Infections in pregnancy can result in significant complications for both the mother and fetus and can increase the risk of preterm labor. Fever in a pregnant woman also raises concern for its associated risk of preterm birth due to the release of prostaglandins and cytokines that stimulate uterine contractility. Infection can be passed to the neonate hematogenously or ascend from the genital tract. Treatment during pregnancy creates problems, as many antimicrobials cross the placenta and may have a teratogenic risk. Prophylaxis, vaccination, a high degree of suspicion, and early intervention can help improve morbidity and mortality. The pregnant patient should be asked important questions that include history of uterine tenderness and leakage of vaginal fluid, exposure to or symptoms of sexually transmitted infection, previous preterm labor, history of pregnancy complications, and a thorough social history.