Leon

Keyword(s):

Life Course ◽

Graphical Analysis ◽

Offspring Size ◽

The 1950S ◽

Size At Birth

Download Full-text

The influence of maternal pregnancy glucose concentrations on associations between a fetal imprinted gene allele score and offspring size at birth

BMC Research Notes ◽

10.1186/s13104-018-3933-1 ◽

2018 ◽

Vol 11 (1) ◽

Author(s):

Clive J. Petry ◽

Ken K. Ong ◽

Ieuan A. Hughes ◽

Carlo L. Acerini ◽

David B. Dunger

Keyword(s):

Offspring Size ◽

Imprinted Gene ◽

Size At Birth

Download Full-text

Size at birth and height in early adolescence: a prospective birth cohort study

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2008000400018 ◽

2008 ◽

Vol 24 (4) ◽

pp. 871-878 ◽

Cited By ~ 3

Author(s):

Cora L. P. Araújo ◽

Pedro C. Hallal ◽

Gisele A. Nader ◽

Ana Maria B. Menezes ◽

Cesar G. Victora

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Early Adolescence ◽

Strong Predictor ◽

Birth Length ◽

Birth Cohort Study ◽

Size At Birth ◽

Prospective Birth Cohort ◽

Prospective Birth Cohort Study

The aim of this study was to evaluate the association between size at birth (birthweight and birth length) and height in early adolescence in a prospective birth cohort study in Pelotas, Rio Grande do Sul, Brazil. Interviews were carried out in 1993, including measurements of birthweight and length, and in 2004-2005, including measurements of weight and height. This analysis includes 4,452 individuals, with a mean age of 11.3 years (standard deviation - SD = 0.3), representing a follow-up rate of 87.5%. Mean height at 11 years was 145.8 cm (SD = 7.9), or 144.9 cm (SD = 7.7) in boys and 146.8 cm (SD = 7.9) in girls. Birthweight and birth length were positively associated with height in early adolescence in the crude analysis, but after adjustment for confounding and for each other, only the effect of birth length was still significant. A one z-score increase in birth length was associated with a 1.63 cm increase in height at 11 years. The present study shows that birth length is a strong predictor of later height, while the effect of birth weight disappears after adjustment for birth length.

Download Full-text

Pregnancy Serum DLK1 Concentrations are associated with Indices of Insulin Resistance and Secretion

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab123 ◽

2021 ◽

Author(s):

Clive J Petry ◽

Keith A Burling ◽

Peter Barker ◽

Ieuan A Hughes ◽

Ken K Ong ◽

...

Keyword(s):

Insulin Resistance ◽

Transmembrane Protein ◽

Protein A ◽

Maternal Serum ◽

Offspring Size ◽

Oral Glucose ◽

Insulinogenic Index ◽

Glucose Tolerance Tests ◽

Epidermal Growth ◽

Size At Birth

Abstract Context DLK1 (delta like non-canonical notch ligand 1) is a paternally-expressed imprinted gene that encodes an epidermal growth factor repeat-containing transmembrane protein. A bioactive, truncated DLK1 protein is present in the circulation, and has roles in development and metabolism. Objective We sought to investigate links between maternal pregnancy circulating DLK1 concentrations and: (1) maternal and fetal DLK1 genotypes, (2) maternal insulin resistance and secretion and (3) offspring size at birth. Patients, design and setting We measured third trimester maternal serum DLK1 concentrations and examined their associations with parentally-transmitted fetal and maternal DLK1 genotypes, indices of maternal insulin resistance and secretion derived from 75g oral glucose tolerance tests performed around week 28 of pregnancy, and offspring size at birth in 613 pregnancies from the Cambridge Baby Growth Study. Results Maternal DLK1 concentrations were associated with the paternally-transmitted fetal DLK1 rs12147008 allele (p=7.8x10 -3) but not with maternal rs12147008 genotype (p=0.4). Maternal DLK1 concentrations were positively associated with maternal pre-pregnancy BMI (p=3.5x10 6), and (after adjustment for maternal BMI) with both maternal fasting insulin resistance (HOMA IR: p=0.01) and measures of maternal insulin secretion in response to oral glucose (insulinogenic index: p=1.2x10 -3; insulin disposition index: p=0.049). Further positive associations were found with offspring weight (p=0.02) and head circumference at birth (p=0.04). Conclusion These results are consistent with a partial paternal or placental origin for the maternal circulating DLK1 which may lead to increased maternal circulating DLK1 concentrations, stimulation of maternal insulin resistance and compensatory hyperinsulinemia during pregnancy, and the promotion of fetal growth.

