Electrochemical sensor for the detection of eosinophil cationic protein as a marker of allergic rhinitis based on colloidal quantum dots

2021 ◽  
Author(s):  
Yanbing Tao ◽  
Jing Huang ◽  
Yunong Zhao ◽  
Yan Chen ◽  
Qing Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Allergic Rhinitis ◽  
Electrochemical Sensor ◽  
Eosinophil Cationic Protein ◽  
Colloidal Quantum Dots ◽  
Cationic Protein

scholarly journals Traditional Chinese MedicineZHENGIdentification Provides a Novel Stratification Approach in Patients with Allergic Rhinitis

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kai-Li Liang ◽  
Rong-San Jiang ◽  
Chia-Lin Lee ◽  
Pei-Jung Chiang ◽  
Jui-Shan Lin ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Linear Regression Analysis ◽  
Eosinophil Cationic Protein ◽  
Multiple Linear Regression Analysis ◽  
Total Serum ◽  
Blood Eosinophil ◽  
Cationic Protein ◽  
Explanatory Factors ◽  
Severity Scores

Background. We aimed to apply theZHENGidentification to provide an easy and useful tool to stratify the patients with allergic rhinitis (AR) through exploring the correlation between the quantified scores of AR symptoms and the TCMZHENGs.Methods. A total of 114 AR patients were enrolled in this observational study. All participants received the examinations of anterior rhinoscopy and acoustic rhinometry. Their blood samples were collected for measurement of total serum immunoglobulin E (IgE), blood eosinophil count (Eos), and serum eosinophil cationic protein (ECP). They also received two questionnaire to assess the severity scores of AR symptoms and quantified TCMZHENGscores. Multiple linear regression analysis was used to determine explanatory factors for the score of AR manifestations.Results. IgE and ECP level, duration of AR, the 2 derived TCMZHENGscores of “Yin-Xu − Yang-Xu”, and “Qi-Xu+Blood-Xu” were 5 explanatory variables to predict the severity scores of AR symptoms. The patients who had higher scores of “Yin-Xu − Yang-Xu” or “Qi-Xu+Blood-Xu” tended to manifest as “sneezer and runner” or “blockers,” respectively.Conclusions.The TCMZHENGscores correlated with the severity scores of AR symptoms and provided an easy and useful tool to stratify the AR patients.

The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis

1997 ◽  
Vol 22 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Y. OHASHI ◽  
Y. NAKAI ◽  
Y. KAKINOKI ◽  
Y. OHNO ◽  
H. OKAMOTO ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Serum Levels ◽  
Cationic Protein

scholarly journals Differentiating the endotypes in allergic rhinitis

2021 ◽  
Vol 36 (2) ◽  
pp. 92-97
Author(s):  
A. V. Klimov ◽  
Z. V. Salahutdinova ◽  
N. A. Pronina ◽  
G. A. Kuznetsov
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Skin Tests ◽  
Research Trend ◽  
General Group ◽  
Cationic Protein ◽  
Total Ige ◽  
Interleukin 5 ◽  
Local Allergic Rhinitis ◽  
History Of

Aim. The aim of the study was to differentiate the endotypes in allergic rhinitis by key allergy markers in a mixed group of patients.Material and Methods. The study comprised a total of 48 patients, men and women, aged 18-60 years suffering from three endotypes of allergic rhinitis including the classic, local, and dual allergic rhinitis. The standard diagnostics of allergic rhinitis included taking a history of allergies, family history of allergic disease, video rhinoscopy, serum total IgE level assessment, allergy skin tests to house dust mite and pollen allergens, and study of eosinophilic inflammation parameters (eosinophil cationic protein, interleukin-5 (IL5), and eosinophil counts in blood and nasal secretion).Results. Based on total IgE level, the general group of patients was divided to two subgroups: subgroup 1 comprised patients with high IgE level (n = 22); subgroup 2 comprised patients with low IgE level (n = 26). Most of patients in these groups had contradictory results of allergy skin tests i.e. positive allergy skin test results in case of high IgE level (group 1) and vice versa. Cluster analysis-based exminations of general group allowed to categorize three subgroups of patients: patients with classic allergic rhinitis (n = 22), local allergic rhinitis (n = 22), and dual allergic rhinitis (n = 4). Besides, an increased rate of anxiety disorder was found in patients with local allergic rhinitis (p < 0.001).Conclusion. The obtained data showed promise for a new research trend in studying allergic rhinitis endotypes, namely: investigation of neuroimmune relationships in allergic tolerance disruption in the presence of this pathology.

scholarly journals Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Kawa Amin ◽  
Sulaf Mosa Issa ◽  
Kosar Mohammad Ali ◽  
Muaid Ismiel Aziz ◽  
Huner Mohamed Hama Amieen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Treatment Strategies ◽  
Serum Levels ◽  
Elisa Test ◽  
Control Group ◽  
Healthy Controls ◽  
Cationic Protein ◽  
Significant Difference ◽  
Symptom Scores

Abstract Background The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients. Subjects and methods Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test. Results There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient. Conclusions Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.

Eosinophil Cationic Protein in the Nasal Secretions of Patients With Mite Allergic Rhinitis

1993 ◽  
Vol 103 (3) ◽  
pp. 189???192 ◽  
Author(s):  
Keiko Nishioka ◽  
Chisato Saito ◽  
Toshiaki Nagano ◽  
Mitsuhiro Okano ◽  
Yu Masuda ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Nasal Secretions
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