Redox ingredients for oxidative stress prevention: the unexplored potentiality of coffee

2009 ◽  
Vol 27 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Mauro Serafini ◽  
Maria Francesca Testa
Keyword(s):  
Oxidative Stress ◽  
Stress Prevention

scholarly journals Light and CO2 Modulate the Accumulation and Localization of Phenolic Compounds in Barley Leaves

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 385
Author(s):  
Lena Hunt ◽  
Karel Klem ◽  
Zuzana Lhotáková ◽  
Stanislav Vosolsobě ◽  
Michal Oravec ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phenolic Compounds ◽  
Co2 Concentration ◽  
Environmental Stressors ◽  
Low Light ◽  
Mesophyll Cells ◽  
Stress Prevention ◽  
Tolerant Variety ◽  
Barley Leaves

Barley (Hordeum vulgare) accumulates phenolic compounds (PhCs), which play a key role in plant defense against environmental stressors as antioxidants or UV screening compounds. The influence of light and atmospheric CO2 concentration ([CO2]) on the accumulation and localization of PhCs in barley leaves was examined for two varieties with different tolerances to oxidative stress. PhC localization was visualized in vivo using fluorescence microscopy. Close relationships were found between fluorescence-determined localization of PhCs in barley leaves and PhC content estimated using liquid chromatography coupled with mass spectroscopy detection. Light intensity had the strongest effect on the accumulation of PhCs, but the total PhC content was similar at elevated [CO2], minimizing the differences between high and low light. PhCs localized preferentially near the surfaces of leaves, but under low light, an increasing allocation of PhCs in deeper mesophyll layers was observed. The PhC profile was significantly different between barley varieties. The relatively tolerant variety accumulated significantly more hydroxycinnamic acids, indicating that these PhCs may play a more prominent role in oxidative stress prevention. Our research presents novel evidence that [CO2] modulates the accumulation of PhCs in barley leaves. Mesophyll cells, rather than epidermal cells, were most responsive to environmental stimuli in terms of PhC accumulation.

Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo

2011 ◽  
Vol 415 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Cédric Chaveroux ◽  
Sarah Lambert-Langlais ◽  
Laurent Parry ◽  
Valérie Carraro ◽  
Céline Jousse ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Prevention

scholarly journals Selenium and alpha-tocopherol reduces ϑluoride induced oxidative stress in brain and muscle of mice

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1794-1799
Author(s):  
Chandra Shakar Reddy N ◽  
Pratap Reddy K
Keyword(s):  
Oxidative Stress ◽  
Environmental Pollutants ◽  
Treated Group ◽  
Alpha Tocopherol ◽  
Control Group ◽  
Protective Effects ◽  
Stress Prevention ◽  
Wide Availability ◽  
Markers Of Oxidative Stress ◽  
Ros Formation

Fluoride is one of the common environmental pollutants. Its excessive exposure results in a wide array of toxicity phenotypes including oxidative stress, skeletal and soft tissue damage etc. Antioxidants such as Selenium (Se) and α-tocopherol are attractive agents for oxidative stress prevention because of their safety profile and wide availability. It is known that in combination, Se and alpha-tocopherol act synergistically against ROS formation. This study investigated the protective effects of selenium (05 µg/kg BW) and Alpha-tocopherol (2 mg/kg BW) on markers of oxidative stress in brain and muscle of mice exposed to sodium fluoride (20mg/kg BW) for 15 days. The results showed significant (p<0.05) alterations in markers of oxidative stress includes; an increase in xanthine oxidase activity and lipid peroxidation, a decline in SOD, CAT, GST and GPx activities in fluoride exposure group in comparison with control group indicates oxidative stress induced by fluoride. These changes were reversed modestly in Se and alpha-tocopherol alone treated groups and significantly  (p<0.05) in the combinedly treated group indicating synergistic action in mitigation of fluoride effect.

Oxidative stress prevention and anti-apoptosis activity of grape ( Vitis vinifera L.) stems in human keratinocytes

2016 ◽  
Vol 87 ◽  
pp. 92-102 ◽  
Author(s):  
Raúl Domínguez-Perles ◽  
Ana Guedes ◽  
Marcelo Queiroz ◽  
Amélia M. Silva ◽  
Ana I.R.N.A. Barros
Keyword(s):  
Oxidative Stress ◽  
Vitis Vinifera ◽  
Human Keratinocytes ◽  
Vitis Vinifera L ◽  
Stress Prevention

scholarly journals Olprinone protects the liver from ischemia–reperfusion injury through oxidative stress prevention and protein kinase Akt activation

2018 ◽  
Vol 96 (3) ◽  
pp. 227-231 ◽  
Author(s):  
Mohamed Bejaoui ◽  
Mohamed Amine Zaouali ◽  
Rim Sakly ◽  
Hassen Ben Abdennebi
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mitochondrial Damage ◽  
Liver Graft ◽  
Protective Effects ◽  
Akt Activation ◽  
Stress Prevention ◽  
Protein Kinase Akt

Liver ischemia–reperfusion (IR) injury is inevitable in surgical procedures such as hepatic resection and liver transplantation. It represents a leading cause of liver graft dysfunction and primary nonfunction after transplantation. Phosphodiesterase (PDE) inhibitors are emerging as effective drugs able to reduce IR damage. The aim of this study was to investigate the effect of selective PDE-3 inhibitor olprinone (Olp) against liver IR injury. Male Wistar rats were subjected to 1 h of partial warm ischemia (70%) followed by 6 h of reperfusion. Before ischemia, rats were treated with saline (IR group), Olp (Olp group), or Olp with Akt inhibitor LY294002 (Olp plus LY group). After reperfusion, hepatic injury (transaminase activities), mitochondrial damage (glutamate dehydrogenase activity), oxidative stress (malondialdehyde and glutathione concentrations and catalase and superoxide dismutase activities), and protein kinase Akt activation were evaluated. Rat treatment with Olp reduced liver injury, prevented mitochondrial damage, decreased lipid peroxidation, and enhanced antioxidant enzymes. Also, Olp induced a significant activation in protein kinase Akt. Inhibition of Akt with LY294002 abolished all of the protective effects of Olp. In conclusion, Olp treatment may be an effective strategy in reducing liver IR injury through oxidative stress prevention and Akt activation.

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