Establishing a Canadian-Based Universal Unique Identifier for Congenital and Pediatric Cardiology Research

2021 ◽  
Author(s):  
Louis-Olivier Roy ◽  
Coby Rangsitratkul ◽  
Frédéric Dallaire
Keyword(s):  
Pediatric Cardiology ◽  
Unique Identifier

Dimerization of the Antimicrobial Peptide Polyphemusin I into One Polypeptide Chain: Theoretical and Practical Consequences

2019 ◽  
Vol 35 (5) ◽  
pp. 36-41
Author(s):  
V.A. Zenin ◽  
E.G. Sadykhov ◽  
A.N. Fedorov
Keyword(s):  
Antimicrobial Peptides ◽  
Pore Formation ◽  
Lipid Membrane ◽  
Polypeptide Chain ◽  
Unique Identifier ◽  
Bacterial Cultures ◽  
In Series ◽  
The Russian Federation ◽  
Peptide Dimerization ◽  
Putative Mechanism

A strategy of sequential dimerization of monomers of antimicrobial peptides (AMPs) into one polypeptide chain has been implemented on the example of a beta-structural AMP polyphemusin I which is one of the most effective candidate for use as an antibiotic. The possible polyphemusin I monomer and dimer structures in lipid membrane were studied in this work via molecular modeling. To this end, these molecules were chemically synthesized so that the dimer represented two monomers connected in series into one polypeptide chain with a flexible linker. The antimicrobial effects of monomer and dimer were then tested on various bacterial cultures, and their similarity was shown. Therefore, we can conclude that the pore formation is not a putative mechanism of the polyphemusin I action. antimicrobial peptides, peptide dimerization, mechanism of antimicrobial action, polyphemusin The work was supported by the Ministry of Science and Higher Education of the Russian Federation (Project Unique Identifier RFMEFI57517X0151).

Toxic Effect of 2-ethyl (bicyclo[2.2.1] heptane) on Bacterial Cells

2019 ◽  
Vol 35 (6) ◽  
pp. 67-72 ◽  
Author(s):  
I.V. Manukhov ◽  
L.S. Yaguzhinsky ◽  
M.V. Bermeshev ◽  
M.A. Zisman ◽  
V.G. Pevgov ◽  
...  
Keyword(s):  
Toxic Effect ◽  
Atmospheric Oxygen ◽  
Inducible Promoter ◽  
Oxygen Species ◽  
Bacterial Cells ◽  
Unique Identifier ◽  
E Coli ◽  
Lux Biosensors ◽  
High Level ◽  
Ministry Of Higher Education

Toxic effect of 2-ethylnorbornane (2-ethyl(bicyclo[2.2.1]heptane) (EBH)) on bacteria has been studied using the E. coli pRecA-lux and E. coli pKatG- lux cells as lux-biosensors. It was shown that the addition of EBH to the incubation medium leads to death and growth retardation, high level oxidative stress and DNA damage in E. coli cells. It is assumed that the oxidation of EBH with atmospheric oxygen causes the formation of reactive oxygen species in the medium, which makes a major contribution to the toxicity of this substance. biosensor, luciferase, bioluminescence, inducible promoter, PrecA, PkatG The authors are grateful to Stanislav Filippovich Chalkin for the development of interdisciplinary ties in the scientific community. The work was financially supported by the Ministry of Higher Education and Science of Russia (Project Unique Identifier RFMEFI60417X0181, Agreement No. 14.604.21.0181 of 26.09.2017).

Using Advanced Pulmonary Hypertension Therapies in Children

2011 ◽  
Vol 10 (2) ◽  
pp. 117-124
Author(s):  
Erika Rosenzweig ◽  
Dunbar Ivy ◽  
Maurice Beghetti ◽  
Jeffrey Feinstein
Keyword(s):  
Pulmonary Hypertension ◽  
Guest Editor ◽  
Pediatric Cardiology ◽  
Associate Professor ◽  
University Hospital ◽  
Stanford University ◽  
New Therapies ◽  
University Of Toronto ◽  
University Of Colorado ◽  
School Of Medicine

On July 8, 2011, Editor-in-Chief Erika Rosenzweig convened a discussion among a group of physicians who work daily with pediatric PH patients to share their thoughts and experiences related to using new therapies with children. Contributing to the conversation were guest editor Dunbar Ivy, MD, Professor of Pediatrics, University of Colorado; Jeffrey A. Feinstein, MD, MPH, Associate Professor, Stanford University School of Medicine; Tilman Humpl, MD, PhD, Associate Professor, Pediatrics, University of Toronto; and Professor Maurice Beghetti, Head of Pediatric Subspecialties Division and Head of Pediatric Cardiology Unit, Children's University Hospital, Geneva, Switzerland.

Agricultural Application of Web of Things Architecture

Impact ◽  
2019 ◽  
Vol 2019 (10) ◽  
pp. 61-63 ◽  
Author(s):  
Akihiro Fujii
Keyword(s):  
Internet Of Things ◽  
Agricultural Sector ◽  
Electronic Device ◽  
Specific Work ◽  
Science And Engineering ◽  
Unique Identifier ◽  
Agricultural Application ◽  
Iot Devices ◽  
The Internet Of Things ◽  
Type Pressure

The Internet of Things (IoT) is a term that describes a system of computing devices, digital machines, objects, animals or people that are interrelated. Each of the interrelated 'things' are given a unique identifier and the ability to transfer data over a network that does not require human-to-human or human-to-computer interaction. Examples of IoT in practice include a human with a heart monitor implant, an animal with a biochip transponder (an electronic device inserted under the skin that gives the animal a unique identification number) and a car that has built-in sensors which can alert the driver about any problems, such as when the type pressure is low. The concept of a network of devices was established as early as 1982, although the term 'Internet of Things' was almost certainly first coined by Kevin Ashton in 1999. Since then, IoT devices have become ubiquitous, certainly in some parts of the world. Although there have been significant developments in the technology associated with IoT, the concept is far from being fully realised. Indeed, the potential for the reach of IoT extends to areas which some would find surprising. Researchers at the Faculty of Science and Engineering, Hosei University in Japan, are exploring using IoT in the agricultural sector, with some specific work on the production of melons. For the advancement of IoT in agriculture, difficult and important issues are implementation of subtle activities into computers procedure. The researchers challenges are going on.

Pediatric Cardiology

2020 ◽  
Vol 67 (5) ◽  
pp. i
Author(s):  
Pei-Ni Jone ◽  
D. Dunbar Ivy ◽  
Stephen R. Daniels
Keyword(s):  
Pediatric Cardiology

scholarly journals Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry

2021 ◽  
Author(s):  
Yoichi Imori ◽  
Ken Kato ◽  
Victoria L. Cammann ◽  
Konrad A. Szawan ◽  
Manfred Wischnewsky ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Clinical Characteristics ◽  
Ethnic Disparities ◽  
Japanese Patients ◽  
Learning Approach ◽  
Takotsubo Syndrome ◽  
Unique Identifier ◽  
Hospital Outcomes ◽  
Machine Learning Approach ◽  
The Impact

Abstract Background Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers. Trial Registration URL: https://www.clinicaltrials.gov; Unique Identifier: NCT01947621.

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