Modification to systemic anticancer therapy at the start of the COVID-19 pandemic and its overall impact on survival outcomes in patients with colorectal cancer

AbstractDNA damage-inducible transcript 4 (DDIT4) is induced in various cellular stress conditions. This study was conducted to investigate expression and prognostic significance of DDIT4 protein as a biomarker in the patients with colorectal cancer (CRC). PPI network and KEGG pathway analysis were applied to identify hub genes among obtained differentially expressed genes in CRC tissues from three GEO Series. In clinical, expression of DDIT4 as one of hub genes in three subcellular locations was evaluated in 198 CRC tissues using immunohistochemistry method on tissue microarrays. The association between DDIT4 expression and clinicopathological features as well as survival outcomes were analyzed. Results of bioinformatics analysis indicated 14 hub genes enriched in significant pathways according to KEGG pathways analysis among which DDIT4 was selected to evaluate CRC tissues. Overexpression of nuclear DDIT4 protein was found in CRC tissues compared to adjacent normal tissues (P = 0.003). Furthermore, higher nuclear expression of DDIT4 was found to be significantly associated with the reduced tumor differentiation and advanced TNM stages (all, P = 0.009). No significant association was observed between survival outcomes and nuclear expression of DDIT4 in CRC cases. Our findings indicated higher nuclear expression of DDIT4 was significantly associated with more aggressive tumor behavior and more advanced stage of disease in the patients with CRC.

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Abstract 111: Colorectal Cancer Presentation and Survival Outcomes in Nigeria: A Prospective Multi-Centre Cohort Study of 543 Patients

10.1158/1538-7755.asgcr21-111 ◽

2021 ◽

Author(s):

Adeniyi Aderibigbe ◽

Anna Dare ◽

Gregory Knapp ◽

Olusegan Alatise ◽

T. Peter Kingham

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

Survival Outcomes

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Human Cytomegalovirus Induced Immune Regulation Is Correlated With Poor Prognosis in Colorectal Cancer Patients

10.21203/rs.3.rs-860887/v1 ◽

2021 ◽

Author(s):

Yangyang Fang ◽

Qiongdan Wang ◽

Kaizhao Huang ◽

Mengyue Zhang ◽

Shunjie Pei ◽

...

Keyword(s):

Colorectal Cancer ◽

Immune Function ◽

Human Cytomegalovirus ◽

Poor Prognosis ◽

Hcmv Infection ◽

Information Matrix ◽

Clinical Information ◽

Gene Expression Omnibus ◽

Survival Outcomes ◽

Survival Prognosis

Abstract Available evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progression of colorectal cancer (CRC). However, the correlation between HCMV infection and survival outcomes in CRC patients is unclear. Here, we constructed a flow algorithm to identify HCMV sequences based on the RNA-seq data of CRC patients derived from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The patients' clinical information matrix was used to calculate Euclidean distance to filter out suitable patients not infected with HCMV, combining with the patient's survival outcome to reveal how HCMV infection is involved in CRC progression.HCMV infection is widespread in CRC patients., The prevalence of HCMV infection is ranging from 10% to 36% in 4 independent CRC datasets with infection being concentrated in carcinoma tissue rather than in normal tissue. In addition, HCMV positive patients had a poor survival prognosis, with three of the HCMV genes associated with poor patient survival outcomes, UL82, UL42 and UL117. Most importantly, we suppose that the regulation of immune function by HCMV may be the key to the poor prognosis of CRC patients. We found that HCMV infection was associated with poor prognosis in CRC patients and identified three prognosis associated HCMV genes. The regulation of immune function caused by HCMV infection was the key factor while HCMV positive CRC patients mostly presented a state of immunosuppression. This may provide new ideas for personalized treatment of CRC patients, especially in immunotherapy.

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Prior malignancy impact on survival outcomes of glioblastoma multiforme; population-based study

International Journal of Neuroscience ◽

10.1080/00207454.2018.1538989 ◽

2018 ◽

Vol 129 (5) ◽

pp. 447-454 ◽

Cited By ~ 1

Author(s):

Muneer J. Al-Husseini ◽

Anas M. Saad ◽

Kholoud M. El-Shewy ◽

Ninos E. Nissan ◽

Mohamed M. Gad ◽

...

Keyword(s):

Glioblastoma Multiforme ◽

Population Based ◽

Survival Outcomes ◽

Population Based Study ◽

Impact On Survival ◽

Prior Malignancy

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Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies

JNCI Cancer Spectrum ◽

10.1093/jncics/pkab077 ◽

2021 ◽

Author(s):

Elizabeth Alwers ◽

Prudence R Carr ◽

Barbara Banbury ◽

Viola Walter ◽

Jenny Chang-Claude ◽

...

Keyword(s):

Colorectal Cancer ◽

Dose Response ◽

Smoking Behavior ◽

Stage I ◽

Current Evidence ◽

Survival Outcomes ◽

Heavy Smoking ◽

Incidence And Mortality ◽

Clear Dose Response ◽

Former Smokers

Abstract Background Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies, but current evidence on smoking in association with survival after CRC diagnosis is limited. Methods We pooled data from 12,345 patients with stage I-IV CRC from 11 epidemiologic studies in the International Survival Analysis in Colorectal Cancer Consortium (ISACC). Cox proportional hazards regression models were used to evaluate the associations of pre-diagnostic smoking behavior with overall, CRC-specific and non-CRC-specific survival. Results Among 12,345 patients with CRC, 4379 (35.5%) died (2515 from CRC), over a median follow-up time of 7.5 years. Smoking was strongly associated with worse survival in stage I-III patients, whereas no association was observed among stage IV patients. Among stage I-III patients, clear dose-response relationships with all survival outcomes were seen for current smokers. For example, current smokers with ≥40 pack-years had statistically significantly worse overall, CRC-specific, and non-CRC-specific survival compared to never smokers (hazard ratio [HR] =1.94, 95% confidence interval [CI] =1.68–2.25; HR = 1.41, 95% CI = 1.12–1.78; and HR = 2.67, 95% CI = 2.19–3.26, respectively). Similar associations with all survival outcomes were observed for former smokers who had quit for less than 10 years, but only a weak association with non-CRC-specific survival was seen among former smokers who had quit for more than 10 years. Conclusions This large consortium of CRC patient studies provides compelling evidence that smoking is strongly associated with worse survival of stage I-III CRC patients in a clear dose-response manner. The detrimental effect of smoking was primarily related to non-colorectal cancer events, but current heavy smoking also showed an association with CRC-specific survival.

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