Simultaneous determination of optical and chemical purities of a drug with two chiral centers by liquid chromatography-circular dichroism detection on a non-chiral stationary phase

2008 ◽  
Vol 1206 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Marie Lecoeur-Lorin ◽  
Raphaël Delépée ◽  
Michèle Adamczyk ◽  
Philippe Morin
Keyword(s):  
Liquid Chromatography ◽  
Circular Dichroism ◽  
Stationary Phase ◽  
Simultaneous Determination ◽  
Chiral Stationary Phase ◽  
Chiral Centers ◽  
Circular Dichroïsm

Semimicro Determination of Sugar Configuration by Measurement of Circular Dichroism of Alditol Acetates

1973 ◽  
Vol 51 (2) ◽  
pp. 324-326 ◽  
Author(s):  
G. M. Bebault ◽  
J. M. Berry ◽  
Y. M. Choy ◽  
G. G. S. Dutton ◽  
N. Funnell ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Circular Dichroism ◽  
Structural Information ◽  
Acetoxy Group ◽  
Gas Liquid Chromatography ◽  
Circular Dichroïsm ◽  
Alditol Acetates

The configuration (D or L) of a sugar may be determined conveniently by circular dichroism measurements at 213 nm on alditol acetates, or their methylated derivatives, where the acetoxy group acts as a chromophore. Only milligram quantities of material are required and the method is well suited to analyzing fractions obtained by gas–liquid chromatography. Structural information which may be derived from the c.d. spectra is briefly discussed.

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