Prevalence of Positive Tuberculin Skin Test (TST) Results among Pre-clinical and Clinical Medical Students during their Educational Course in Mashhad, Iran

2016 ◽  
Vol 14 (3) ◽  
pp. 1-5
Author(s):  
Fatemeh Habibi ◽  
Atefeh Hajipour
Keyword(s):  
Medical Students ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
Educational Course

scholarly journals Evaluation of Tuberculin Skin Test (TST) in Medical Students in Mazandaran University of Medical Sciences, Sari, Iran

2016 ◽  
Vol 9 (5) ◽  
pp. 274 ◽  
Author(s):  
Shahriar Alian ◽  
Amir Dadashi ◽  
Narges Najafi ◽  
Ahmad Alikhani ◽  
Alireza Davoudi ◽  
...  
Keyword(s):  
Medical Students ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Therapeutic Process ◽  
Positive Tuberculin Skin Test ◽  
Positive Test ◽  
Second Phase ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Occupational Risk Factor

<p><strong>BACKGROUND: </strong>Working in health care units has been known as occupational risk factor in mycobacterium tuberculosis (TB) infection. The TB exposure rate in medical students is more than other people. In several studies significant correlation has been reported between hospital presence hours and positive PPD test prevalence. With regard to morbidity of several medical students and nursing staff due to primary tuberculosis in recent years, we decided to investigate positive tuberculin skin test (TST) prevalence in medical students and examine correlation between positive cases prevalence with presence hours in hospitals.</p><p><strong>METHODS: </strong>This was a cross sectional study and 297 medical students of Mazandaran University of medical sciences were investigated. TST was done with Mantoux method. After 48 hours, injection site induration was measured. Subjects that had induration &lt;10 millimeters were injected again (1-3 weeks later) with same method. (As a booster dose)</p><p><strong>RESULTS: </strong>32 cases (10.7%) had positive test at the first phase. Second phase was done on rest 265 persons and 20 cases had positive test. In summation 52 positive cases (17.5%) were observed. 21 cases of 151 persons (13.9%) in group with &lt;100 hours/annual hospital presence, had positive tests. 21 cases of 71 persons (16.9%) in group with 100-1000 h/a hospital presence (Extern) and 19 cases of 75 people (25.3%) those who had  &gt;1000 h/a hospital presence(Intern),  had positive tests. There was a meaningful statically difference in positive tests, between groups &lt; 1000 hours exposure and the other who had &gt; 1000 hours contact (p=0.032).</p><p><strong>CONCLUSIONS: </strong>Because of, Interns’ high responsibilities and their more involvement in patient’s diagnostic and therapeutic process, they have high chance to contact with undiagnosed and diagnosed tuberculosis patients. Due to these reasons, TB infection rate is increasing among Interns. As a result of these findings, performing PPD test should be considered at the beginning of entrance to hospital departments and then annually. Necessary tasks and following up are needed to new positive cases.</p>

scholarly journals Validity of a self-reported history of a positive tuberculin skin test

2004 ◽  
Vol 19 (10) ◽  
pp. 1039-1044 ◽  
Author(s):  
Hillary V. Kunins ◽  
Andrea A. Howard ◽  
Robert S. Klein ◽  
Julia H. Arnsten ◽  
Alain H. Litwin ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
History Of

Robustness of NHANES Estimates of the US Prevalence of a Positive Tuberculin Skin Test

Epidemiology ◽  
2020 ◽  
Vol 31 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Maryam B. Haddad ◽  
Timothy L. Lash ◽  
Andrew N. Hill ◽  
Thomas R. Navin ◽  
Kenneth G. Castro ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
The Us

scholarly journals Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis

2007 ◽  
Vol 15 (1) ◽  
pp. 168-171 ◽  
Author(s):  
Jose Domínguez ◽  
Juan Ruiz-Manzano ◽  
Malú De Souza-Galvão ◽  
Irene Latorre ◽  
Celia Milà ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Mycobacterium Bovis ◽  
Latent Infection ◽  
Positive Tuberculin Skin Test ◽  
Gamma Interferon ◽  
Bcg Vaccination ◽  
Blood Tests

