Modified layered double hydroxides in polycaprolactone as a tunable delivery system: in vitro release of antimicrobial benzoate derivatives

Vascular and traumatic injuries of the central nervous system are recognized as global health priorities. A polypharmacology approach that is able to simultaneously target several injury factors by the combination of agents having synergistic effects appears to be promising. Herein, we designed a polymeric delivery system loaded with two drugs, ibuprofen (Ibu) and thyroid hormone triiodothyronine (T3) to in vitro release the suitable amount of the anti-inflammation and the remyelination drug. As a production method, electrospinning technology was used. First, Ibu-loaded micro (diameter circa 0.95–1.20 µm) and nano (diameter circa 0.70 µm) fibers were produced using poly(l-lactide) PLLA and PLGA with different lactide/glycolide ratios (50:50, 75:25, and 85:15) to select the most suitable polymer and fiber diameter. Based on the in vitro release results and in-house knowledge, PLLA nanofibers (mean diameter = 580 ± 120 nm) loaded with both Ibu and T3 were then successfully produced by a co-axial electrospinning technique. The in vitro release studies demonstrated that the final Ibu/T3 PLLA system extended the release of both drugs for 14 days, providing the target sustained release. Finally, studies in cell cultures (RAW macrophages and neural stem cell-derived oligodendrocyte precursor cells—OPCs) demonstrated the anti-inflammatory and promyelinating efficacy of the dual drug-loaded delivery platform.

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Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

Journal of Biomaterials Applications ◽

10.1177/0885328209344003 ◽

2009 ◽

Vol 25 (2) ◽

pp. 161-177 ◽

Cited By ~ 48

Author(s):

Bhavesh D. Kevadiya ◽

Ghanshyam V. Joshi ◽

Hasmukh A. Patel ◽

Pravin G. Ingole ◽

Haresh M. Mody ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Vitamin B6 ◽

In Vitro Release ◽

Vitamin B1 ◽

Vitro Release

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Zein-pectin composite nanoparticles as an efficient hyperoside delivery system: Fabrication, characterization, and in vitro release property

LWT ◽

10.1016/j.lwt.2020.109869 ◽

2020 ◽

Vol 133 ◽

pp. 109869

Author(s):

Xiaojing Wang ◽

Fei Peng ◽

Fuguo Liu ◽

Yaqing Xiao ◽

Feng Li ◽

...

Keyword(s):

Delivery System ◽

In Vitro Release ◽

Composite Nanoparticles ◽

Release Property ◽

Vitro Release

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Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

ISRN Pharmaceutics ◽

10.1155/2013/983053 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Elham Khodaverdi ◽

Fatemeh Kheirandish ◽

Farnaz Sadat Mirzazadeh Tekie ◽

Bibi Zahra Khashyarmanesh ◽

Farzin Hadizadeh ◽

...

Keyword(s):

Phase Transition ◽

Transition Temperature ◽

Phase Transition Temperature ◽

Delivery System ◽

In Vitro Release ◽

In Situ Forming ◽

Release Study ◽

Vitro Release

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.

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