scholarly journals Assessment of Dechlorane Plus and related compounds in foodstuffs and estimates of daily intake from Lebanese population

Chemosphere ◽  
2019 ◽  
Vol 235 ◽  
pp. 492-497 ◽  
Author(s):  
Inas Abdel Malak ◽  
Ronan Cariou ◽  
Ingrid Guiffard ◽  
Anaïs Vénisseau ◽  
Gaud Dervilly-Pinel ◽  
...  
Foods ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 574 ◽  
Author(s):  
Nada Lebbos ◽  
Claude Daou ◽  
Rosette Ouaini ◽  
Hanna Chebib ◽  
Michel Afram ◽  
...  

The objective of this study was to assess Lebanese population exposure to trace elements (TEs) via white pita consumption. A survey of white pita consumption was achieved among one thousand Lebanese individuals, grouped into adults (above 15 years old, men, and women) and young people (6–9 and 10–14 years old). The most consumed pita brands, labeled B1, B2, and B3, were selected. Levels of TEs (i.e., As, Cd, Co, Cr, Hg, Ni, and Pb) in B1, B2, B3 pitas were measured. The highest contents of TEs in pitas were: Ni (1292 µg/kg) and Co (91 µg/kg) in B1; As (400 µg/kg) and Cd (< 15 µg/kg) in B2; Cr (363 µg/kg), Pb (260 µg/kg), and Hg (0.89 µg/kg) in B3. The pita brand B3 was the source of the highest TEs exposure, except for Ni for which it was B1. Daily exposures to TEs due to the fact of pita consumption were compared to safety levels. There were no safety concerns for Hg, Cd, Cr or Co (except the 95th percentile of 6–9 years old). An excess of the Ni tolerable daily intake was observed for the most exposed populations. The very low margins of exposure for As and Pb suggest a worrying risk for the Lebanese population.


2010 ◽  
Vol 44 (17) ◽  
pp. 6608-6613 ◽  
Author(s):  
De-Gao Wang ◽  
Meng Yang ◽  
Hong Qi ◽  
Ed Sverko ◽  
Wan-Li Ma ◽  
...  

Chemosphere ◽  
2018 ◽  
Vol 207 ◽  
pp. 413-420 ◽  
Author(s):  
Inas Abdel Malak ◽  
Ronan Cariou ◽  
Anaïs Vénisseau ◽  
Gaud Dervilly-Pinel ◽  
Farouk Jaber ◽  
...  

2012 ◽  
Vol 404 (9) ◽  
pp. 2625-2637 ◽  
Author(s):  
M. L. Feo ◽  
E. Barón ◽  
E. Eljarrat ◽  
D. Barceló

1998 ◽  
Vol 14 (1-2) ◽  
pp. 223-237 ◽  
Author(s):  
Risto Santti ◽  
Sari Mäkelä ◽  
Leena Strauss ◽  
Johanna Korkman ◽  
Marja-Lsa Kostian

Exposure to diethylstilbestrol (DES) induces persistent structural and functional alterations in the developing reproductive tract of males. It is possible that xenoestrogens other than DES alter sexual differentiation in males and account for the increasing incidence of developmental disorders of the reproductive tract in men and wild animals. Phytoestrogens (coumestans, isoflavonoids, flavonoids, and lignans) present in numerous edible plants are quantitatively the most important environmental estrogens when their hormonal potency is assessed in vitro. They exert their estrogenic activity by interacting with estrogen receptors (ERs) in vitro. They may also act as antiestrogens by competing for the binding sites of estrogen receptors or the active site of the estrogen biosynthesizing and metabolizing enzymes, such as aromatase and estrogen-specific 17β-hydroxysteroid oxidoreductase (type 1). In theory, phytoestrogens and structurally related compounds could harm the reproductive health of males also by acting as antiestrogens. There are very little data on effects of phytoestrogens in males. Estrogenic effects in wildlife have been described but the evidence for the role of phytoestrogens is indirect and seen under conditions of excessive exposure. In doses comparable to the daily intake from soy- based feed, isoflavonoids such as genistein were estrogen agonists in the prostate of adult laboratory rodents. When given neonatally, no persistent effects were observed. In contrast, the central nervous system (CNS)-gonadal axis and the male sexual behavior of the rat appear to be sensitive to phytoestrogens during development. The changes were similar but not identical to those seen after neonatal treatment with DES, but higher doses of phytoestrogens were needed.There are no data on effects of phytoestrogens given as pure compounds to humans, and all evidence currently available is indirect and based on experiments with phytoestrogen- rich diets. The hormonal effects have so far been marginal. It is known that the intake of phytoestrogens is higher in countries where the incidence rates of clinical conditions linked to estrogen exposure, such as hypospadia or testicular and prostatic cancers, are low. This makes it unlikely that phytoestrogens, or structurally related compounds in amounts present in Asian diets, would have DES-like actions. This does not exclude possibilities that they influence concentrations of endogenous sex hormones and interact with the ER, and that through these mechanisms they alter male sex differentiation, and consequently increase the risks of male genital tract tumors or developmental disorders, particularly in doses exceeding the daily intake of phytoestrogens in Asian diets.


2016 ◽  
Vol 26 (2) ◽  
pp. 53-59 ◽  
Author(s):  
Kotaro MINOMO ◽  
Kiyoshi NOJIRI ◽  
Mamoru MOTEGI ◽  
Nobutoshi OHTSUKA ◽  
Yuichi HORII

2011 ◽  
Vol 45 (12) ◽  
pp. 5088-5098 ◽  
Author(s):  
Ed Sverko ◽  
Gregg T. Tomy ◽  
Eric J. Reiner ◽  
Yi-Fan Li ◽  
Brian E. McCarry ◽  
...  

Author(s):  
Elisa Ghelli ◽  
Ronan Cariou ◽  
Gaud Dervilly ◽  
Giampiero Pagliuca ◽  
Teresa Gazzotti

Dechlorane Plus is a polychlorinated compound which has exclusively anthropic origin. This compound has been manufactured for close to 60 years for various applications, but mainly as flame retardant. Dechlorane Plus and other Dechlorane-related compounds (DRCs) are currently marketed as a replacement for Dechlorane, also known as Mirex, banned in 1978. These compounds share comparable properties to persistent organic pollutants (POPs), such as persistence in the environment, high lipophilicity, bioaccumulation through the food web and adverse effects on the environment and human health. Despite their long production history, they have been only recently reported in various environmental compartments, such as air, soil, and foodstuff. The aim of this review is to provide a picture of the current state of knowledge on worldwide DRC levels in food, in order to highlight gaps and research needs. The review compares the data on DRC contamination available in literature, considering different food categories and sampling country. In addition, it is specified whether the data were obtained from studies on foodstuff to estimate dietary intake, to evaluate the contamination near the e-waste treatment area or for environmental monitoring purposes.


2016 ◽  
Vol 88 ◽  
pp. 206-220 ◽  
Author(s):  
Pu Wang ◽  
Qinghua Zhang ◽  
Haidong Zhang ◽  
Thanh Wang ◽  
Huizhong Sun ◽  
...  

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