Gear up for therapeutic application of non-invasive brain stimulation in Parkinson’s disease

Author(s):  
Masako Kinoshita ◽  
Antonio Suppa
2018 ◽  
Vol 129 (4) ◽  
pp. e9
Author(s):  
L. Brabenec ◽  
J. Mekyska ◽  
Z. Galáž ◽  
P. Klobušiakova ◽  
M. Koštálová ◽  
...  

2019 ◽  
Vol 30 (8) ◽  
pp. 821-837 ◽  
Author(s):  
Sharon Israely ◽  
Gerry Leisman

Abstract Individuals post-stroke sustain motor deficits years after the stroke. Despite recent advancements in the applications of non-invasive brain stimulation techniques and Deep Brain Stimulation in humans, there is a lack of evidence supporting their use for rehabilitation after brain lesions. Non-invasive brain stimulation is already in use for treating motor deficits in individuals with Parkinson’s disease and post-stroke. Deep Brain Stimulation has become an established treatment for individuals with movement disorders, such as Parkinson’s disease, essential tremor, epilepsy, cerebral palsy and dystonia. It has also been utilized for the treatment of Tourette’s syndrome, Alzheimer’s disease and neuropsychiatric conditions such as obsessive-compulsive disorder, major depression and anorexia nervosa. There exists growing scientific knowledge from animal studies supporting the use of Deep Brain Stimulation to enhance motor recovery after brain damage. Nevertheless, these results are currently not applicable to humans. This review details the current literature supporting the use of these techniques to enhance motor recovery, both from human and animal studies, aiming to encourage development in this domain.


2021 ◽  
Vol 11 (1) ◽  
pp. 65
Author(s):  
Yeray González-Zamorano ◽  
Josué Fernández-Carnero ◽  
Francisco José Sánchez-Cuesta ◽  
Aida Arroyo-Ferrer ◽  
Athanasios Vourvopoulos ◽  
...  

Pain is an under-reported but prevalent symptom in Parkinson’s Disease (PD), impacting patients’ quality of life. Both pain and PD conditions cause cortical excitability reduction and non-invasive brain stimulation. Mental representation techniques are thought to be able to counteract it, also resulting effectively in chronic pain conditions. We aim to conduct two independent studies in order to evaluate the efficacy of transcranial direct current stimulation (tDCS) and mental representation protocol in the management of pain in PD patients during the ON state: (1) tDCS over the Primary Motor Cortex (M1); and (2) Action Observation (AO) and Motor Imagery (MI) training through a Brain-Computer Interface (BCI) using Virtual Reality (AO + MI-BCI). Both studies will include 32 subjects in a longitudinal prospective parallel randomized controlled trial design under different blinding conditions. The main outcomes will be score changes in King’s Parkinson’s Disease Pain Scale, Brief Pain Inventory, Temporal Summation, Conditioned Pain Modulation, and Pain Pressure Threshold. Assessment will be performed pre-intervention, post-intervention, and 15 days post-intervention, in both ON and OFF states.


2021 ◽  
Vol 14 (3) ◽  
pp. 571-578
Author(s):  
Lubos Brabenec ◽  
Patricia Klobusiakova ◽  
Patrik Simko ◽  
Milena Kostalova ◽  
Jiri Mekyska ◽  
...  

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