Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

Vascular and traumatic injuries of the central nervous system are recognized as global health priorities. A polypharmacology approach that is able to simultaneously target several injury factors by the combination of agents having synergistic effects appears to be promising. Herein, we designed a polymeric delivery system loaded with two drugs, ibuprofen (Ibu) and thyroid hormone triiodothyronine (T3) to in vitro release the suitable amount of the anti-inflammation and the remyelination drug. As a production method, electrospinning technology was used. First, Ibu-loaded micro (diameter circa 0.95–1.20 µm) and nano (diameter circa 0.70 µm) fibers were produced using poly(l-lactide) PLLA and PLGA with different lactide/glycolide ratios (50:50, 75:25, and 85:15) to select the most suitable polymer and fiber diameter. Based on the in vitro release results and in-house knowledge, PLLA nanofibers (mean diameter = 580 ± 120 nm) loaded with both Ibu and T3 were then successfully produced by a co-axial electrospinning technique. The in vitro release studies demonstrated that the final Ibu/T3 PLLA system extended the release of both drugs for 14 days, providing the target sustained release. Finally, studies in cell cultures (RAW macrophages and neural stem cell-derived oligodendrocyte precursor cells—OPCs) demonstrated the anti-inflammatory and promyelinating efficacy of the dual drug-loaded delivery platform.

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High Internal Phase Emulsions Synergistically Stabilized by Sodium Carboxymethyl Cellulose and Palm Kernel Oil Ethoxylates as an Essential Oil Delivery System

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.0c07606 ◽

2021 ◽

Author(s):

Qian Chen ◽

Xiumei Tai ◽

Jiyun Li ◽

Chunhui Li ◽

Lingxiao Guo

Keyword(s):

Essential Oil ◽

Delivery System ◽

Carboxymethyl Cellulose ◽

Palm Kernel ◽

Sodium Carboxymethyl Cellulose ◽

Palm Kernel Oil ◽

Kernel Oil ◽

Internal Phase

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Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

Journal of Biomaterials Applications ◽

10.1177/0885328209344003 ◽

2009 ◽

Vol 25 (2) ◽

pp. 161-177 ◽

Cited By ~ 48

Author(s):

Bhavesh D. Kevadiya ◽

Ghanshyam V. Joshi ◽

Hasmukh A. Patel ◽

Pravin G. Ingole ◽

Haresh M. Mody ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Vitamin B6 ◽

In Vitro Release ◽

Vitamin B1 ◽

Vitro Release

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Zein-pectin composite nanoparticles as an efficient hyperoside delivery system: Fabrication, characterization, and in vitro release property

LWT ◽

10.1016/j.lwt.2020.109869 ◽

2020 ◽

Vol 133 ◽

pp. 109869

Author(s):

Xiaojing Wang ◽

Fei Peng ◽

Fuguo Liu ◽

Yaqing Xiao ◽

Feng Li ◽

...

Keyword(s):

Delivery System ◽

In Vitro Release ◽

Composite Nanoparticles ◽

Release Property ◽

Vitro Release

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Preparation of a Sustained Release Drug Delivery System for Dexamethasone by a Thermosensitive, In Situ Forming Hydrogel for Use in Differentiation of Dental Pulp

ISRN Pharmaceutics ◽

10.1155/2013/983053 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Elham Khodaverdi ◽

Fatemeh Kheirandish ◽

Farnaz Sadat Mirzazadeh Tekie ◽

Bibi Zahra Khashyarmanesh ◽

Farzin Hadizadeh ◽

...

Keyword(s):

Phase Transition ◽

Transition Temperature ◽

Phase Transition Temperature ◽

Delivery System ◽

In Vitro Release ◽

In Situ Forming ◽

Release Study ◽

Vitro Release

In situ forming delivery systems composed of block copolymers are attracting substantial attention due to their ease of use, biocompatibility, and biodegradability. In this study, the thermoresponsive triblock copolymer PLGA-PEG-PLGA was studied as a dexamethasone delivery system. Dexamethasone, a synthetic glucocorticoid, is used clinically to improve inflammation, pain, and the hyperemesis of chemotherapy, and it is applied experimentally as a differentiation factor in tissue engineering. PLGA-PEG-PLGA was synthesised under microwave irradiation for 5 min. The obtained copolymer was characterised to determine its structure and phase transition temperature. An in vitro release study was conducted for various copolymer structures and drug concentrations. The yield of the reaction and HNMR analysis confirmed the appropriateness of the microwave-assisted method for PLGA-PEG-PLGA synthesis. Phase transition temperature was affected by the drug molecule as well as by the copolymer concentration and structure. An in vitro release study demonstrated that release occurs mainly by diffusion and does not depend on the copolymer structure or dexamethasone concentration.