Download Full-text

Maternal predator‐exposure affects offspring size at birth but not telomere length in a live‐bearing fish

Ecology and Evolution ◽

10.1002/ece3.6035 ◽

2020 ◽

Vol 10 (4) ◽

pp. 2030-2039 ◽

Cited By ~ 3

Author(s):

Stefano Monteforte ◽

Silvia Cattelan ◽

Chiara Morosinotto ◽

Andrea Pilastro ◽

Alessandro Grapputo

Keyword(s):

Telomere Length ◽

Offspring Size ◽

Size At Birth

Download Full-text

P1-68 Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70: the Helsinki Birth Cohort Study

Early Human Development ◽

10.1016/s0378-3782(07)70238-4 ◽

2007 ◽

Vol 83 ◽

pp. S101

Author(s):

K. Feldt ◽

E. Kajantie ◽

K. Räikkönen ◽

D.I.W. Phillips ◽

C. Osmond ◽

...

Keyword(s):

Cohort Study ◽

Body Size ◽

Birth Cohort ◽

Psychosocial Stress ◽

Hypothalamic Pituitary Adrenal Axis ◽

Birth Cohort Study ◽

Hypothalamic Pituitary Adrenal ◽

Adrenal Axis ◽

Pituitary Adrenal Axis ◽

Size At Birth

Download Full-text

Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study

Nutrients ◽

10.3390/nu12113466 ◽

2020 ◽

Vol 12 (11) ◽

pp. 3466

Author(s):

Clive J. Petry ◽

Ken K. Ong ◽

Ieuan A. Hughes ◽

David B. Dunger

Keyword(s):

Glucose Tolerance ◽

Offspring Size ◽

Oral Glucose ◽

Micronutrient Supplementation ◽

Oral Glucose Tolerance ◽

Growth Study ◽

Positive Effects ◽

Increased Risk ◽

Multiple Micronutrient ◽

Size At Birth

Multiple micronutrient supplementation (MMS) in pregnancy has previously been associated with positive effects on fetal growth, but its value in high-income countries remains controversial. In this study, we investigated effects of pregnancy MMS on offspring size at birth and adiposity, along with risks of various maternal outcomes of pregnancy, using the prospective Cambridge Baby Growth Study. Maternal MMS was reported in 528 out of 970 women who completed pregnancy questionnaires. Gestational diabetes (GDM) was assessed using results from 75 g oral glucose tolerance tests at week 28 of pregnancy. Offspring size at birth was assessed using standard anthropometric measurements and adiposity using skinfold calipers. MMS was associated with increased risk of developing GDM (risk ratio = 1.86 (1.13–3.08), p = 0.02), as well as increased offspring size at birth in terms of weight (p = 0.03), head circumference (p = 0.04), and flank, and subscapular and triceps skinfold thicknesses (p = 0.04, 0.03, and 0.003, respectively). There was no association with quadriceps skinfold thickness (p = 0.2), suggesting that the increased adiposity was partially regionalized. In women who underwent oral glucose tolerance testing, nearly all of these associations were attenuated by adjusting for GDM. These results suggest that the increased offspring size at birth, including (regionalized) adiposity associated with pregnancy, and MMS may be partially related to the development of GDM.

Download Full-text