ABSTRACT We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

scholarly journals Predictors of tuberculin reactivity among prospective Vietnamese migrants: the effect of smoking

2002 ◽  
Vol 128 (1) ◽  
pp. 37-45 ◽  
Author(s):  
A. J. PLANT ◽  
R. E. WATKINS ◽  
B. GUSHULAK ◽  
T. O'ROURKE ◽  
W. JONES ◽  
...  
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Mycobacterial Infection ◽  
Positive Tuberculin Skin Test ◽  
Cut Points ◽  
Increased Risk ◽  
Increased Susceptibility

We investigated the prevalence and predictors of positive tuberculin skin test (TST) results among prospective Vietnamese migrants. We interviewed and medically screened 1395 Vietnamese people aged over 15 years who had applied to migrate to Australia. Approximately 44% of applicants had an induration of 10 mm or more, and 18·6% had an induration of 15 mm or more. A positive tuberculin skin test at 5 mm, 10 mm and 15 mm of induration cut-points was significantly associated with age (OR 1·01–1·02 per year) and duration of smoking (OR 1·03–1·12 per year). Smoking appears to be an important factor associated with increased susceptibility to mycobacterial infection. It is not yet clear whether the increased tuberculin reactivity associated with smoking reflects an increased risk of tuberculosis among these migrants.

scholarly journals Evaluation of Gamma Interferon Immune Response Elicited by the Newly Constructed PstS-1(285-374):CFP10 Fusion Protein To Detect Mycobacterium tuberculosis Infection

2014 ◽  
Vol 21 (4) ◽  
pp. 552-560 ◽  
Author(s):  
Leonardo Silva de Araujo ◽  
Fernanda Carvalho de Queiroz Mello ◽  
Nidai de Bárbara Moreira da Silva ◽  
Janaina Aparecida Medeiros Leung ◽  
Silvia Maria Almeida Machado ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Positive Tuberculin Skin Test ◽  
Gamma Interferon ◽  
Preventative Treatment ◽  
Mycobacterium Tuberculosis Infection ◽  
Content Type ◽  
Ifn Γ ◽  
First Time

ABSTRACTThe PstS1 antigen is highly immunogenic, principally when combined with CFP10 during both latent and active TB infection. In the present study, a selectedpstS1gene fragment was cloned, fused with CFP10, and expressed inEscherichia coli. The product [PstS-1(285-374):CFP10] was compared to the recombinant fused RD1 (region of deletion 1) protein (ESAT-6:CFP10) in detectingMycobacterium tuberculosisinfection in 108 recent contacts of pulmonary tuberculosis (TB) cases, considering a positive tuberculin skin test (TST) to be the baseline. The release of gamma interferon (IFN-γ) in 22-h whole-blood and 5-day lymphocyte stimulation assays primed with each antigen was determined. All contacts were clinically followed for up to 1 year, and 87% of the tuberculin skin test-positive (TSTpositive) patients accepted preventative treatment. Concerning the IFN-γ response to PstS-1(285-374):CFP10 in the 22-h and 5-day assays, a slight increase in contact-TSTpositivedetection was observed (23/54 and 26/54) compared to the level seen with the RD1 protein (18/54 and 24/54) whereas in the TSTnegativegroup, similarly lower numbers (≤5/48) of responders were achieved for both antigens, except for RD1 in the 5-day assay (8/48). By combining the IFN-γ responders to both antigens in the 5-day assays, slightly higher increases in positivity were found in the TSTpositive(32/54) and TSTnegative(10/48) groups. Two of 12 untreated TSTpositivecontacts progressed to active TB and were concordantly positive in all assays, except for one contact who lacked positivity in the RD1 5-day assay. We demonstrated for the first time that PstS-1(285-374):CFP10 slightly increased contact positivity and detection of active disease progression, suggesting its potential application as a TB infection marker.

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