The prion fragment PrP106-127 adopts a secondary structure typical of aggregated fibrils in langmuir monolayers of brain lipid extract

2020 ◽  
Vol 230 ◽  
pp. 104930
Author(s):  
B. Sandrino ◽  
K. Jochelavicius ◽  
D. Volpati ◽  
S.C. Barbosa ◽  
T.M. Nobre ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Langmuir Monolayers ◽  
Lipid Extract ◽  
Brain Lipid

Intravenous Infusion of a Standardised Coagulation Active Phospholipid Complex in Uremic Coagulation Deficiency

1972 ◽  
Vol 27 (03) ◽  
pp. 554-558 ◽  
Author(s):  
K.l Schimpf ◽  
H.-W Hanf-Hoppe ◽  
H Immich
Keyword(s):  
Analysis Of Variance ◽  
Intravenous Infusion ◽  
Thrombin Generation ◽  
Lipid Extract ◽  
Brain Lipid ◽  
Phospholipid Complex ◽  
Control Subjects ◽  
Uremic Patients ◽  
Clinical Experiments

SummaryInfusion for 90 min of 10 ml brain lipid extract brought thrombin generation and prothrombin consumption levels in uremic patients to normal for 3 h. After quick injection of the same doses (within 3 min) the effect lasted less than l1/2h. Control subjects produced hypercoagulability with the same treatment. The results of these clinical experiments, obtained with 12 subjects, were shown by analysis of variance to be statistically significant.

Characterization of Tamm-Horsfall Urinary Glycoprotein

1973 ◽  
Vol 31 ◽  
pp. 420-421
Author(s):  
John P. Robinson ◽  
J. David Puett
Keyword(s):  
Electron Microscopy ◽  
Circular Dichroism ◽  
Secondary Structure ◽  
Quaternary Structure ◽  
Normal Adult ◽  
Morphological Properties ◽  
Adult Males ◽  
Circular Dichroïsm ◽  
Urinary Glycoprotein

Much work has been reported on the chemical, physical and morphological properties of urinary Tamm-Horsfall glycoprotein (THG). Although it was once reported that cystic fibrotic (CF) individuals had a defective THG, more recent data indicate that THG and CF-THG are similar if not identical.No studies on the conformational aspects have been reported on this glycoprotein using circular dichroism (CD). We examined the secondary structure of THG and derivatives under various conditions and have correlated these results with quaternary structure using electron microscopy.THG was prepared from normal adult males and CF-THG from a 16-year old CF female by the method of Tamm and Horsfall. CF female by the method of Tamm and Horsfall.

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