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Denatured collagen as support for a FGF-2 delivery system: physicochemical characterizations and in vitro release kinetics and bioactivity

Biomaterials ◽

10.1016/j.biomaterials.2003.10.026 ◽

2004 ◽

Vol 25 (17) ◽

pp. 3761-3772 ◽

Cited By ~ 39

Author(s):

Marie-France Côté ◽

Gaetan Laroche ◽

Edith Gagnon ◽

Pascale Chevallier ◽

Charles J Doillon

Keyword(s):

Delivery System ◽

Release Kinetics ◽

In Vitro Release ◽

Vitro Release

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THE EFFECT OF TWEEN 80, PALM KERNEL OIL, AND ITS CONVERSION PRODUCT ON IN VITRO PENETRATION ENHANCEMENT OF INDOMETHACIN THROUGH RABBIT SKIN

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i7.18608 ◽

2017 ◽

Vol 10 (7) ◽

pp. 284

Author(s):

Anayanti Arianto ◽

Rizki Amelia ◽

Hakim Bangun

Keyword(s):

Palm Kernel ◽

Tween 80 ◽

Skin Penetration ◽

Rabbit Skin ◽

Enhancing Effect ◽

Palm Kernel Oil ◽

Kernel Oil ◽

Low Concentrations ◽

Ointment Base

Objective: Objective of the study was to evaluate the effect of Tween 80, palm kernel oil (PKO), and its conversion products (hydrolyzed and transesterificated products) on the in vitro rabbit skin penetration of indomethacin from hydrocarbon ointment base.Materials and Methods: In vitro penetration of indomethacin through hairless rabbit skin from hydrocarbon ointment base (white petrolatum) was evaluated using a diffusion cell. The effects of Tween 80, PKO, and its conversion products at various concentrations were evaluated.Results: The higher of the concentration of Tween 80 until 5%, the higher of the indomethacin penetration. However, at the concentration above 5%, the penetration was decreased with the increasing concentration of Tween 80 used. The amount of indomethacin penetrated increased with the increasing of the concentration of PKO and its conversion products used. Hydrolyzed product showed the higher indomethacin penetration enhancing effect than PKO. Transesterificated product showed the highest penetration enhancing effect. However, the combination of Tween 80 with transesterificated product showed lower penetration enhancing effect compared to transesterificated product only.Conclusion: Tween 80 at low concentrations, PKO, and its conversion products could be used to enhance indomethacin penetration.

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Modified layered double hydroxides in polycaprolactone as a tunable delivery system: in vitro release of antimicrobial benzoate derivatives

Applied Clay Science ◽

10.1016/j.clay.2011.01.025 ◽

2011 ◽

Vol 52 (1-2) ◽

pp. 34-40 ◽

Cited By ~ 60

Author(s):

Valeria Bugatti ◽

Giuliana Gorrasi ◽

Francesca Montanari ◽

Morena Nocchetti ◽

Loredana Tammaro ◽

...

Keyword(s):

Delivery System ◽

Layered Double Hydroxides ◽

In Vitro Release ◽

Double Hydroxides ◽

Vitro Release ◽

Benzoate Derivatives

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In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2016.08.011 ◽

2016 ◽

Vol 105 (11) ◽

pp. 3387-3398 ◽

Cited By ~ 19

Author(s):

Emelie Ahnfelt ◽

Erik Sjögren ◽

Per Hansson ◽

Hans Lennernäs

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

In Vitro Release ◽

Release Mechanisms ◽

Vitro Release

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In vitro Evaluation of Antifungal Activity of Virgin Coconut oil and White Palm Kernel Oil on Candida Species-Experimental Study

Microbiology Research Journal International ◽

10.9734/mrji/2019/v27i230092 ◽

2019 ◽

pp. 1-9

Author(s):

Hortense Gonsu Kamga ◽

Sarah Riwom Essama ◽

Yves Le Grand Napa Tchuedji ◽

Maurice Boda ◽

Stève Henri Voundi Olugu ◽

...

Keyword(s):

Experimental Study ◽

Candida Albicans ◽

Candida Parapsilosis ◽

Palm Kernel ◽

Coconut Oil ◽

Virgin Coconut Oil ◽

Palm Kernel Oil ◽

Kernel Oil ◽

Maximum Inhibition

Aims: The aim of this study is to evaluate in vitro the antifungal activity of virgin coconut oil and the white palm kernel oil on the growth of six species of the genus Candida. Study Design: This study is an experimental study. Place and Duration of the Study: Department of Microbiology, Laboratory of Microbiology of the University of Yaoundé I. Laboratory of Bacteriology, Yaoundé University teaching Hospital between April to September 2017. Methodology: We included six species of Candida. The method of diffusion discs in agar medium was used for Sensitivity tests and macro-dilution in liquid medium was used for dilution. Results: Majority of the species tested were resistant to conventional antifungals used. Candida hoemulonii was the most sensitive species to virgin coconut oil with percentages of inhibitions higher than 50 % when the concentration of oil was only 3.125 mg/mL and a maximum inhibition percentage of 90.10 % when the concentration of oil was 100 mg/mL. Candida albicans, was the least susceptible species to virgin coconut oil with a maximum inhibition percentage of 59.85 % when the concentration of oil was 100 mg/mL. Candida lipolytica was the most sensitive specie to white palm kernel oil with a maximum inhibition percentage of 90,26 % when the concentration of oil was 100 mg/mL and Candida parapsilosis was the least susceptible species to white palm kernel oil with a maximum inhibition percentage of 52,69 % at the same concentration. In addition, the white palm kernel oil which was more active (P˂0.05) than virgin coconut oil was introduced in the Sabouraud broth and the MIC and MFC obtained with Fluconazole was lower on Candida albicans and Candida parapsilosis compared to activity of Fluconazole without palm kernel oil in the medium. Nystatin showed also lower MIC and MFC values on Candida parapsilosis when palm kernel oil was present in the culture medium. Conclusion: These results prove that these oils can be used to develop antifungals drugs.

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