scholarly journals DETERMINING THE NEED FOR ADDITIONAL TESTING WITH QUANTIFERON TB GOLD IN PATIENTS WITH POSITIVE TUBERCULIN SKIN TEST AND HISTORY OF BCG VACCINATION

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A327
Author(s):  
Antony Arumairaj ◽  
Hansang Park ◽  
Fernando Quesada ◽  
Imnett Habtes
2004 ◽  
Vol 19 (10) ◽  
pp. 1039-1044 ◽  
Author(s):  
Hillary V. Kunins ◽  
Andrea A. Howard ◽  
Robert S. Klein ◽  
Julia H. Arnsten ◽  
Alain H. Litwin ◽  
...  

2007 ◽  
Vol 15 (1) ◽  
pp. 168-171 ◽  
Author(s):  
Jose Domínguez ◽  
Juan Ruiz-Manzano ◽  
Malú De Souza-Galvão ◽  
Irene Latorre ◽  
Celia Milà ◽  
...  

ABSTRACT We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.


2017 ◽  
Vol 145 (9) ◽  
pp. 1824-1833 ◽  
Author(s):  
E. AYUBI ◽  
A. DOOSTI-IRANI ◽  
A. SANJARI MOGHADDAM ◽  
S. KHAZAEI ◽  
K. MANSORI ◽  
...  

SUMMARYDiagnosis of latent tuberculosis infection (LTBI) is a concern in haemodialysis (HD) patients. Many studies have compared QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) for detecting LTBI and reported theκstatistic of agreement between QFT-GIT and TST in HD patients. The present study aimed to systematically review this literature and conduct meta-analysis of individual studies that estimated theκbetween QFT-GIT with TST among HD patients. All relevant published studies that were available as full-text were obtained by searching Medline (1950), Web of Sciences (1945), Scopus (1973) through May 2016. Theκwas re-estimated from the individual studies and pooled using random effect meta-analysis. Subgroup analysis and meta-regression were applied to evaluate the effect of Bacillus Calmette–Guérin (BCG) vaccination, TST cut-off points, quality of studies, sample size and age on variation ofκestimate. Eight studies involving 901 HD patients were included in meta-analysis. The pooledκestimate was 0·28 (I2= 18·4%,P= 0·239, 95% confidence intervals 0·22–0·34). The discordance of TST−/QFT-GIT+ was more than TST+/QFT-GIT−. History of BCG vaccination, TST cut-off points and age are related to variation ofκestimates. TST and QFT-GIT are not comparable in detecting LTBI in HD patients. The higher TST−/QFT-GIT+ ratio compared with TST+/QFT-GIT− ratio, may indicate the superiority of QFT-GIT over TST for detection LTBI in HD patients.


2008 ◽  
Vol 41 (4) ◽  
pp. 416-418 ◽  
Author(s):  
Florian H. Pilsczek ◽  
Stefan H.E. Kaufmann

Latent tuberculosis was studied in a research laboratory. A prevalence of positive tuberculin skin test results (> 15mm) of 20% was found and the main predictors were place of birth in a foreign country with high prevalence of tuberculosis and a history of contact with patients with untreated active tuberculosis.


Epidemiology ◽  
2020 ◽  
Vol 31 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Maryam B. Haddad ◽  
Timothy L. Lash ◽  
Andrew N. Hill ◽  
Thomas R. Navin ◽  
Kenneth G. Castro ◽  
...  

2002 ◽  
Vol 128 (1) ◽  
pp. 37-45 ◽  
Author(s):  
A. J. PLANT ◽  
R. E. WATKINS ◽  
B. GUSHULAK ◽  
T. O'ROURKE ◽  
W. JONES ◽  
...  

We investigated the prevalence and predictors of positive tuberculin skin test (TST) results among prospective Vietnamese migrants. We interviewed and medically screened 1395 Vietnamese people aged over 15 years who had applied to migrate to Australia. Approximately 44% of applicants had an induration of 10 mm or more, and 18·6% had an induration of 15 mm or more. A positive tuberculin skin test at 5 mm, 10 mm and 15 mm of induration cut-points was significantly associated with age (OR 1·01–1·02 per year) and duration of smoking (OR 1·03–1·12 per year). Smoking appears to be an important factor associated with increased susceptibility to mycobacterial infection. It is not yet clear whether the increased tuberculin reactivity associated with smoking reflects an increased risk of tuberculosis among these migrants.


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