On-line enantiomeric analysis using high-performance liquid chromatography in chiral separation by simulated moving bed

2008 ◽  
Vol 1189 (1-2) ◽  
pp. 292-301 ◽  
Author(s):  
João M.M. Araújo ◽  
Rui.C.R. Rodrigues ◽  
Mário F.J. Eusébio ◽  
José P.B. Mota
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Chiral Separation ◽  
High Performance ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Enantiomeric Analysis ◽  
On Line

scholarly journals Progress in the Enantioseparation of β-Blockers by Chromatographic Methods

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 468
Author(s):  
Yiwen Yang ◽  
Yehui Wang ◽  
Zongbi Bao ◽  
Qiwei Yang ◽  
Zhiguo Zhang ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
High Performance ◽  
Simulated Moving Bed ◽  
Moving Bed ◽  
Chromatographic Methods ◽  
Simulated Moving Bed Chromatography ◽  
Β Blockers

β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).

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